Recombinant Human ATP-binding cassette sub-family C member 11 protein (1-170AA)
ELISA, IHC; Recommended dilution: IHC:1:20-1:200
Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Enhances the cellular extrusion of cAMP and cGMP. Stimulates the ATP-dependent uptake of a range of physiological and synthetic lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Probably functions to secrete earwax.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Antigen Affinity Purified
ATP-binding cassette sub-family C member 11 (Multidrug resistance-associated protein 8), ABCC11, MRP8
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Expressed in ceruminous apocrine gland (at protein level) (PubMed:19383836, PubMed:19710689). Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis