DPY30 Antibody

1. Dpy30 role in cellular reprogramming and its interactions with Set1 complex PMID: 26691508
2. results indicate that DPY30 has critical roles in the proliferation, migration, and invasion of gastric cancer cells, and suggest DPY30 might be a therapeutic target in gastric cancer PMID: 26147337
3. Based on our structural data and cross-linking results, we suggest that Dpy30 may regulate H3K4 methylation according to its copy number in COMPASS PMID: 25542209
4. these results form the basis for understanding how WRAD(DRY-30) differentially regulates SET1 family complexes in vivo. PMID: 25561738
5. The DPY30 subunit in SET1/MLL complexes regulates the proliferation and differentiation of hematopoietic progenitor cells. PMID: 25139354
6. A deletion mutation and reduced DPY30 expression in a Spastic Paraplegia type 4 Japanese family. PMID: 24690193
7. DPY30 regulates pathways in cellular senescence through ID protein expression. PMID: 23872946
8. determination of the minimum motif of Ash2L that is required for DPY30 interaction; a structural model for the Ash2L-DPY30 interaction PMID: 22231628
9. First report of SPG4 associated with partial deletions of both the SPAST and DPY30 genes. The partial heterozygous deletion of DPY30 could modify the phenotypic expression of SPG4 patients with this pedigree. PMID: 20857310
10. The DPY-30 C-terminal domain structure, harboring the conserved DPY-30 motif, is composed of two alpha-helices linked by a sharp loop and forms a typical X-type four-helix bundle required for dimer formation. PMID: 19481096
11. hDPY-30 (dpy-30-like protein) binds ASH2L directly. The evolutionarily conserved hDPY-30, ASH2L, RBBP5 and WDR5 likely constitute a subcomplex that is shared by all human Set1-like HMT complexes. PMID: 17500065

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HGNC: 24590

OMIM: 612032

KEGG: hsa:84661

STRING: 9606.ENSP00000295066

UniGene: Hs.531788