Recombinant Human ATP-binding cassette sub-family C member 11(ABCC11) ,partial

Code CSB-YP846641HU
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Source Yeast
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Code CSB-EP846641HU
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Source E.coli
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Code CSB-EP846641HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP846641HU
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Source Baculovirus
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Code CSB-MP846641HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names ABCC11
Uniprot No. Q96J66
Alternative Names ABCC 11; ABCC11; ABCCB_HUMAN; ATP binding cassette protein C11; ATP binding cassette sub family C (CFTR/MRP) member 11; ATP binding cassette sub family C member 11; ATP binding cassette transporter MRP8; ATP binding cassette transporter sub family C member 11; ATP-binding cassette sub-family C member 11; EWWD; MRP8; Multi resistance protein 8; Multidrug resistance associated protein 8; Multidrug resistance-associated protein 8; OTTHUMP00000164191; WW
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Participates in physiological processes involving bile acids, conjugated steroids and cyclic nucleotides. Stimulates the ATP-dependent uptake of a range of physiological lipophilic anions, including the glutathione S-conjugates leukotriene C4 and dinitrophenyl S-glutathione, steroid sulfates such as dehydroepiandrosterone 3-sulfate (DHEAS) and estrone 3-sulfate, glucuronides such as estradiol 17-beta-D-glucuronide (E(2)17betaG), the monoanionic bile acids glycocholate and taurocholate, and methotrexate. Enhances also the cellular extrusion of cAMP and cGMP. Confers resistance to anticancer drugs, such as 5-fluorouracil (5-FU) and methotrexate. Probably functions to secrete earwax. Required for the secretion of components contributing to axillary odor formation.
Gene References into Functions
  1. The previous findings of a previously unreported homozygous genotype for both the Delta27 and A alleles suggest that the Delta27 deletion might have occurred in the A allele of ABCC11 gene with the 538G>A mutation. PMID: 30047321
  2. our study has provided conclusive evidence for the association of rs17822931 in the ABCC11 with the susceptibility of AO in the Chinese Han population PMID: 28485377
  3. Serum levels of MRP8/MRP14 and MRP6 were up-regulated in patients with Graves' disease (GD) and Hashimoto's thyroiditis (HT). In addition, mRNA expression of MRP proteins in PBMCs and the thyroid gland was markedly elevated in these patients. PMID: 29656212
  4. High MRP8 expression is associated with Rheumatoid Arthritis. PMID: 29530998
  5. ABCC11 c.1637C>T polymorphisms affects fluoropyrimidine toxicity to leukocytes PMID: 27001120
  6. Our results confirmed the association between NAF yield and earwax phenotype through ABCC11 genotype. Combined with the recency of last birth, ABCC11 genotype should be considered in the design of studies utilizing NAF as a biosample. PMID: 27027309
  7. Tenofovir disoproxil fumarate is a new substrate of ABCC11. PMID: 28167562
  8. These results suggest that N-linked glycosylation is important for the protein stability of ABCC11, and physiological alteration in glucose may affect the ABCC11 protein level and ABCC11-related phenotypes in humans, such as axillary osmidrosis. PMID: 27281343
  9. The present study shows that the protein expression of ABCC10 significantly associates with overall survival and the expression of ABCC11 with disease-free interval of colorectal cancer patients PMID: 27468921
  10. ABCC11 protein was detected in the human axillary apocrine glands of the 538GG homozygote or 538GA heterozygote, not in the 538AA homozygote. These findings would contribute to a better understanding of the molecular basis of axillary osmidrosis. PMID: 28212277
  11. No Association of the rs17822931 Polymorphism in ABCC11 was found with Breast Cancer Risk in Koreans. PMID: 27268641
  12. Presents a simple isothermal genotyping method capable of detecting single nucleotide polymorphisms in the human ATP-binding cassette transporter ABCC11 gene and its application to the clinical diagnosis of axillary osmidrosis. PMID: 27057547
  13. identified c.1637C>T (T546M), previously associated with 5-FU-related toxicity, as a novel functionally damaging ABCC11 variant exhibiting markedly reduced transport function of 5-FdUMP, the active cytotoxic metabolite of 5-FU. Detailed analysis of 14 subpopulations revealed highest allele frequencies of c.1637C>T in Europeans and Americans (up to 11%) compared with Africans and Asians (up to 3%). PMID: 25896536
  14. The ABCC11 gene SNP of the 538 G>A allele was associated with a downregulation of the mRNA expression of ApoD in the apocrine glands, which may indicate a role for the ABCC11 gene in the mediation of osmidrosis PMID: 25633187
  15. A single nucleotide polymorphism in ABCC11 affects the cerumen volatile organic compounds profiles of individuals from African, Caucasian, and Asian descent. PMID: 25501636
  16. role in the generation of axillary malodour PMID: 24533866
  17. ABCC11 gene SNP results in lower levels of axillary odour in the A/A homozygotes, but A/A subjects still produce noticeable amounts of axillary odour. Axillary skin metabolites/bacterial genera/personal hygiene behaviours are also influenced by this SNP. PMID: 24076068
  18. The rs17822931 SNP in ABCC11 is associated with wet earwax and bromhidrosis in a chinese family. PMID: 23970085
  19. Our results suggest that a specific type of toxicity, leukopenia, is associated with a particular variant of ABCC11, which is different from the earwax and eQTL variants. PMID: 24024896
  20. High expression of ATP-binding cassette transporter ABCC11 in breast tumors is associated with aggressive subtypes and low disease-free survival. PMID: 23288347
  21. Cerumen types, determined by CYP2D6 and the incidence of breast cancer is significantly higher among the moist cerumen type. Further studies on the polymorphism of this gene are scheduled in relation to carcinogenesis and malignancy. PMID: 23350374
  22. overview of the discovery and genetic polymorphisms inABCC11; focus on the impact of ABCC11 538G>A on the apocrine phenotype, patients' response to nucleoside-based chemotherapy and the potential risk of breast cancer [review] PMID: 21182469
  23. The expression of ABCC11 protein appears to be decreased in most breast cancer (BC). PMID: 21423094
  24. Earwax-associated polymorphism in ABCC11 is not associated with breast cancer. PMID: 21165769
  25. Data show that latitude is associated with allele frequency of ABCC11 rs17822931-A in Asian, Native American, and European populations, implying that the selective advantage of rs17822931-A is related to an adaptation to a cold climate. PMID: 20937735
  26. Study shows that Japanese women with wet earwax have a higher relative risk of developing breast cancer than those with dry earwax. The ABCC11 SNPs that determine these phenotypes should be further investigated. PMID: 21187511
  27. Results showed that ABCC11 may be one of the biomarkers for MTA treatment in adenocarcinomas. PMID: 20718756
  28. The SmartAmp method-based genotyping of the ABCC11 gene would provide an accurate and practical tool for guidance of appropriate treatment PMID: 19625231
  29. ABCC11 has a role in the biochemical formation of human axillary odor PMID: 19710689
  30. The allele frequencies of the ABCC11 locus within ancient populations on the Northern Japanese island of Hokkaido, were investigated. PMID: 19557017
  31. alternative splice variants and gene expression PMID: 11688999
  32. Impaired 2',3'-dideoxy-3'-thiacytidine accumulation in T-lymphoblastoid cells as a mechanism of acquired resistance independent of multidrug resistant protein 4 with a possible role for ATP-binding cassette C11. PMID: 12133003
  33. Results suggest that MRP8 participates in physiological processes involving bile acids, conjugated steroids, and cyclic nucleotides and indicate that this pump has complex interactions with its substrates. PMID: 15537867
  34. Transport function together with the localization of the ABCC11 protein in vicinity to GABA A receptors is consistent with a role of ABCC11 in dehydroepiandrosterone 3-sulfate release from neurons. PMID: 16359813
  35. An SNP, 538G --> A (rs17822931), in the ABCC11 gene is responsible for determination of earwax type in several ethnic groups. PMID: 16444273
  36. High expression of MRP8 is associated with reduced intracellular levels of cytosine arabinoside and results in acute myeloid leukemia. PMID: 19240178
  37. Data suggest that a single-nucleotide polymorphism in the ABCC11 gene has an effect on the N-linked glycosylation of ABCC11, intracellular sorting, and proteasomal degradation of the variant protein. PMID: 19383836
  38. Wet/dry types of earwax are determined by the c.538G>A single-nucleotide polymorphism in the ABCC11 gene. PMID: 19644513

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Subcellular Location Cell membrane; Multi-pass membrane protein. Vacuole membrane. Cytoplasmic vesicle membrane. Apical cell membrane; Multi-pass membrane protein.
Protein Families ABC transporter superfamily, ABCC family, Conjugate transporter (TC 3.A.1.208) subfamily
Tissue Specificity Expressed in ceruminous apocrine gland (at protein level). Expressed in many tissues. Not expressed in kidney, spleen and colon. Highly expressed in breast cancer. Expressed at moderate levels in normal breast and testis and at very low levels in liver, b
Database Links

HGNC: 14639

OMIM: 117800

KEGG: hsa:85320

STRING: 9606.ENSP00000349017

UniGene: Hs.652267

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