MAP4K4 Antibody

1. an anti-cancer effect of microRNA-141 on breast cancer by cytotoxic CD4+ T cells through MAP4K4 expression. PMID: 29620289
2. the close proximity between AcSDKP and FGFR1 was essential for the suppression of TGFbeta/smad signaling and EndMT associated with MAP4K4 phosphorylation (P-MAP4K4) in endothelial cells. PMID: 28771231
3. RBM4-SRSF3-MAP4K4 constitutes a novel mechanism for manipulating the metastasis of colorectal cancer cells through the JNK1 signaling pathway. PMID: 29138007
4. these findings identify MAP4K4 as a novel MAPK/ERK pathway regulator in lung adenocarcinoma that is required for lung adenocarcinoma maintenance. PMID: 28306189
5. This report identifies HGK methylation/downregulation in T cells as a potential biomarker for non-obese type 2 diabetes PMID: 26918832
6. Results reveal that endothelial Map4k4 is critical for lymphatic vascular development by regulating endothelial cells (EC)quiescence and lymphatic EC fate. PMID: 27044870
7. of the five variants, SNP rs2236935T/C was significantly associated with type 2 diabetes mellitus (T2DM) in this study population; conclude that MAP4K4 gene is associated with T2DM in a Chinese Han population, and MAP4K4 gene variants may contribute to the risk toward the development of T2DM PMID: 27174326
8. Interactions between MAP4K4 gene variants and environmental factors may contribute to MAP4K4 attenuation in T cells, leading to non-obese T2D. PMID: 28061846
9. MAP4K4 promotes the epithelial-mesenchymal transition and invasiveness of hepatocellular carcinoma cells PMID: 27010469
10. miR-194 regulated the progression of hepatocellular carcinoma through directly inhibiting the expression of MAP4K4 PMID: 26722431
11. The results of the present study suggested that inhibition of MAP4K4 may be a therapeutic strategy for gastric cancer. PMID: 26549737
12. loss of MAP4K4 function suppressed pathological angiogenesis in disease models, identifying MAP4K4 as a potential therapeutic target PMID: 25799996
13. that MAP4K4, a known mediator of inflammation, is involved in KS aetiology by regulating KSHV lytic reactivation PMID: 24244164
14. results reveal a key target of SOX2 expression and highlight the unexpected context-dependent role for MAP4K4, a pluripotent activator of several mitogen-activated protein kinase pathways, in regulating tumor cell survival. PMID: 24233838
15. TRAF1.NIK is a central complex linking canonical and non-canonical pathways by disrupting the TRAF2-cIAP2 ubiquitin ligase complex PMID: 23543740
16. Common polymorphisms in MAP4K4 are associated with insulin resistance and beta-cell dysfunction, possibly via this gene's role in inflammatory signaling. PMID: 23094072
17. Elevated MAP4K4 expression is closely associated with lung adenocarcinoma progression with independent prognostic value in predicting overall survival for patients with lung adenocarcinoma. PMID: 22824148
18. MAP4K4 overexpression is an independent predictor of poor prognosis of Hepatocellular Carcinoma patients, and inhibition of its expression might be of therapeutic significance PMID: 21196414
19. Data show that down-regulation of hepatocyte progenitor kinase-like kinase (HGK) can obviously inhibit the migration and invasion of HepG2 cells in vitro, and suggest that HGK may be a new therapeutic target for treatment of hepatocellular carcinoma. PMID: 20857524
20. interaction with GBP3 PMID: 12387898
21. The STE20 kinase HGK is broadly expressed in human tumor cells and can modulate cellular transformation, invasion, and adhesion. PMID: 12612079
22. MAP4K4 is a putative effector of Rap2, a Ras family small GTP-binding protein, mediating the activation of JNK by Rap2 PMID: 14966141
23. studies of the promigratory role of MAP4K4 showed that the knockdown of this transcript inhibited the migration of multiple carcinoma cell lines, indicating a broad role in cell motility PMID: 16537454
24. MAP4K4 silencing prevents TNFa-induced insulin resistance in human skeletal muscle and restores appropriate signaling inputs to enhance glucose uptake PMID: 17227768
25. MAP4K4 expression significantly correlated with overall and recurrence-free survival (P=0.025 and 0.004) independent of age, tumor size, differentiation, and stage. PMID: 18981001

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HGNC: 6866

OMIM: 604666

KEGG: hsa:9448

STRING: 9606.ENSP00000314363

UniGene: Hs.701013