Specific families of pattern recognition receptors play a key role in recognizing various pathogens and generating innate immune responses. Nucleotide-binding, oligomerization domain (NOD)-like receptors (NLRs) are a family of cytosolic proteins that play a pivotal role in the recognition of intracellular ligands. The NLR family contains twenty-two human proteins and at least thirty-four mouse proteins that include a central nucleotide-binding, oligomerization domain (NOD or NACHT), an N-terminal protein interaction domain, and a variable number of C-terminal leucine-rich repeats. Similar to the leucine-rich repeat-containing toll-like receptors (TLRs), multiple NLRs function as pattern recognition receptors. These NLRs are responsible for detecting specific pathogen-associated molecules or host-derived damage signals in the cytosol and initiating the innate immune response. NOD1 and NOD2, two prototypic NLRs, are activated by specific components of bacterial peptidoglycan that escaped from endosomal compartments. Their activation triggers several signaling pathways, including the activation of NF-κB and MAPK, cytokine production and apoptosis. Additionally, activation of NOD1 and NOD2 can induce autophagy through an interaction with Autophagy-related 16-like 1 (ATG16L1). On the other hand, a different set of NLRs induces caspase-1 activation through the assembly of multiprotein complexes called inflammasomes. The activated of caspase-1 regulates maturation of the pro-inflammatory cytokines IL-1B, IL-18 and drives pyroptosis. Although a clear connection between NOD1 and chronic inflammatory diseases has not been well-established, mutations in NOD2 have been linked to Crohn's disease and Blau syndrome.
|AIM2||AIM2 Antibody||AIM2 Protein||AIM2 cDNA||AIM2 ELISA Kit|
|ANTXR1||ANTXR1 Antibody||ANTXR1 Protein||ANTXR1 cDNA||ANTXR1 ELISA Kit|
|ANTXR2||ANTXR2 Antibody||ANTXR2 Protein||ANTXR2 cDNA||ANTXR2 ELISA Kit|
|ATG12||ATG12 Antibody||ATG12 Protein||ATG12 cDNA||ATG12 ELISA Kit|
|ATG16L1||ATG16L1 Antibody||ATG16L1 Protein||ATG16L1 cDNA||ATG16L1 ELISA Kit|
|ATG5||ATG5 Antibody||ATG5 Protein||ATG5 cDNA||ATG5 ELISA Kit|
|BCL2||BCL2 Antibody||BCL2 Protein||BCL2 cDNA||BCL2 ELISA Kit|
|BCL2L1||BCL2L1 Antibody||BCL2L1 Protein||BCL2L1 cDNA||BCL2L1 ELISA Kit|
|BIRC2||BIRC2 Antibody||BIRC2 Protein||BIRC2 cDNA||BIRC2 ELISA Kit|
|BIRC3||BIRC3 Antibody||BIRC3 Protein||BIRC3 cDNA||BIRC3 ELISA Kit|
|BRCC3||BRCC3 Antibody||BRCC3 Protein||BRCC3 cDNA||BRCC3 ELISA Kit|
|CAMP||CAMP Antibody||CAMP Protein||CAMP cDNA||CAMP ELISA Kit|
|CARD16||CARD16 Antibody||CARD16 Protein||CARD16 cDNA||CARD16 ELISA Kit|
|CARD17||CARD17 Antibody||CARD17 Protein||CARD17 cDNA||CARD17 ELISA Kit|
|CARD18||CARD18 Antibody||CARD18 Protein||CARD18 cDNA||CARD18 ELISA Kit|
|CARD6||CARD6 Antibody||CARD6 Protein||CARD6 cDNA||CARD6 ELISA Kit|
|CARD8||CARD8 Antibody||CARD8 Protein||CARD8 cDNA||CARD8 ELISA Kit|
|CARD9||CARD9 Antibody||CARD9 Protein||CARD9 cDNA||CARD9 ELISA Kit|
|CASP1||CASP1 Antibody||CASP1 Protein||CASP1 cDNA||CASP1 ELISA Kit|
|CASP12||CASP12 Antibody||CASP12 Protein||CASP12 cDNA||CASP12 ELISA Kit|
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