MAP4K4 Antibody

Code CSB-PA002905
Size US$100
  • Western Blot analysis of HuvEc cells using HGK Polyclonal Antibody
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Product Details

Uniprot No.
Target Names
Alternative Names
FLH21957 antibody; FLJ10410 antibody; FLJ20373 antibody; FLJ90111 antibody; Hepatocyte progenitor kinase like/germinal center kinase like kinase antibody; HGK antibody; HPK/GCK like kinase antibody; HPK/GCK like kinase HGK antibody; HPK/GCK-like kinase HGK antibody; KIAA0687 antibody; M4K4_HUMAN antibody; MAP4K4 antibody; MAPK/ERK kinase kinase kinase 4 antibody; MEK kinase kinase 4 antibody; MEKKK 4 antibody; MEKKK4 antibody; Mitogen activated protein kinase kinase kinase kinase 4 antibody; Mitogen-activated protein kinase kinase kinase kinase 4 antibody; Nck interacting kinase antibody; Nck-interacting kinase antibody; NIK antibody
Raised in
Species Reactivity
Synthesized peptide derived from the Internal region of Human HGK.
Immunogen Species
Homo sapiens (Human)
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
It differs from different batches. Please contact us to confirm it.
Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
Tested Applications
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:2000
IF 1:200-1:1000
ELISA 1:40000
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322.
Gene References into Functions
  1. an anti-cancer effect of microRNA-141 on breast cancer by cytotoxic CD4+ T cells through MAP4K4 expression. PMID: 29620289
  2. the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta/smad signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells. PMID: 28771231
  3. RBM4-SRSF3-MAP4K4 constitutes a novel mechanism for manipulating the metastasis of colorectal cancer cells through the JNK1 signaling pathway. PMID: 29138007
  4. these findings identify MAP4K4 as a novel MAPK/ERK pathway regulator in lung adenocarcinoma that is required for lung adenocarcinoma maintenance. PMID: 28306189
  5. This report identifies HGK methylation/downregulation in T cells as a potential biomarker for non-obese type 2 diabetes PMID: 26918832
  6. Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate. PMID: 27044870
  7. of the five variants, SNP rs2236935T/C was significantly associated with type 2 diabetes mellitus (T2DM) in this study population; conclude that MAP4K4 gene is associated with T2DM in a Chinese Han population, and MAP4K4 gene variants may contribute to the risk toward the development of T2DM PMID: 27174326
  8. Interactions between MAP4K4 gene variants and environmental factors may contribute to MAP4K4 attenuation in T cells, leading to non-obese T2D. PMID: 28061846
  9. MAP4K4 promotes the epithelial-mesenchymal transition and invasiveness of hepatocellular carcinoma cells PMID: 27010469
  10. miR-194 regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of MAP4K4 PMID: 26722431
  11. The results of the present study suggested that inhibition of MAP4K4 may be a therapeutic strategy for gastric cancer. PMID: 26549737
  12. loss of MAP4K4 function suppressed pathological angiogenesis in disease models, identifying MAP4K4 as a potential therapeutic target PMID: 25799996
  13. that MAP4K4, a known mediator of inflammation, is involved in KS aetiology by regulating KSHV lytic reactivation PMID: 24244164
  14. results reveal a key target of SOX2 expression and highlight the unexpected context-dependent role for MAP4K4, a pluripotent activator of several mitogen-activated protein kinase pathways, in regulating tumor cell survival. PMID: 24233838
  15. TRAF1.NIK is a central complex linking canonical and non-canonical pathways by disrupting the TRAF2-cIAP2 ubiquitin ligase complex PMID: 23543740
  16. Common polymorphisms in MAP4K4 are associated with insulin resistance and beta-cell dysfunction, possibly via this gene's role in inflammatory signaling. PMID: 23094072
  17. Elevated MAP4K4 expression is closely associated with lung adenocarcinoma progression with independent prognostic value in predicting overall survival for patients with lung adenocarcinoma. PMID: 22824148
  18. MAP4K4 overexpression is an independent predictor of poor prognosis of Hepatocellular Carcinoma patients, and inhibition of its expression might be of therapeutic significance PMID: 21196414
  19. Data show that down-regulation of hepatocyte progenitor kinase-like kinase (HGK) can obviously inhibit the migration and invasion of HepG2 cells in vitro, and suggest that HGK may be a new therapeutic target for treatment of hepatocellular carcinoma. PMID: 20857524
  20. interaction with GBP3 PMID: 12387898
  21. The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. PMID: 12612079
  22. MAP4K4 is a putative effector of Rap2, a Ras family small GTP-binding protein, mediating the activation of JNK by Rap2 PMID: 14966141
  23. studies of the promigratory role of MAP4K4 showed that the knockdown of this transcript inhibited the migration of multiple carcinoma cell lines, indicating a broad role in cell motility PMID: 16537454
  24. MAP4K4 silencing prevents TNFa-induced insulin resistance in human skeletal muscle and restores appropriate signaling inputs to enhance glucose uptake PMID: 17227768
  25. MAP4K4 expression significantly correlated with overall and recurrence-free survival (P=0.025 and 0.004) independent of age, tumor size, differentiation, and stage. PMID: 18981001

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Subcellular Location
Protein Families
Protein kinase superfamily, STE Ser/Thr protein kinase family, STE20 subfamily
Tissue Specificity
Widely expressed. Isoform 5 is abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta.
Database Links

HGNC: 6866

OMIM: 604666

KEGG: hsa:9448

STRING: 9606.ENSP00000314363

UniGene: Hs.701013

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