Gene References into Functions |
- BoNT/A antinociceptive activity is dependent on integrity of SP/NKA and NK1R. PMID: 28673722
- results indicate the contribution of NK1R signaling in maintaining the homeostasis of the ocular surface under steady-state condition, and that the lack of functional NK1R increases the susceptibility of eyes to develop severe herpes stromal keratitis upon ocular HSV-1 infection PMID: 27798158
- the NK1R-CreER mouse line is a valuable new tool for conditional gene manipulation enabling the visualization and manipulation of cells that express NK1R. PMID: 27712014
- NK1R-/- mice did not exhibit excessive false alarms, compared with wildtypes (response disinhibition) but, as in the 5-Choice ContinuousPerformance Test, they exhibited more perseverative responses throughout the test PMID: 26522842
- NK1R-expressing dorsal horn neurons play a major role in the expression of symptoms of chronic itch. PMID: 25830923
- The results of this study indicated that certain behaviours, disrupted in ADHD, are influenced by an interaction between the BRAS and NK1R, and suggest that ACE inhibitors could provide a novel treatment for this disorder. PMID: 25703442
- the hyperactivity, perseveration and, possibly, inattentiveness of NK1R-/- mice is a direct consequence of a lack of functional NK1R PMID: 25558794
- Arsenic may initiate endothelial dysfunction, resulting in vascular leakage in response to vasoactive agents. PMID: 24448713
- NK1-R expression in the trachea, bronchus, and lung tissue increased in MP-infected BALB/c mice, which may explain why wheezing occurs after MP infection. PMID: 25366726
- The behavioural response of mice lacking NK1r to guanfacine resembles its clinical profile in treatment of ADHD PMID: 25074741
- Together, our findings revealed a critical role of microglial NOX2 in mediating the neuroinflammatory and dopaminergic neurodegenerative effects of SP, which may provide new insights into the pathogenesis of PD. PMID: 25209287
- Both PACAP and SP/NKA, but not NK1 receptors participate in normal motor coordination. PMID: 23499760
- obese-asthma phenotype in mice is accompanied by increased expression of NK1-R on adipose tissues and lung epithelium, reflecting that SP released during inflammation may act directly on these tissues. Blocking NK1-R affects lymphangiogenesis PMID: 23792204
- bone marrow taken from NK-1R deficient mice (Tacr1(-/-)) showed lineage specific B and T cell engraftment deficits compared to wild-type competitor bone marrow cells PMID: 23516556
- Data indicate that NK1R-dendritic cells (DCs) promote cellular immunity that requires IL-12p70. PMID: 23365459
- Data from knockout mice suggest that disruption of NK1R signaling in attention deficit hyperactivity disorder could lead to drug resistance to calcium channel blockers specific for L-type channels. PMID: 22884624
- By activation of the NK1R receptors, it is possible to up-regulate the expression of substance P and NK1R in a protein kinase C, mitogen activated protein kinase, nuclear factor kappa b dependant pathway. PMID: 22040127
- male TACR1 (-/-) mice exhibited blunted approach behavior toward females following the initial interaction compared with C57BL/6 mice. NK-1R signaling may therefore play an important role in pheromone-induced sexual behavior. PMID: 22471406
- This review presented that the NK-1 RECEPTOR knockout mice show a correlation between 5-HT firing rate and PMID: 23089640
- The present studies indicate that alterations in substance P/NK1 receptor system underlie, at least in part, the behavioural and monoaminergic changes in this animal model of depression. PMID: 22155476
- These results indicate that deletion of the NK1 receptor does not alter behavioural susceptibility to chronic repeated stress in mice, but accelerates adaptation of the HPA axis. PMID: 22019828
- assessed the effects of substance P on weight gain in response to a high-fat diet and determined glucose metabolism in Tac1-deficient (Tac1(-/-)) mice PMID: 22009727
- Methamphetamine induces trafficking of striatal neuokinin-1 receptor which is dependent on the activity of dopamine D1 and D2 receptors. PMID: 20730802
- Knockdown of the NK-1R gene in bile duct ligated (BDL) mice induces a decrease in the number of large cholangiocytes (associated with enhanced biliary apoptosis) compared with BDL wild-type mice. PMID: 21596993
- In addition to locomotor hyperactivity, NK1R-/- mice express inattentiveness, perseveration and impulsivity in the 5-choice serial reaction-time task. PMID: 21408181
- results suggest that cigarette smoke produces alveolar macrophages' NK1R overexpression primarily by both promoting neurogenic substance P (SP) release and synergizing NK1R response to neurogenic SP largely via activating NF-kappaB pathway PMID: 20426532
- our proposal that NK1R-/- mice offer a mouse model of ADHD was borne out by our human studies, which suggest that DNA sequence changes in and around the TACR1 gene increase susceptibility to this disorder PMID: 19204064
- Substance P receptor mediated macrophage responses. PMID: 11727773
- substance p-induced bladder inflammation was mast cell dependent and did not require NK1R expression on the mast cell PMID: 12217852
- splenocytes and granuloma cells from neurokinin-1 receptor knockout mice made less interferon-gamma and IgG2a PMID: 12388184
- Loss of NK1 receptors has little effect on chemoreceptor function in the mouse, and thus they play, at best, a minor role in the hypoxic chemoreception process. PMID: 12473075
- Increased respiration after hypoxia was unchanged in NK1-/- neonates but was weaker in adult NK1-/- mice. NK1 receptors aren't needed for prenatal development of the respiratory network or for increased breathing by short-lasting hypoxia in neonates. PMID: 12492418
- increased NK-1 receptor gene expression contributes to the development and maintenance of a hyperalgesic state PMID: 12535787
- Genetic elimination of substance P receptors in mice results in an increased gamma-herpesvirus burden and an altered host response. PMID: 12594288
- Tachykinin NK1 receptor genes are expressed in uterine cells, oocytes, ovaries and embryos from mice, and may play a role in female reproductive function. PMID: 12773411
- protease-activated receptor 2 agonists induced a contraction of murine intestinal smooth muscle that was mediated by nerves and requires both neurokinin 1 and 2 receptors PMID: 12801882
- Restraint stress results in increased dura mater mast cell activation in C57BL mice, but not in neurokinin (NK)-1 receptor knockout mice; stress triggers mast cell activation in dura mater through the activation of NK-1 receptors. PMID: 12867261
- Increased time-dependent expression of the NK1 receptor occurs on bone marrow mast cells after coculture with the cytokines IL-4 and/or stem cell factor and is of functional relevance for the activation of mast cells. PMID: 12902513
- These observations suggest that the amygdala is an important area for the effects of substance P and the NK1 receptor in the motivational properties of opiates, as well as the control of behaviors related to anxiety PMID: 12967989
- NK1 receptors are important in the accurate intensity coding of suprathreshold stimuli. PMID: 14614952
- In an inflammatory model of complete Freund's adjuvant-induced hyperalgesia, substantial reductions in swelling, histological outcome and mechanical hyperalgesia are observed in mice lacking the NK-1 receptor. PMID: 14625445
- Deletion of tachykinin NK1 receptor gene does not alter respiratory network maturation but alters respiratory responses to hypoxia. PMID: 14635705
- Time-limited overexpression of neurokinin-1 receptors in mucosal repair tissue of corpus and antrum. Neurokinin-1 receptors may be involved in gastric wound healing. PMID: 14988833
- peripheral nerve injury increases the expression of substance P (NK-1) receptors in the spinal cord dorsal horn; this is correlated with heat hypersensitivity. PMID: 15042514
- NK-1R and NK-2R have important but differential roles in the regulation of cutaneous inflammatory responses PMID: 15084523
- a significant higher number of corporra lutea in the NK1-R deficient mice in comparison to the wild-type group. PMID: 15236323
- We found NK1 receptors in dopaminergic amacrine cells, indicating that SP neurotransmission may be a universal feature of the circuitry of the dopaminergic amacrine cell. PMID: 15381281
- Effect of receptor expression on mast cell development and their association with mast cells in stomach and bladder tissues. PMID: 15458971
- Activation of NK1 receptors is involved in the maintenance of the inhibitory tone of substantia gelatinosa interneurons. PMID: 15494183
- Separate distributions and the postnatal changes in SP and NK1R suggest the possibility of another nociceptive afferent transmission mechanism, that is, volume transmission, in the Vc other than synapse-mediated transmission. PMID: 15763273
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