Gene References into Functions |
- Our studies demonstrate that a collagen-I-dense ECM can potently alter hormonal signals to drive the progression of ERalpha + breast cancer, increasing intravasation and pulmonary metastases. PMID: 28103936
- Offspring that inherited the osteogenesis imperfect (OI) and high bone mass alleles had higher bone mass and strength than mice that inherited the OI allele alone. PMID: 27297606
- a surface population of Hsp90 extracellularly binds TGFbetaRI and this complex behaves as an active participant in collagen production in TGFbeta-activated fibroblasts. PMID: 27418101
- Gremlin1 accelerates hepatic stellate cell activation through upregulation of TGF-B1, alpha-SMA, and COL1a1 expression in a liver fibrosis disease model. PMID: 28467108
- collagen-I-mediated inhibition of proplatelet formation is specifically controlled by GPVI. PMID: 27505889
- Col1a1Jrt/+ mutant mice produce craniofacial and dental defects consistent with osteogenesis imperfecta and Ehlers-Danlos syndrome PMID: 26951553
- the rate of collagen I degradation was increased in Poldip2(+/-) vs. Poldip2(+/+) MASMs. Conversely, activation of the PI3K/Akt/mTOR signaling pathway, involved in regulation of protein synthesis, was significantly elevated in Poldip2(+/-) MASMs as was beta1-integrin expression. PMID: 26801741
- These data provided a plausible mechanism linking maternal vitamin D deficiency with altered postnatal lung function. PMID: 27121020
- Col1 expression was seen in the cartilage zone of the mandibular condyle cartilage. PMID: 26362410
- the Col1a1Jrt/+ mouse model of severe OI has hypersensitivity to mechanical and thermal stimuli, consistent with a state of chronic pain PMID: 26277094
- HRG binds to alpha2 integrin through low-affinity interactions in a heparin sulfate-independent manner, thereby blocking endothelial cells adhesion to collagen I. PMID: 26051322
- Calreticulin in mediates vascular smooth muscle cell responses to injury through the regulation of collagen deposition and neointima formation. PMID: 26910059
- Homocysteine Induces Collagen I Expression by Downregulating Histone Methyltransferase G9a PMID: 26192994
- These data suggested that intestinal epithelial cells were injured after IM treatment through the pVHL overexpression-induced degradation of collagen I or HIF-1alpha. PMID: 26551465
- lipid nanoparticles loaded with small interfering RNA to the procollagen alpha1(I) gene specifically reduce total hepatic collagen content without detectable side effects, potentially qualifying as a therapy for fibrotic liver diseases PMID: 26096209
- Collagen Ialpha1 matricryptin p1158/59 facilitates left ventricle remodeling post-myocardial infarction by regulating scar formation through targeted extracellular matrix generation and stimulation of angiogenesis. PMID: 26383724
- low-level laser therapy influences the expression of col1a1 and vegf in a mouse fibroblast cell line. PMID: 25171833
- Hgh fat diet increased TGFbeta1 protein expression, Smad3 activation, and collagen deposition in skeletal muscle, and exercise attenuated TGFbeta1 protein expression and collagen deposition in skeletal muscle. PMID: 25689619
- During heart valve development, Krox20-mediated activation of fibrillar Col1a1 and Col3a1 genes is crucial to avoid postnatal degeneration of the aortic valve leaflets. PMID: 25344368
- Data indicate significantly reduced volumetric density of elastin and collagen and thinner skin dermis were observed in Marfan mice. PMID: 25086405
- Fibrocytes are not an essential source of type I collagen during lung fibrosis. PMID: 25281715
- Allele-specific Col1a1 silencing reduces mutant collagen in fibroblasts from Brtl mouse, a model for classical osteogenesis imperfecta. PMID: 24022296
- These findings reveal a novel aging cascade whereby resistance to collagen cleavage accelerates cellular aging. PMID: 23957394
- Hypoxic tumor environments exhibit disrupted collagen I fibers and low macromolecular transport. PMID: 24349142
- results indicate that Hrd1 plays an important role in the maturation of collagen I in renal fibrosis, and that Sec23A pathway is required for ER-to-Golgi procollagen trafficking to promote collagen synthesis PMID: 24114659
- Data indicate a significantly increased expression of type I collagen, TIMP-2, TGF-beta, PAI-1 and RAGE in diabetic db/db cells. PMID: 23991045
- Analysis of mutant mouse lines for Col1a1 and Jag1 (Delta-Notch pathway) that both showed clear alterations in several bone-related parameters PMID: 23371561
- the absence of integrin alpha2beta1 alleviates the effects of age related bone degradation through over-expression of collagen type I. PMID: 23680479
- Data indicate serine-threonine kinase receptor-associated protein (STRAP) as a novel regulator of the coordinated translation of collagen alpha1(I) and alpha2(I) mRNAs. PMID: 23918805
- This study deministrated that collagen1alpha1 cells as a novel source of the fibrotic scar after spinal cord injury and shift the focus from the meninges to the vasculature during scar formation. PMID: 23966707
- DNA injection and electroporation of the testes showed that spermatogonia self-renewal ability was impaired remarkably with the loss-of-function of Col1a1. PMID: 23064687
- Strong transgenerational inheritance of these perturbations was observed only at transgenes integrated at the Col1a1 locus, where both activating and repressive chromatin modifications were heritable for multiple generations. PMID: 23325759
- Trps1 is identified as a potent inhibitor of Dspp expression and the subsequent mineralization of dentin. PMID: 22508542
- Hypermethylation of CpG sites in the promoter/exon 1 of COL1A1 may underlie reduced collagen synthesis at the transcriptional level in myopic scleras. PMID: 22690110
- we show that Prdm5 controls both Collagen I transcription and fibrillogenesis by binding inside the Col1a1 gene body and maintaining RNA polymerase II occupancy PMID: 22589746
- Higher MMP2 expression in mice on high-fat diet suggests its involvement in the reduction of COL1A1 protein abundance with high-fat diet. PMID: 21775118
- LH3-mediated glucosylation occurs at the specific molecular loci in the type I collagen molecule and plays critical roles in controlling collagen cross-linking, fibrillogenesis, and mineralization. PMID: 22573318
- atomistic simulations of a section of mouse type I heterotrimer and homotrimer collagen molecules PMID: 22325288
- Adult male offspring of OVA-sensitized /challenged dams exposed to maternal cigarette smokeS (OSM) displayed 1.8-fold greater collagen 1A1 mRNA levels. PMID: 21718087
- Fetal microchimeric cells switch on collagen type I transcription implicating mesenchymal lineage cells. PMID: 21150166
- study reports that vimentin filaments associate with collagen mRNAs in a 5'stem-loop sequence and LARP6-dependent manner and stabilize collagen mRNAs PMID: 21746880
- an important role of the 5' stem-loop in regulating type I collagen mRNA and protein expression PMID: 21193410
- Periostin is a PTH regulated extracellular matrix protein, partly co-localizing with collagen 1a1. PMID: 20654714
- SPARC is a critical regulator of collagen assembly. The type I collagen N-propeptide can effect the incorporation of collagen I into fibrillar extracellular matrix. PMID: 20708079
- Col(I)-Luc transgenic mice can be applied in the field of bone tissue engineering for monitoring bone repair processes and for investigating osteoinductive molecules or scaffolds. PMID: 20218816
- Transgenic (col1A1) Col3.6-HSD2 mice showed a low bone mass phenotype, with decreased ex vivo osteogenesis, which strengthens the concept that endogenous glucocorticoid signaling is required for optimal bone mass acquisition PMID: 20541046
- Exogenous VEGF restored resistance to oxidative stress in BAV SMCs to normal. Type I collagen gene induction was increased in BAV aorta. PMID: 21095332
- Demonstrate that collagen content is important to extralobar pulmonary artery stiffening caused by chronic hypoxia in Col1a1 transgenic mice. PMID: 20852040
- Interactions of alpha1(I)(3) homotrimers and normal alpha1(I)(2)alpha2(I) heterotrimers with fibroblast collagenase (MMP-1), were studied. PMID: 20463013
- Col1a1 gene regulatory elements have sites of stress-induced DNA duplex destabilization and nuclear scaffold/matrix association potential PMID: 11813254
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