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The NELFB antibody (CSB-PA03765A0Rb) is produced in the rabbit with a peptide corresponding to amino acids 8-199 of the human NELFB immunized. This polyclonal antibody occurs as an unconjugated IgG. Its purity is 95%+ using protein G purified. It is reactive with human and mouse samples. The NELFB protein is a subunit of NELF, which is known to enforce promoter-proximal pausing of RNA polymerase II. The functional cardiac deterioration in NELFB knockout mice strongly indicates an important role of NELFB in the maintenance of normal cardiac contractility under stressed conditions. This anti-NELFB antibody has been quality-verified in ELISA, WB, IHC, and ChIP applications.
|Full Product Name||Rabbit anti-Homo sapiens (Human) NELFB Polyclonal antibody|
NELFB antibody; COBRA1 antibody; KIAA1182 antibody; Negative elongation factor B antibody; NELF-B antibody; Cofactor of BRCA1 antibody
|Species Reactivity||Human, Mouse|
|Immunogen||Recombinant Human Negative elongation factor B protein (8-199AA)|
|Immunogen Species||Homo sapiens (Human)|
The NELFB Antibody (Product code: CSB-PA03765A0Rb) is Non-conjugated. For NELFB Antibody with conjugates, please check the following table.
|Purification Method||>95%, Protein G purified|
|Concentration||It differs from different batches. Please contact us to confirm it.|
|Buffer||Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
|Tested Applications||ELISA, WB, IHC, ChIP|
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Native Chromatin Immunoprecipitation(ChIP) Protocol
|Troubleshooting and FAQs||Antibody FAQs|
|Storage||Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.|
|Lead Time||Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.|
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Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex. May be able to induce chromatin unfolding. Essential for early embryogenesis; plays an important role in maintaining the undifferentiated state of embryonic stem cells (ESCs) by preventing unscheduled expression of developmental genes. Plays a key role in establishing the responsiveness of stem cells to developmental cues; facilitates plasticity and cell fate commitment in ESCs by establishing the appropriate expression level of signaling molecules. Supports the transcription of genes involved in energy metabolism in cardiomyocytes; facilitates the association of transcription initiation factors with the promoters of the metabolism-related genes.; (Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II. In vitro, binds weakly to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1.
|Gene References into Functions||
|Protein Families||NELF-B family|
|Tissue Specificity||Widely expressed. Expressed in heart, brain, lung, placenta, liver, skeletal muscle, kidney and pancreas.|