NFIL3 Antibody

Code CSB-PA093754
Size US$297
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  • Western blot analysis of extracts from 293 cells and K562 cells, using NFIL3 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NFIL3 Polyclonal antibody
Uniprot No.
Target Names
NFIL3
Alternative Names
E4 promoter binding protein 4 antibody; E4 promoter-binding protein 4 antibody; E4BP 4 antibody; E4BP4 antibody; E4BP4 protein antibody; IL3BP 1 antibody; IL3BP1 antibody; Interleukin 3 binding protein 1 antibody; Interleukin 3 promoter transcriptional activator antibody; Interleukin-3 promoter transcriptional activator antibody; Interleukin-3-binding protein 1 antibody; NFIL 3 antibody; NFIL 3A antibody; NFIL3 antibody; NFIL3_HUMAN antibody; NFIL3A antibody; Nuclear factor interleukin 3 regulated antibody; Nuclear factor interleukin-3-regulated protein antibody; Transcriptional activator NF IL3A antibody; Transcriptional activator NF-IL3A antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse,Rat
Immunogen
Synthesized peptide derived from internal of Human NFIL3.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,WB
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:3000
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts. Represses transcriptional activity of PER1. Represses transcriptional activity of PER2 via the B-site on the promoter. Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock. Protects pro-B cells from programmed cell death. Represses the transcription of CYP2A5. Positively regulates the expression and activity of CES2 by antagonizing the repressive action of NR1D1 on CES2. Required for the development of natural killer cell precursors.
Gene References into Functions
  1. data provide evidence that E4BP4 attenuates RASSF8-mediated anti-proliferation and apoptosis, shedding mechanistic insights into RASSF8 down-regulation in breast cancers. PMID: 29467226
  2. Here we review the regulatory mechanisms of E4BP4 engaging in not only the biological function but also the development of immune-mediated diseases, paving the way for future therapies PMID: 28365317
  3. glucocorticoid-mediated transactivating pathway may support eosinophil viability in IL-5-stimulated cells through synergistic upregulation of NFIL3 PMID: 26880402
  4. E4BP4 and BIM regulation correlated with that of RCAN1-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1-1 PMID: 26102033
  5. Results conclude that the transcriptional repressor E4BP4 plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 silencing. PMID: 25338303
  6. NFIL3 plays a neuroprotective role in neurons and constitutes a potential therapeutic target for neurodegeneration. PMID: 24280221
  7. Data indicate that E4BP4 can inhibit CD40L expression through epigenetic modifications in the promoter region of CD40L. PMID: 23340290
  8. NFIL3 alters cancer cell behavior and FOXO function by acting on chromatin to restrict the menu of FOXO target genes PMID: 23630076
  9. The clock-regulated and immune system modulator transcription factor E4BP4/ NFIL3 likely regulates the expression of both appb in zebrafish and APP in humans. PMID: 22947103
  10. G9a mediates E4BP4-dependent suppression of hepatic Fgf21 by enhancing histone methylation (H3K9me2) of the Fgf21 promoter PMID: 23283977
  11. Conclude that E4BP4 plays as a survival factor in heart and E4BP4 is essential for proper embryonic heart development. PMID: 20186462
  12. This report demonstrates that GC-mediated upregulation of the bZIP transcriptional repressor gene, E4BP4, is dependent on [Ca2+]i levels, and correlates with GC-evoked apoptosis of GC-sensitive CEM-C7-14 cells. PMID: 16630563
  13. E4BP4 has a role as osteoblast transcriptional repressor in inhibiting both Runx2 and Osterix in myeloma bone disease PMID: 18829486
  14. Identification of adjacent binding sites for the YY1 and E4BP4 transcription factors in the PrP (Prion) gene promoter. PMID: 19129193

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Subcellular Location
Nucleus.
Protein Families
BZIP family, NFIL3 subfamily
Tissue Specificity
Expressed in bladder stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and muscle.
Database Links

HGNC: 7787

OMIM: 605327

KEGG: hsa:4783

STRING: 9606.ENSP00000297689

UniGene: Hs.79334

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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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