RMI1 Antibody, HRP conjugated

Code CSB-PA875699LB01HU
Size US$166
Order now
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RMI1 Polyclonal antibody
Uniprot No.
Target Names
Alternative Names
BLAP75 antibody; BLM associated polypeptide 75 kDa antibody; BLM associated protein 75 kDa antibody; BLM-associated protein of 75 kDa antibody; C9orf76 antibody; FAAP75 antibody; FLJ12888 antibody; Homolog of yeast RecQ mediated genome instability 1 antibody; RecQ mediated genome instability 1 antibody; RecQ-mediated genome instability protein 1 antibody; Rmi1 antibody; RMI1 homolog antibody; RMI1 RecQ mediated genome instability 1 homolog antibody; RMI1_HUMAN antibody; RP11-346I8 antibody
Raised in
Species Reactivity
Recombinant Human RecQ-mediated genome instability protein 1 protein (181-443AA)
Immunogen Species
Homo sapiens (Human)
Purification Method
>95%, Protein G purified
It differs from different batches. Please contact us to confirm it.
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Tested Applications
Troubleshooting and FAQs
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.
Gene References into Functions
  1. RMI1 knockdown cells exhibit accumulation of broken DNAs after being released from hydroxyurea treatment. Moreover, we demonstrate that RMI1 facilitates the recovery from activated checkpoint and resuming the cell cycle after replicative stress. PMID: 29042194
  2. RMI1 protein level does not change through G1, S and G2 phases, but significantly increases in M phase. PMID: 26556339
  3. a model that maps all functionally important structural features for yeast Rmi1 and structure-prediction-based alignment with the recently established crystal structure of the N-terminus of human Rmi1, is proposed. PMID: 26717309
  4. The results show that Topo IIIalpha stimulates DNA unwinding by BLM in a manner that is potentiated by RMI1-RMI2, and that the processivity of resection is reliant on the Topo IIIalpha-RMI1-RMI2 complex. PMID: 25200081
  5. two proteins that interact with BLM, RMI1 and RMI2, are phosphorylated upon SAC activation, and, like BLM, RMI1, and RMI2, are phosphorylated in an MPS1-dependent manner. PMID: 24108125
  6. RMI1 is required to promote normal replication fork progression PMID: 22645306
  7. Crystal structures of RMI1 and RMI2, two OB-fold regulatory subunits of the BLM complex PMID: 20826342
  8. human topoisomerase IIIalpha functions as a decatenase with the assistance of BLM and RMI1 to facilitate the processing of homologous recombination intermediates without crossing over as a mechanism to preserve genome integrity PMID: 20445207
  9. No evidence was found for an association between RMI1 S455N (rs1982151) and colorectal cancer risk. PMID: 19945966
  10. BLAP75/RMI1 acts by recruiting TOPO IIIalpha to double Holliday junctions PMID: 16537486
  11. BLM, Topo IIIalpha, and BLAP75 constitute a dissolvasome complex that processes HR intermediates to limit DNA crossover formation PMID: 16595695
  12. BLM is stably associated with RMI1 protein. PMID: 17728255
  13. Genetic variant of the human homologous recombination-associated gene RMI1 is associated with acute myeloid leukemia, myelodysplatic syndromes and malignant melanoma PMID: 17900800
  14. evolutionarily conserved N-terminal third of BLAP75 mediates complex formation with BLM and Topo IIIalpha and that the DNA binding activity resides in the C-terminal third of this novel protein. PMID: 18390547
  15. Individuals carrying genetic variants of the BLM-TOP3A-RMI1 complex have an increased risk of acute myeloid leukemia/myelodysplatic syndromes, malignant melanoma, bladder and breast cancer. PMID: 19432957

Show More

Hide All

Subcellular Location
Nucleus. Note=Forms foci in response to DNA damage.
Protein Families
RMI1 family
Database Links

HGNC: 25764

OMIM: 610404

KEGG: hsa:80010

STRING: 9606.ENSP00000317039

UniGene: Hs.726327

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
Place an order now

I. Product details


II. Contact details


III. Ship To


IV. Bill To