ITGA7 Antibody, Biotin conjugated

Code CSB-PA618797LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ITGA7 Polyclonal antibody
Uniprot No.
Target Names
ITGA7
Alternative Names
alpha 7 antibody; FLJ25220 antibody; Integrin alpha 7 antibody; Integrin alpha 7 chain antibody; Integrin alpha 7 heavy chain antibody; Integrin alpha 7 light chain antibody; Integrin alpha-7 70 kDa form antibody; ITA7_HUMAN antibody; ITGA 7 antibody; Itga7 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Integrin alpha-7 protein (175-283AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Integrin alpha-7/beta-1 is the primary laminin receptor on skeletal myoblasts and adult myofibers. During myogenic differentiation, it may induce changes in the shape and mobility of myoblasts, and facilitate their localization at laminin-rich sites of secondary fiber formation. It is involved in the maintenance of the myofibers cytoarchitecture as well as for their anchorage, viability and functional integrity. Isoform Alpha-7X2B and isoform Alpha-7X1B promote myoblast migration on laminin 1 and laminin 2/4, but isoform Alpha-7X1B is less active on laminin 1 (In vitro). Acts as Schwann cell receptor for laminin-2. Acts as a receptor of COMP and mediates its effect on vascular smooth muscle cells (VSMCs) maturation. Required to promote contractile phenotype acquisition in differentiated airway smooth muscle (ASM) cells.
Gene References into Functions
  1. Speculate that the postnatal splicing of alpha7A to alpha7B and of beta1A to beta1D integrins is delayed, altering spontaneous descent of the testes in the first months of life. PMID: 30089289
  2. As knockdown of Integrin alpha7 (ITGA7) can effectively reduce the stemness of oesophageal squamous cell carcinoma (OSCC) cells, ITGA7 could be a potential therapeutic target in OSCC treatment. PMID: 27924820
  3. targeting of ITGA7 by RNAi or blocking mAbs impaired laminin-induced signaling, and it led to a significant delay in tumor engraftment plus a strong reduction in tumor size and invasion. PMID: 28602620
  4. Taken together, these results further support the use of a7 integrin as a potential therapy for Duchenne muscular dystrophy PMID: 26076707
  5. Data indicate that S100 calcium binding protein P (S100P) increased lung cancer cell migration by binding integrin alpha7. PMID: 26320193
  6. Data suggest that ITGA7 is an epigenetically regulated tumour suppressor gene and a prognostic factor in human malignant pleural mesothelioma. PMID: 26011651
  7. ITGA7 binds to tissue inhibitor of metalloproteinase 3 (TIMP3) in prostate cancer cells. PMID: 23830872
  8. The absence of either alpha7beta1 integrin or alpha6beta1 integrin impairs the ability of Schwann cells to spread and to bind laminin. PMID: 24227711
  9. Digenic mutational inheritance of the integrin alpha 7 and the myosin heavy chain 7B genes causes congenital myopathy with left ventricular non-compact cardiomyopathy. [ITGA7] PMID: 23800289
  10. Alpha7beta1D integrin modifies Ca2+ regulatory pathways and offers a means to protect the myocardium from ischemic injury. PMID: 24091324
  11. This report provides a novel insight into the mechanism, involving interaction with high temperature requirement A2, by which ITGA7 acts as a tumor suppressor. PMID: 20651226
  12. ILK interaction with MCM7 and MCM7 phosphorylation may be a critical event in ITGA7 signaling pathway, leading to tumor suppression. PMID: 20460506
  13. conclude that secondary integrin alpha 7 deficiency is rather common in muscular dystrophy/myopathy of unknown etiology PMID: 12057917
  14. FHL2 and FHL3, respectively, are colocalized with alpha(7)beta(1) integrin receptor at the periphery of Z-discs, suggesting a role in mechanical stabilization of muscle cells PMID: 15117962
  15. alpha7-expressing fetal myoblasts are capable of differentiation to osteoblast lineage with a coordinated switch in integrin profiles and may represent a mechanism that promotes homing and recruitment of myogenic stem cells for tissue remodeling. PMID: 17054947
  16. Integrin alpha7 mutations are associated with prostate cancer, liver cancer, glioblastoma multiforme, and leiomyosarcoma PMID: 17551147
  17. analysis of how distinct acidic clusters and hydrophobic residues in the alternative splice domains X1 and X2 of alpha7 integrins define specificity for laminin isoforms PMID: 17618648
  18. Alpha7B is a novel marker of the contractile phenotype, and alpha7 expression is essential for human airway smooth muscle cell maturation, which is a laminin-dependent process. PMID: 17641293
  19. cleavage is a novel mechanism that regulates alpha7 integrin functions in skeletal muscle, and that the generation of such cleavage sites is another evolutionary mechanism for expanding and modifying protein functions. PMID: 18940796
  20. laminin-111 (alpha(1), beta(1), gamma(1)), which is expressed during embryonic development but absent in normal or dystrophic skeletal muscle, increased alpha(7)-integrin expression in mouse and DMD patient myoblasts PMID: 19416897

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Involvement in disease
Muscular dystrophy congenital due to integrin alpha-7 deficiency (MDCI)
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Integrin alpha chain family
Tissue Specificity
Isoforms containing segment A are predominantly expressed in skeletal muscle. Isoforms containing segment B are abundantly expressed in skeletal muscle, moderately in cardiac muscle, small intestine, colon, ovary and prostate and weakly in lung and testes
Database Links

HGNC: 6143

OMIM: 600536

KEGG: hsa:3679

STRING: 9606.ENSP00000452120

UniGene: Hs.524484

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