ABCC11 Antibody

Datasheet
Code CSB-PA846641ESR1HU
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Uniprot No. Q96J66
Image
  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA846641ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human breast cancer using CSB-PA846641ESR1HU at dilution of 1:100

Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunogen Recombinant Human ATP-binding cassette sub-family C member 11 protein (1-170AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Relevance Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.
Form Liquid
Conjugate Non-conjugated
Storage Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Method Antigen Affinity Purified
Isotype IgG
Clonality Polyclonal
Alias ATP-binding cassette sub-family C member 11 (Multidrug resistance-associated protein 8), ABCC11, MRP8
Immunogen Species Human
Research Area Signal Transduction
Target Names ABCC11
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides
Subcellular Location Cell membrane, Multi-pass membrane protein, Vacuole membrane, Cytoplasmic vesicle membrane
Protein Families ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Tissue Specificity Expressed in ceruminous apocrine gland (at protein level) (PubMed:19383836, PubMed:19710689). Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis
Database Links

HGNC: 14639

OMIM: 117800

KEGG: hsa:85320

STRING: 9606.ENSP00000349017

UniGene: Hs.652267

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