CDCA8 Antibody

Code CSB-PA700653ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human lung cancer using CSB-PA700653ESR2HU at dilution of 1: 100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) CDCA8 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
BOR antibody; BOREA_HUMAN antibody; Borealin antibody; CDCA8 antibody; Cell division cycle associated 8 antibody; cell division cycle associated protein 8 antibody; Cell division cycle-associated protein 8 antibody; Dasra B antibody; Dasra-B antibody; DasraB antibody; FLJ10468 antibody; FLJ12042 antibody; hDasra B antibody; hDasra-B antibody; MESRGP antibody; OTTHUMP00000004514 antibody; pluripotent embryonic stem cell related gene 3 protein antibody; Pluripotent embryonic stem cell-related gene 3 protein antibody
Raised in
Species Reactivity
Recombinant Human Borealin protein (1-280AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Tested Applications
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Major effector of the TTK kinase in the control of attachment-error-correction and chromosome alignment.
Gene References into Functions
  1. Results show that CDCA8 is overexpressed in bladder cancer (BC) and its high levels are correlated with poor clinicopathological features of BC patients. Therefore, CDCA8 may act as a novel prognostic marker in the diagnosis of patients with BC. PMID: 30142792
  2. These results were well correlated with the same gene expression pattern analysed in the thyroid tissue of the patient with BOREALIN-p.R114W. These studies open new avenues in the genetics of TD in humans. PMID: 28025328
  3. Borealin dimerization mediates chromosomal passenger complex checkpoint function by enhancing localization to centromeres and kinetochores. PMID: 25854549
  4. enhanced CDCA8 promoter activities by NF-Y overexpression and reduced CDCA8 transcription by NF-Y knockdown further verified that NF-Y is a positive regulator of CDCA8 transcription. PMID: 26170459
  5. In colorectal cancer patients, Borealin expression was positively correlated with age, lymph node metastasis and neoplasm staging. PMID: 25260804
  6. These findings reveal a previously unrecognized but direct link between HP1 and CPC localization in the centromere and illustrate the critical role of borealin-HP1 interaction in orchestrating an accurate cell division. PMID: 24917673
  7. Borealin interacts directly with the Snf7 components of ESCRT-III in human cells.the Borealin central region encompassing residues 110-207 was both necessary & sufficient to bind to CHMP4C. PMID: 22724069
  8. MLL5 functionally interacts with Borealin, facilitates the expression of chromosomal passenger complex, and hence contributes to mitotic fidelity and genomic integrity. PMID: 22797924
  9. important role for phosphorylation of Borealin at S219 in the proper progression through mitosis PMID: 20803554
  10. Data show that INCENP has an important role in stabilizing the chromosomal passenger complex, and that Borealin acts to promote binding of Survivin to INCENP. PMID: 16239925
  11. Cell cycle-regulated chromosomal passenger protein whose aberrant expression and nuclear accumulation are linked to poor prognosis for gastric cancer. PMID: 16427043
  12. A functional module within the chromosomal passenger complex involving the inner centromere protein INCENP, Survivin, and Borealin. PMID: 16571674
  13. Borealin is phosphorylated during mitosis. Neither residue S165, T106 nor phosphorylation of borealin by Aurora B Kinase is required to generate the mitotic, shifted form of Borealin. PMID: 17241471
  14. Suppression of CDCA8 expression with small interfering RNA against CDCA8 significantly suppressed the growth of lung cancer cells. PMID: 17483322
  15. It is recorded that borealin is a cell cycle regulator, down-regulated in response to p53/Rb-signaling, and up-regulated in many types of cancerous tissues. PMID: 17716930
  16. mitotic regulator Survivin binds as a monomer to its functional interactor Borealin PMID: 17881355
  17. Borealin and INCENP associate with the helical domain of Survivin to form a tight three-helical bundle. PMID: 17956729
  18. Borealin plays a crucial role in the early mouse embryonic development PMID: 18311593
  19. Data describe a mitotic SUMO2/3 conjugation-deconjugation cycle of Borealin and further assign a regulatory function of RanBP2 and SENP3 in the mitotic SUMO pathway. PMID: 18946085
  20. found that substitutions at Borealin T230, recently identified as an Mps1 phosphorylation site, can modulate the dimerization state of Borealin PMID: 19530738

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Subcellular Location
Nucleus, nucleolus. Cytoplasm. Cytoplasm, cytoskeleton, spindle. Chromosome, centromere.
Protein Families
Borealin family
Database Links

HGNC: 14629

OMIM: 609977

KEGG: hsa:55143

STRING: 9606.ENSP00000316121

UniGene: Hs.524571

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