NLRP12 Antibody

Code CSB-PA069966
Size US$166
  • The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using CSB-PA069966(NLRP12 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
  • The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA069966(NLRP12 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details

Uniprot No.
Target Names
Alternative Names
CLR19.3 antibody; FCAS2 antibody; Monarch 1 antibody; Monarch-1 antibody; NACHT, leucine rich repeat and PYD containing 12 antibody; NACHT, LRR and PYD containing protein 12 antibody; NACHT, LRR and PYD domains-containing protein 12 antibody; NAL12_HUMAN antibody; NLR family, pyrin domain containing 12 antibody; NLRP12 antibody; Nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12 antibody; OTTHUMP00000067227 antibody; PAN6 antibody; PYPAF7 antibody; PYRIN containing APAF1 like protein 7 antibody; PYRIN-containing APAF1-like protein 7 antibody; Regulated by nitric oxide antibody; RNO antibody; RNO2 antibody
Raised in
Species Reactivity
Synthetic peptide of Human NLRP12
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen affinity purification
It differs from different batches. Please contact us to confirm it.
-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol
Tested Applications
Recommended Dilution
Application Recommended Dilution
ELISA 1:1000-1:2000
IHC 1:25-1:100
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Inhibits also the DDX58-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked DDX58 activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked DDX58 degradation. Acts also as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue.
Gene References into Functions
  1. Patients with NLRP12 germline mutations and diagnosis of NLRP12-related autoinflammatory disease demonstrated highly variable clinical phenotypes. PMID: 29500522
  2. report the crystal structure of NLRP12 PYD domain at 1.70 A fused with an maltose-binding protein (MBP) tag PMID: 29293680
  3. all of the reported mutations were found to have occurred in a highly conserved region in the NACHT domain coding sequence in NLRP12 exon 3, suggesting that a screening strategy for Familial cold autoinflammatory syndrome should focus on this area of the gene PMID: 27314497
  4. The novel findings reveal the critical role of NLRP12-IL-17A-CXCL1 axis in host defense by modulating neutrophil recruitment against Klebsiella pneumoniae. PMID: 26349659
  5. This process involved the upregulation of NLRP12. PMID: 26329693
  6. Variants of NLRP12 were associated with common variable immunodeficiency. PMID: 26122175
  7. NLRP12/NLRP3-dependent activation of caspase-1 is likely to be a key event in mediating systemic production of IL-1beta and hypersensitivity to secondary bacterial infection during malaria. PMID: 24453977
  8. The genetics, expression and roles of NLRP12 in inflammatory signaling, host defense, and carcinogenesis are reviewed. Review. PMID: 25249449
  9. This study suggested that NLRP12 mutations might account for a small fraction of common variable immunodeficiency patients with severe auto-inflammatory complications. PMID: 25064839
  10. We will focus on NLRP6 and NLRP12. PMID: 24338634
  11. Letter: NLRP12 mutations associated with familial cold autoinflammatory syndrome 2 in Italian patients. PMID: 24064030
  12. Even with a variable range of associated manifestations, the extreme sensitivity to cold represents the main clinical hallmark in an individual carrying the p.D294E mutation of the NLRP12 gene. PMID: 21360512
  13. The authors report the first in vitro confirmed non-homotypic interaction between NLRP12 pyrin domain and the pro-apoptotic protein Fas-associated factor 1 (FAF-1), which links the innate immune system to apoptotic signaling. PMID: 21978668
  14. NLRP12 missense mutation in periodic fever syndromes; study provides evidence of deleterious effect of an NLRP12 missense mutation; this newly identified molecular defect emphasizes the crucial role played by NLRP12 in autoinflammation PMID: 21538323
  15. regulates activation of NF-kappa B and caspase-1-dependent cytokine processing PMID: 12019269
  16. Monarch-1 enhances nonclassical and classical major histocompatibility complex class I expression at the level of the promoter, RNA, and protein expression. PMID: 12759408
  17. Monarch-1 associates with IRAK-1 but not MyD88, resulting in the blockage of IRAK-1 hyperphosphorylation PMID: 16203735
  18. Monarch-1 inhibits CD40-mediated activation of NF-kappaB via the non-canonical pathway in human monocytes. This inhibition stems from the ability of Monarch-1 to associate with and induce proteasome-mediated degradation of NF-kappaB inducing kinase PMID: 17237370
  19. Heat shock protein 90 is a critical regulator of Monarch-1 anti-inflammatory activity PMID: 17947705
  20. ATP binding by NLRP12 is critical for its inhibitory function. PMID: 18160710
  21. Two mutations, nonsense and splice site, were identified in NALP12 in two families with periodic fever syndromes. PMID: 18230725
  22. Relative copy numbers for the inflammasome mRNAs for ASC, caspase-1, NALP1, and Pypaf-7 were significantly lower in patients with septic shock compared with critically ill control subjects. PMID: 18263805

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Involvement in disease
Familial cold autoinflammatory syndrome 2 (FCAS2)
Subcellular Location
Protein Families
NLRP family
Tissue Specificity
Detected only in peripheral blood leukocytes, predominantly in eosinophils and granulocytes, and at lower levels in monocytes.
Database Links

HGNC: 22938

OMIM: 609648

KEGG: hsa:91662

STRING: 9606.ENSP00000319377

UniGene: Hs.631573

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