Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NMNAT2 Polyclonal antibody

Uniprot No.

Q9BZQ4

Target Names

NMNAT2

Alternative Names

C1orf15 antibody; KIAA0479 antibody; MGC2756 antibody; NaMN adenylyltransferase 2 antibody; Nicotinamide mononucleotide adenylyltransferase 2 antibody; Nicotinamide nucleotide adenylyltransferase 2 antibody; Nicotinate-nucleotide adenylyltransferase 2 antibody; NMN adenylyltransferase 2 antibody; NMNA2_HUMAN antibody; NMNAT 2 antibody; Nmnat2 antibody; PNAT 2 antibody; PNAT2 antibody; Pyridine nucleotide adenylyltransferase 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Nicotinamide/nicotinic acid mononucleotide adenylyltransferase 2 protein (1-153AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Target Background

Function

Nicotinamide/nicotinate-nucleotide adenylyltransferase that acts as an axon maintenance factor. Catalyzes the formation of NAD(+) from nicotinamide mononucleotide (NMN) and ATP. Can also use the deamidated form; nicotinic acid mononucleotide (NaMN) as substrate but with a lower efficiency. Cannot use triazofurin monophosphate (TrMP) as substrate. Also catalyzes the reverse reaction, i.e. the pyrophosphorolytic cleavage of NAD(+). For the pyrophosphorolytic activity prefers NAD(+), NADH and NaAD as substrates and degrades nicotinic acid adenine dinucleotide phosphate (NHD) less effectively. Fails to cleave phosphorylated dinucleotides NADP(+), NADPH and NaADP(+). Axon survival factor required for the maintenance of healthy axons: acts by delaying Wallerian axon degeneration, an evolutionarily conserved process that drives the loss of damaged axons.

Gene References into Functions

analyses found that rs10494561, located in the intron region within NMNAT2, was associated with the severity of the prodromal symptoms of psychosis implicitly, mediated through the volume of the left hemisphere of the superior frontal region PMID: 28544218
Data indicate a chaperone function of nicotinamide mononucleotide adenylyl transferase 2 (NMNAT2), independent from its enzymatic activity, and NMNAT2 complexes with heat shock protein 90 (HSP90) to refold aggregated protein substrates. PMID: 27254664
We confirmed association at NMNAT2 and identified independent SMG7 association with systemic lupus erythematosus in European American and Amerindian/Hispanic ancestries. PMID: 26783109
NMNAT2 might participate in tumorigenesis of CRC. PMID: 27218101
Knockdown of NMNAT-2 significantly reduces cellular NAD(+) levels and protects cells from p53-dependent cell death upon DNA damage, suggesting an important functional role of NMNAT-2 in p53-mediated signaling. PMID: 24552824
Nicotinamide mononucleotide adenylyltransferase 2 (NMNAT2) is essential for axon growth and survival. PMID: 24840802
Overexpression of NMNAT2 in colorectal cancer cells renders them sensitive to Tiazofurin antineoplastic action. PMID: 23764899
affects tau phosphorylation by regulating PP2A activity PMID: 23579329
Decreased endogenous NMNAT2 function caused by reduced CREB signaling during pathological insults may be one of underlying mechanisms for neuronal death in tauopathies PMID: 22027994
that overexpression of Nmnat2 in M-cells significantly delayed axon degeneration in vivo PMID: 20857515
Nmnat2 is a neuronal protein peripherally attached to membranes via palmitoylation and suggest that Nmnat2 is transported to synaptic terminals via an endosomal pathway. PMID: 20943658
analysis of isoform-specific targeting and interaction domains in human nicotinamide mononucleotide adenylyltransferases PMID: 20388704
cloning, isolation and kinetics PMID: 12359228
Nicotinamide 5'-mononucleotide adenylyltransferase-2 is markedly expressed in the islets of Langerhans. PMID: 14516279
NMNAT1 is a nuclear protein, whereas NMNAT2 and -3 are localized to the Golgi complex and the mitochondria PMID: 16118205
ATP binds before NMN with Golgi apparatus NMNAT2. NMNH conversion to NADH by NMNAT1 and NMNAT3 occurs at similar rates, conversion by NMNAT2 is much slower. PMID: 17402747

Hide All

Subcellular Location

Golgi apparatus membrane; Lipid-anchor. Cytoplasmic vesicle membrane; Lipid-anchor. Cytoplasm. Cell projection, axon.

Protein Families

Eukaryotic NMN adenylyltransferase family

Tissue Specificity

Highly expressed in brain, in particular in cerebrum, cerebellum, occipital lobe, frontal lobe, temporal lobe and putamen. Also found in the heart, skeletal muscle, pancreas and islets of Langerhans.

Database Links

HGNC: 16789

OMIM: 608701

KEGG: hsa:23057

STRING: 9606.ENSP00000287713

UniGene: Hs.497123