Recombinant Human 5-hydroxytryptamine receptor 1B(HTR1B) (Active)

1. Involvement of HTR1B variants in ADHD susceptibility as well as in externalizing and internalizing comorbidities, considering sex differences. PMID: 28923721
2. The polymorphism of HTR1B C861G is not a risk factor for Tourette's in Han Chinese population. PMID: 26123080
3. Acute tryptophan depletion (ATD) did not significantly influence participants' sensitivity to probability, wins, or losses, although there was a trend for a lower tendency to choose experimental gambles overall following depletion. Following ATD, participants with higher peripheral 5-HT1B transcription levels increased choice of experimental gambles and used information pertaining to possible wins more when making choices PMID: 27638901
4. This study found several promoter variants in linkage disequilibrium that may potentially influence the allelic imbalance in the C861G variant. aAnd no evidence of allelic imbalance nor parent-of-origin effects of the C861G variant was observed in suicidal behavior. PMID: 28445878
5. Single nucleotide polymorphism in HTR1B gene is associated with Attention deficit hyperactivity disorder. PMID: 28512748
6. nine ADHD candidate single nucleotide polymorphisms (SNPs) in seven genes were tested for association with PD in 5333 cases and 12,019 healthy controls. No significant association was observed. PMID: 28176268
7. results highlight the importance of HTR1 in leukemogenesis and LSC survival and identify this receptor family as a new target for therapy in AML with prognostic value PMID: 28193998
8. HTR polymorphisms related to vulnerability to major depressive disorder (MDD) and MDD with suicidal attempts. PMID: 28007644
9. The results of this study give new evidence for the role of epigenetic and genetic factors which could modulate HTR1B expression in the pharmacological response to antidepressants. PMID: 28025020
10. 5-HT1B receptor-dependent cellular Src-related kinase-Nox1-pathways contribute to vascular remodeling in pulmonary arterial hypertension. PMID: 28473438
11. preliminary findings suggest a role of the HTR1B gene in susceptibility to development of bulimia nervosa subtypes. Furthermore, this gene might have an impact on the severity of anxiety in anorexia nervosa-spectrum patients. PMID: 27579596
12. Polymorphic variants of the HTR1B gene are associated with the susceptibility of secondary RP in vibration-exposed occupational populations of Chinese Han people. PMID: 26639766
13. large scale neural activation differences in the inferior and medial frontal and temporal/parietal regions of the response inhibition network between the different variants of both the HTR1B and 5HTT genes; activation in these regions was significantly associated with stop-task performance, but not with ADHD diagnosis or severity PMID: 26428549
14. Results from Parkinson's disease patients and MPTP-lesioned monkeys argue in favor of a contribution of 5-HT1B receptors in the pathophysiology of levodopa-induced motor complications PMID: 26254863
15. The interaction between two major serotonergic structures involved in serotonin release, the SERT and 5-HT1B receptor, results in a modification of the inhibitory serotonergic tone mediated via 5-HT1A receptors. PMID: 25652393
16. Serotonin 1B Receptor Gene (HTR1B) Methylation as a Risk Factor for Callous-Unemotional Traits in Antisocial Boys PMID: 25993020
17. Down-regulation of 5-HT1B and 5-HT1D receptors inhibits proliferation, clonogenicity and invasion of human pancreatic cancer cells. PMID: 25268648
18. reductions in 5-HT1B availability found in this study suggest that 5-HT1B receptors may contribute to the etiology or expression of cocaine dependence and potentially represent a target for medication development. PMID: 24433854
19. 5-HT1B- and 5-HT1D-mediated signaling play an important role in the regulation of the proliferative and invasive phenotype of pancreatic cancer cells. PMID: 25170871
20. Genetic variation in HTR1B predicts changes in bone metabolism during SSRI use. PMID: 24074042
21. HTR1B SNPs significantly associate with early-onset obsessive compulsive disorder. PMID: 24571444
22. Low level of 5-HT(1B)receptors in limbic system corelates to decreased serotonin function in patients with Parkinson disease.(review) PMID: 24126162
23. HTR1B SNP rs6296 was associated with childhood aggressive behavior but not with adulthood anger or hostility. The HTR1B SNP rs6296 modified the association between childhood aggressive behavior and adulthood hostility. PMID: 22945537
24. 5-HT inhibits pulmonary artery smooth muscle cell apoptosis via pERK1/2, PDK, 5-HT1B, 5-HTT pathway. PMID: 23601559
25. Alterations in 5HT1B-receptor density were found to be differentially linked to a novel, five-factor model of posttraumatic stress disorder symptoms. PMID: 22584868
26. An association between the sexual dimension of aging males' syndrome and genetic variants of 5-HTR1B G861C is observed. PMID: 23485949
27. Brain 5-HT1B receptor occupancy with zolmitriptan is demonstrated. PMID: 23430984
28. In a Turkish population of migraine patients no genetic association with 5-HT1B polymorphisms is found. PMID: 23375453
29. These results cannot provide support for an important function of TPH1 and HTR1B in the pathogenesis of sclerosing bone dysplasias. PMID: 23563356
30. This meta-analysis supports the associations of HTR1B -261T>G and -161A>T with alcohol and drug abuse and further investigations are warranted in larger samples. PMID: 23335468
31. The results of this study concluded that SSRIs reduce attention in older adults, particularly in those with high-expression genetic variants at the 1B receptors. PMID: 22717018
32. HTR1B genotypes AA & AT are associated with a lower age of onset of smoking in women than the TT genotype. PMID: 23177301
33. crystal structures of the 5-HT1B G protein-coupled receptor bound to the agonist antimigraine medications ergotamine and dihydroergotamine PMID: 23519210
34. Epistatic interactions between presynaptic components (5HTR1B and SLC6A4) as reported are likely to regulate serotonin levels in the synapse and impact treatment for ADHD. PMID: 22575343
35. The CC genotype of HTR1B G681C polymorphism had higher cortisol and prolactin responses and higher platelet-rich plasma serotonin in health volunteers but this was not observed in nonresponsive OCD with the same genotype after chronic SRI treatment. PMID: 22522758
36. age is a relevant factor for 5-HT(1B) in the cortex of healthy adults PMID: 22851636
37. Preliminary data imply that the genetic variants of the 5-HT1B receptor might be associated with prostate cancer PMID: 22420486
38. Neither the 5-HTTLPR gene nor the 5-HT1B G861C polymorphism alone is a risk factor for antisocial alcoholism in Taiwan's Han Chinese population, but that the interaction between both genes may increase susceptibility to antisocial alcoholism. PMID: 22550993
39. our findings point to an association between functional variants in the promoter region of the HTR1B gene and alcohol dependence, supporting previous neurobiological evidences of the involvement of HTR1B variations in alcohol-related phenotypes. PMID: 22005095
40. two SNPs, both serotonin receptor 5-HT(1B) linked, had a significant main effect on ejaculation latency time. PMID: 22240001
41. Selective inhibition of 5-HT2A by sarpogrelate stimulated angiogenesis, restoring ischemic limb blood perfusion in a severe diabetic mouse model through stimulation of the eNOS/Akt pathway via the endothelial 5-HT1B receptor. PMID: 22172591
42. There was a statistically significant association with Body Mass Index at HTR1B single nucleotide polymorphism rs4140535 in African Americans but not in Caucasians. PMID: 22106445
43. genetic association studies in Ireland/Northern Ireland: SNPs in HTR1B and OPRmu1 genes are associated with subgroups of subjects with alcohol dependence distinguished by age of onset. PMID: 21906503
44. These findings point to a role for HTR(1B) polymorphism in heroin dependence among Han Chinese, and may be informative for future genetic or neurobiological studies on heroin dependence. PMID: 21839728
45. Sumatriptan and tegaserod were more potent at the 124Cys-variant h5-HT1B receptor PMID: 21478802
46. findings suggest that allelic variability in SLC1A2/3, 5-HTR1B and NTRK2 may be relevant to the underlying diathesis for suicidal acts. PMID: 21711518
47. The HTR1B A-161T polymorphism may be particularly valuable as a functional genetic marker for alcoholis PMID: 21172311
48. our findings suggest abnormally reduced function of ventral striatum/ventral pallidum 5-HT1B receptors in humans with major depressive disorder PMID: 20480149
49. This study found haplotype of HTR1B gene that was significantly more frequent in worman then in mam. PMID: 20674037
50. There was no assocition of HTR1B with adolescent idiopathic scoliosis. PMID: 20388441
51. Our results provide additional evidence that HRT1B gene may be an important risk factor for the development of ADHD, but this effect seems not to be attributable to inattentive cases. PMID: 19756364
52. findings extend our understanding of the genetic basis of anger and hostility by showing that newly characterized HTR1B haplotypes, particularly those with rs13212041, which modulates microRNA-mediated regulation of HTR1B expression PMID: 19350534
53. This study indicated that the HTR1B gene might be involved in the development of suicidal ideation in MD among a Chinese Han population. PMID: 19897250
54. Genetic variability of the 5HT1B receptor is involved in the development of some type of alcohol dependence. PMID: 11956970
55. a potential susceptibility locus at the 5-HT(1B) receptor gene in attention deficit hyperactivity disorder PMID: 12192616
56. substance abuse disorder and major depression appear to be associated with the 5-HT1B receptor G861C locus in the patient population, but other psychopathologies such as bipolar disorder, schizophrenia, alcoholism, and suicide attempts were not PMID: 12496953
57. may be a good candidate for genetic studies of ADHD. PMID: 12556913
58. G861C, G261T, and C129T are not playing any direct role in the development of susceptibility to alcoholism PMID: 12898580
59. Population-based association study tested the hypothesis that the serotonin 1B receptor (HTR1B) A-161T polymorphisms was associated with TPQ personality trait scores in a sample population of 209 young healthy Chinese. PMID: 14504413
60. HTR1B is the target of substantial transcriptional genetic regulation by common haplotypes, which are in linkage disequalibrium with the HTR1B single-nucleotide polymorphism (SNP) most commonly used in association studies. PMID: 14593427
61. Based on the examination of 164 alcoholic subjects, an association is found between a lower frequency of the 5-HT1B 861cytosine allele, antisocial personality traits and conduct disorder in alcohol-dependent subjects. PMID: 14714219
62. Alterations in 5-HT(1A,) 5-HT(1B), and 5-HT(2A) mRNA levels in the brains of subjects with both mood disorders and schizophrenia support the hypothesis of dysregulation of the serotonergic system in these psychiatric disorders. PMID: 14744462
63. Not significantly associated with aggression. (5HT1Dbeta receptor) PMID: 15318027
64. Evidence is provided for mismatch of 5-HT1B receptor mRNA expression and receptor distribution in human brain, giving support to species differences in the cortical mRNA expression and localization of this receptor subtype. PMID: 15700286
65. this is the first association study to suggest how a particular gene might influence OCD pathology in an eating disorder population. PMID: 15944142
66. Postsynaptic 5-HT(1B) receptors directly influence the executive, consummatory phases of agonistic behavior, whereas presynaptic serotonergic feedback systems are particularly useful in the introductory phases of the agonistic behavioral complex. PMID: 16310769
67. results of the present study indicate that the dynamic modulation of 5-HT1B receptor function by p11 may be involved in molecular adaptations occurring in neuronal networks that are dysfunctional in depression-like states PMID: 16400147
68. The contribution of 5-HT1B receptors to the mediation of the effects of 5-HT is increased in 124Cys/Phe individuals. PMID: 16847428
69. lack of association of obsessive behaviors/perfectionism and the HTR1B gene in a sample of 203 families with an ADHD proband PMID: 16958036
70. antagonism of the 5-HT(1B) receptor inhibits the proliferation of both human and murine primary helper T cells and of human helper T cell lines PMID: 17011639
71. investigate seven genetic variants in three genes (serotonin transporter (5-HTT), serotonin receptor 1B (5-HTR1B) and serotonin receptor 2A (5-HTR2A)), which have previously been shown to be associated with ADHD PMID: 17093889
72. The 5-HT1B receptor promoter polymorphism G861C plays a role in headache intensity. PMID: 17417740
73. Genetic variation of the serotonin 1B receptor gene is associated with impulsive aggressive behavior and suicide PMID: 17510950
74. there was no significant association between the HTR1B G861C polymorphism and suicidal behavior (Meta-Analysis) PMID: 17525973
75. a G-G haplotype (rs1213368-rs6296) and the respective G-alleles were found to be related to a strong loudness dependence of auditory evoked potentials response of the left tangential dipole, indicating low serotonergic activity PMID: 17948897
76. Individuals homozygous for the ancestral A-element reported more conduct-disorder behaviors than individuals with the G-element PMID: 18283276
77. Examination of genetic variants at the HTR1B locus indicated no association between the selected polymorphisms and childhood-onset mood disorder. PMID: 18349694
78. In the human internal thoracic artery, 5-hydroxytryptamine (5-HT)-induced vasoconstriction is mediated by activation of both 5-HT2A and 5-HT1B receptors. PMID: 18430065
79. findings showed evidence of undertransmission of the HTR1B haplotypes containing alleles -161G and -261A at HTR1B gene to autism spectrum disorders (ASD) (P=0.003), but no involvement of HTR2C to the predisposition to ASD PMID: 19038234
80. the 5HT1B gene A-161T polymorphism alone is not a risk factor for increasing susceptibility to either alcohol dependence or its subtypes PMID: 19519719
81. There were no significant differences between groups in genotype or haplotype distribution of HTR1B markers in Borderline personality disorder. PMID: 19626271

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HGNC: 5287

OMIM: 182131

KEGG: hsa:3351

STRING: 9606.ENSP00000358963

UniGene: Hs.123016