PCMT1 Antibody

Code CSB-PA017618GA01HU
Size $600
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Product Details

Uniprot No.
Target Names
Alternative Names
PCMT1 antibody; Protein-L-isoaspartate(D-aspartate) O-methyltransferase antibody; PIMT antibody; EC antibody; L-isoaspartyl protein carboxyl methyltransferase antibody; Protein L-isoaspartyl/D-aspartyl methyltransferase antibody; Protein-beta-aspartate methyltransferase antibody
Raised in
Species Reactivity
Human PCMT1
Immunogen Species
Homo sapiens (Human)
Purification Method
Antigen Affinity Purified
It differs from different batches. Please contact us to confirm it.
PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Initiates the repair of damaged proteins by catalyzing methyl esterification of L-isoaspartyl and D-aspartyl residues produced by spontaneous isomerization and racemization of L-aspartyl and L-asparaginyl residues in aging peptides and proteins. Acts on EIF4EBP2, microtubule-associated protein 2, calreticulin, clathrin light chains a and b, Ubiquitin C-terminal hydrolase isozyme L1, phosphatidylethanolamine-binding protein 1, stathmin, beta-synuclein and alpha-synuclein.
Gene References into Functions
  1. decrease of PCMT1 significantly increased the proportion of D-Asp residues in PHB1 and had significant and fatal impacts on morphology and functions of the mitochondria, such as ATP production and the mitochondrial fusion-fission system PMID: 27327778
  2. PIMT heterozygosity for R36C, G175R, R17H, or R17S would be detrimental to successful aging, whereas homozygosity (should it ever occur) would produce devastating neuropathology PMID: 28100787
  3. Strong PIMT expression was a predictive marker of poor prognosis for surgically resected lung adenocarcinoma. PMID: 26997432
  4. The data of this study indicated that DA-associated PIMT downregulation is an important event contributing to neuronal cell death PMID: 25800307
  5. ERK2-mediated phosphorylation of transcriptional coactivator binding protein PIMT/NCoA6IP at Ser298 augments hepatic gluconeogenesis. PMID: 24358311
  6. Overexpression of PCMT1 attentuates Mst1 kinase activation and its apoptotic effects in response to hypoxia-induced injury in cardiomyocytes. PMID: 23647599
  7. Data indicate that human PROTEIN ISOASPARTYL METHYLTRANSFERASE (PIMT) can initiate isoAsp conversion to Asp, and is able to restore Arabidopsis PRH75's complex biochemical activity provided isoAsp formation has not led to conformational alterations. PMID: 23903319
  8. Data show six differentially expressed proteins were identified as HSP70, PPIA and alpha-Enolase (up-regulated) S100-A9, PIMT and beta-5 tubulin (down-regulated), most of which had been shown to play a potential role in the pathogenesis of atherosclerosis. PMID: 21839816
  9. The results implied that maternal polymorphisms in PCMT1 might be a potential genetic risk factor for isolated anencephaly in the Chinese population of Lvliang. PMID: 22647835
  10. Study provides new insight into the molecular mechanisms by which PIMT suppresses the p53 activity through carboxyl methylation, and suggests a therapeutic target for cancers. PMID: 22735455
  11. PIMT may act as a co-activator in ERalpha-mediated transcription of TFF1 through its recruitment to the promoter via interacting with ERalpha. PMID: 22382029
  12. Control of PCMT1 expression by microRNA 15a/16-1 may thus represent a late checkpoint in apoptosis regulation PMID: 22033921
  13. A tight cross-regulation exists between ERK and PIMT in regards to their activation and expression during the epithelial mesenchymal transition. PMID: 21841813
  14. study demonstrates a novel role for PIMT as a negative regulator of Abeta peptide formation and a potential protective factor in the pathogenesis of Alzheimer disease PMID: 21372823
  15. Protein L-Isoaspartyl Methyltransferase PMID: 11792715
  16. crystal structure complexed with adenosyl homocysteine (AdoHcy) to 1.6-A resolution PMID: 11847284
  17. Our results showed that the Ile120Val polymorphism of PCMT1 gene is a genetic modifier for the risk of spina bifida. Val/Val genotype was associated with a reduction in risk for spina bifida. PMID: 16256389
  18. A potential role for PIMT in biological processes such as wound healing, cell migration, and tumor metastasis dissemination. PMID: 17167531
  19. These results suggest that PIMT repair of abnormal proteins is necessary to maintain normal MAPK signaling. PMID: 18381200
  20. Four polymorphisms in the protein L-isoaspartyl-O-methyltransferase (PCMT1) gene, encoding a protein repair enzyme, are associated with premature ovarian failure (POF). PMID: 18582870

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Subcellular Location
Cytoplasm, cytosol.
Protein Families
Methyltransferase superfamily, L-isoaspartyl/D-aspartyl protein methyltransferase family
Database Links

HGNC: 8728

OMIM: 176851

KEGG: hsa:5110

STRING: 9606.ENSP00000356348

UniGene: Hs.279257

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