Gene References into Functions |
- This repletion study shows that loss of capacity to incorporate Se into Gpx1 in Gpx1 KO mice does not dramatically alter expression of other Se biomarkers, nor the short-term flux of Se from intestine to liver to kidney. PMID: 29502249
- interactive modulations between the GPx-1 gene and Nrf2-dependent glutathione induction are critical for attenuating phencyclidine-induced abnormal behaviors in mice. PMID: 27796745
- Notably, CUEDC2 promoted E3 ubiquitin ligases tripartite motif-containing 33 (TRIM33)-mediated the antioxidant enzyme, glutathione peroxidase 1 (GPX1) ubiquitination, and proteasome-dependent degradation. PMID: 27286733
- GPx1 does not clearly exacerbate hyperoxia-induced increases in oxidative stress or lung injury but may alter pulmonary immune function. PMID: 28385808
- GPx-1 expression deters the unfolded protein response following exposure to cigarette smoke PMID: 28070146
- Glutathione peroxidase 1 (GPx1) knockdown not only induced oxidative stress characterized by the increased production of reactive oxygen species (ROS) but also caused reductive stress indicated by an elevation of glutathione (GSH)/oxidized GSH (GSSG) ratio. PMID: 28039148
- Exposure to far infrared rays significantly protects acute restraint stress oxidative burdens via inhibition of JAK2/STAT3 signaling by induction of GPx-1. PMID: 26850477
- Genetic inhibition of Gpx1 potentiates cocaine-induced renal damage via activation of AT1R by inhibition of PI3K-Akt signaling. PMID: 26930476
- Glutathione peroxidase 1 deficiency attenuates concanavalin A-induced liver injury by induction of T-cell hyporesponsiveness through chronic reactive oxygen species exposure. PMID: 27124582
- GPx1 was found to play a critical role in regulating pro-inflammatory pathways in vascular endothelium. PMID: 26569096
- Plasmalogen enrichment via batyl alcohol supplementation attenuated atherosclerosis in ApoE- and ApoE/GPx1-deficient mice. PMID: 26545014
- Gpx1 expression in the mouse skeletal muscle can be altered by both exercise and dyslipidemia through changes in DNA methylation, leading to a fine regulation of free radical metabolism. PMID: 27010651
- our findings unveil a new metabolic role for Reg3beta in protein nitration and a new biosynthesis control of GPX1 by a completely "unrelated" regenerating protein, Reg3beta, via transcriptional activation of Scly PMID: 23811004
- Rora induces the mRNA level of antioxidant enzymes, superoxide dismutase 2 and glutathione peroxidase 1, through the Rora response elements located in the upstream promoters of Sod2 and Gpx1. PMID: 24597775
- High-fat-fed Gpx1(-/-) mice also exhibited decreased hepatic steatosis and liver damage accompanied by decreased plasma insulin and decreased glucose-induced insulin secretion. PMID: 24252128
- we propose that ileocolitis in the DKO mice is caused by Nox1, which is induced by TNF. The milder disease in female het-TKO intestine is probably due to random or imprinted X-chromosome inactivation, which produces mosaic Nox1 expression. PMID: 24374371
- PD-linked mutations in Parkin and DJ-1 cause dysregulation of neurotransmitter systems beyond the nigrostriatal dopaminergic circuit especially in the context of Gpx1 deficiency. PMID: 24075852
- During early differentiation of embryonic stem (ES) cells, the quick degradation of GPx-1 was mediated by proteasome. Both knockdown of GPx-1 expression with shRNA and inhibiting GPx-1 activity by inhibitor led to the differentiation of ES cells. PMID: 24802396
- Data indicate that he macrophage-colony-stimulating factor (MCSF) and oxLDL-induced proliferation of peritoneal macrophages from GPx-1(-/-)ApoE(-/-) mice was mediated by the ERK1/2 (extracellular-signal regulated kinase 1/2) signaling pathway. PMID: 23991041
- The present study has sought to investigate the extent of vascular dysfunction and oxidant formation in glutathione peroxidase-1-deficient (GPx-1(-/-)) mice during the aging process with special emphasis on dysregulation of the endothelial NO synthase. PMID: 24296279
- GPx-1-PTP1B-PP2A axis plays a critical role in countering the inflammatory and proteolytic responses that result in lung-tissue destruction in response to cigarette smoke exposure. PMID: 23590304
- How does oxidative stress contribute to vascular disease? Data from vascular smooth muscle suggest that reduced GPx1 activity (i.e., increased oxidative stress) promotes secretion of cyclophilin A which mediates paracrine inflammation of vasculature. PMID: 21782974
- Candidate colitis genes in the Gdac1 locus of mice deficient in glutathione peroxidase-1 and -2, were analyzed. PMID: 22970191
- GPx1, an important antioxidant enzyme of the premature retina, afforded protection against oxidative stress and oxidative injury in ROP. PMID: 23287791
- Dietary selenium deficiency precluded the overproduction of glutathione peroxidase-1 in full-fed over-expressing mice and partially rescued their metabolic syndromes. PMID: 23014491
- The peroxidase activity is the main mechanism for Prdx6 antioxidant function, these results indicate that the PLA(2) activity also plays a substantial role in protecting cells against oxidant stress caused by an exogenous hydroperoxide. PMID: 22067043
- gpx-1 primes pro-inflammatory cytokine production after LPS challenge in vivo. PMID: 22412999
- Gpx1 mRNA expression is higher in female than male early after birth. PMID: 22326323
- Our data reveal a structural and kinetic mechanism for the in vivo functional dependence of GPX1 on SOD1 in mammals. PMID: 21420488
- The data indicate glutathione peroxidase GPX1 levels is decreased in stem cell-like characteristics. PMID: 21347610
- molecular events contributing to neuron injury after transient cerebral ischemia; data imply absence of Gpx1 induces activation of compensatory signaling mechanisms reducing oxidative stress without potentiating transduction of existing activated pathways PMID: 21193029
- GPx1-dependent control of intracellular ROS accumulation is important not only for regulation of Th cell proliferation but also for modulation of differentiation into Th1, Th2, and Th17 cells. PMID: 20367278
- Data show that dietary selenium deficiency exhibits a hypoinsulinemic trend in GPX1-overexpressing mice and a strong hypolipidemic effect in the liver of WT mice. PMID: 20578960
- Data show that knockout of SOD1 impaired islet function, pancreas integrity, and body glucose homeostasis more than that of GPX1. PMID: 20586612
- Gpx1 regulates leukocyte-endothelial cell interactions in the cerebral microvasculature, but that this is affected by the nature of the inflammatory insult. PMID: 21166922
- Loss of Gpx1 is associated with diet induced severe colitis. PMID: 20848490
- In GPx2 KO mice, an increase in GPx1 can only partially compensate for GPx2, even under selenium supplementation, indicating that GPx2 is the major antiapoptotic GPx in the colon. PMID: 20828612
- knockout of SOD1 and (or) GPX1 did not potentiate the LPS-induced liver injury, but delayed the induced hepatic glutathione depletion and plasma NO production. PMID: 21145306
- Gpx-1 protects against cigarette smoke-induced lung inflammation, and agents that mimic the actions of gpx-1 may have therapeutic utility in inflammatory lung diseases where cigarette smoke plays a role. PMID: 20511341
- Report the role of GPx1 in protecting cardiac mitochondria against reoxygenation damage in vivo. PMID: 20306076
- Glutathione peroxidase deficiency exacerbates ischemia-reperfusion injury in male but not female myocardium: insights into antioxidant compensatory mechanisms. PMID: 19801492
- Results indicate that Gpx1 deficiency accelerates cardiac hypertrophy and dysfunction but has no effect on vascular hypertrophy and mean arterial blood pressure PMID: 19917877
- Yam was found to increase the activities of superoxide dismutase and glutathione peroxidase in brain. PMID: 19885949
- In vivo antioxidant role of glutathione peroxidase: evidence from knockout mice. PMID: 11898410
- Glutathione peroxidase-1 has a role in modulating molecular pathways involved in both cell death and inflammatory cascades in brain following injury. PMID: 12429206
- Deficiency of GPx-1 exacerbates endothelial dysfunction in hyperhomocysteinemic mice and demonstrates support for the hypothesis that hyperhomocysteinemia contributes to endothelial dysfunction through a peroxide-dependent oxidative mechanism. PMID: 12482825
- Data show that phospho-c-Jun N-terminal kinase may catalyze phosphorylation of p53 protein in Se-deficient mouse liver, and that this cascade is attenuated by low levels of glutathione peroxidase 1. PMID: 12492400
- GPX1 can exert a potent role in defending against liver aponecrosis induced by moderate oxidative stress PMID: 12654481
- Gpx1 functions as the primary protection against acute oxidative stress PMID: 12804009
- Gpx1 is protective against both ROS-mediated senescence-like changes and oxidant-mediated cell death PMID: 14732290
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