ZFHX3 Antibody

Code CSB-PA176078
Size US$297
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  • Immunohistochemistry analysis of paraffin-embedded human brain tissue, using ZFHX3 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) ZFHX3 Polyclonal antibody
Uniprot No.
Target Names
ZFHX3
Alternative Names
ZFHX3 antibody; ATBF1Zinc finger homeobox protein 3 antibody; AT motif-binding factor 1 antibody; AT-binding transcription factor 1 antibody; Alpha-fetoprotein enhancer-binding protein antibody; Zinc finger homeodomain protein 3 antibody; ZFH-3 antibody
Raised in
Rabbit
Species Reactivity
Human,Mouse
Immunogen
Synthesized peptide derived from internal of Human ZFHX3.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcriptional regulator which can act as an activator or a repressor. Inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. In concert with SMAD-dependent TGF-beta signaling can repress the transcription of AFP via its interaction with SMAD2/3. Regulates the circadian locomotor rhythms via transcriptional activation of neuropeptidergic genes which are essential for intercellular synchrony and rhythm amplitude in the suprachiasmatic nucleus (SCN) of the brain. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down-regulates the MUC5AC promoter in gastric cancer. In association with RUNX3, upregulates CDKN1A promoter activity following TGF-beta stimulation. Inhibits estrogen receptor (ESR1) function by selectively competing with coactivator NCOA3 for binding to ESR1 in ESR1-positive breast cancer cells.
Gene References into Functions
  1. alterations in the expression and subcellular localization of ATBF1, as a result of posttranscriptional modifications, are associated with malignant features of colon tumours. PMID: 28713972
  2. Study identified DNA methylation (DNAm) site cg07786668 in ZFHX3 that is independently and significantly associated with myocardial infarction (MI) along with DNAm cg17218495 in SMARCA4. These results suggest that the development of MI might be influenced by changes in DNAm at these sites via a pathway that differs from that affected by cardiovascular disease-associated SNPs in these genes. PMID: 28515798
  3. using in vitro prolactin induced lactogenic differentiation in an HC11 mouse cell model and an in vivo conditional knockout mouse model we showed that mouse Zfhx3 is essential for mouse mammary epithelial cell differentiation and mouse mammary gland development at the lactation stage through regulation of prolactin receptor expression and the downstream Jak2-Stat5 signaling pathway. PMID: 27129249
  4. Increasing experimental data support that ZFHX3 gene plays a critical role in the pathogenesis of atrial fibrillation where it was found up-regulated. [review] PMID: 29126922
  5. We showed that the ZFHX3 polymorphism, rs2106261 (A allele), was a risk marker for atrial fibrillation (A)F and AF-related phenotypes. PMID: 28007413
  6. Nuclear localization of AT-motif binding factor 1 (ATBF1) indicates better prognosis of urothelial carcinoma. PMID: 27756245
  7. Cellular localization of ATBF1 is correlated with its function in breast cancer. Nuclear ATBF1 was co-localized with chromosome during mitosis normally. Estrogen induced translocation of cytoplasmic ATBF1 to nuclei in MCF7. PMID: 28624455
  8. The results suggest an additive effect of ZFHX3 and PTEN deletions on the development and progression of prostate neoplasia PMID: 26233892
  9. Both ZFHX3 and PITX2c regulate expression of NPPA, TBX5 and NKX2.5. PMID: 26267381
  10. In a Caucasian population, genetic variant rs7193343 SNP in ZFHX3 gene is associated with risk of atrial fibrillation. PMID: 26112950
  11. The CAA repeat polymorphism in exon 9 of the ZFHX3 gene contributes to the Coronary heart disease susceptibility in the Chinese population. PMID: 25797214
  12. ZFHX3 defects are associated with poor outcome in endometroid endometrial cancer. PMID: 26330387
  13. Two SNPs (rs2106261, rs6499600) located in gene ZFHX3 showed significant associations with atrial fibrillation in a Chinese Han population. PMID: 24983873
  14. ZFHX3 transcription is regulated in a transcript-specific fashion by independent cis-acting transcribed polymorphisms. PMID: 25539802
  15. A missense mutation in ZFHX3 results in damage to the ZFHX3 protein structure in patients with extreme atrial fibrillation. PMID: 25391453
  16. nuclear localization and SUMOylation are important for the transcription factor function of ATBF1, and that ATBF1 could cooperate with PML NBs to regulate protein SUMOylation in different biological processes. PMID: 24651376
  17. Nuclear localization of ATBF1 is frequently interrupted in HNSCC, and the interruption is significantly associated with the progression of HNSCC PMID: 22791392
  18. based on observations, nuclear ATBF1 staining was associated with low malignancy profiles of skin cancer PMID: 23317484
  19. A polymorphism in the ZFHX3 gene, encoding a cardiac transcription factor, was associated with increased AF risk in HF patients, and the genetic association with AF was more pronounced in HF patients than in the general population. PMID: 23132824
  20. findings indicate that Atbf1 plays a role in the development of pubertal mammary gland likely by modulating the function of estrogen-ER signaling in luminal cells and by modulating gene expression in basal cells PMID: 23251482
  21. These findings suggest that ATBF1 plays a crucial role in the Progesterone-progesterone receptors signaling pathway in mammary epithelial cells. PMID: 23159610
  22. Suppression of ZFHX3 expression in tumor cells decreases the survival rate among patients with NSCLC. PMID: 23144151
  23. 3 loci from related cardiovascular genomewide studies were significant: PHACTR1 in large-vessel disease (P=2.63e(-6)), PITX2 in cardioembolic stroke (P=4.78e(-8)), and ZFHX3 in cardioembolic stroke (P=5.50e(-7)). PMID: 23042660
  24. Levels of ATBF1 protein in breast tumors are positively correlated with the levels of estrogen-responsive finger protein (EFP). PMID: 22452784
  25. gen up-regulates ATBF1 transcription but causes its protein degradation in estrogen receptor-alpha-positive breast cancer cells PMID: 21367855
  26. Our results indicate that the s2106261 SNP in ZFHX3 confers a significant risk of atrial fibrillation in a Chinese Han population. PMID: 21107608
  27. A novel signaling pathway that links ATM via CREB to the transcription factor ZFHX3, which in turn promotes survival of neurons by inducing expression of platelet-derived growth factor receptor beta, is reported. PMID: 20876357
  28. Using DirectDNA sequencing analysis, we detected ATBF1, CYLD, PARK2 and WNT9A mutations in stomach and colorectal cancers PMID: 20854080
  29. ATBF1 associates with RUNX3 and translocates to the nucleus in response to TGF-beta signal transduction and might function in the nucleus as tumor suppressor and transcriptional regulator. PMID: 20599712
  30. Aberrant expression of ATBF1 induces the expression of various factors that are otherwise suppressed, and this somehow determines the biological features of Alpha-fetoprotein producing gastric cancer. PMID: 14654895
  31. In conclusion, ATBF1 can suppress the IL-6-mediated cellular response by acting together with PIAS3. PMID: 14715251
  32. ATBF1-A mRNA has a role in lymph node metastasis of breast neoplasms PMID: 15671546
  33. Somatic mutations of the transcription factor ATBF1 is associated with human prostate cancer PMID: 15750593
  34. Two somatic mutations (shortening of a polypyrimidine tract [Poly(T)n] and a deletion beginning at codon 3381 (3381del)) were each observed in multiple prostate cancer samples and both appear to have an impact on ATBF1 gene function and expression. PMID: 16637072
  35. ATBF1 plays a role in breast cancer through transcriptional downregulation rather than mutations. PMID: 16932943
  36. Results indicate that ATBF1 in the nucleus negatively regulates the MUC5AC gene in gastric cancer by binding to an AT motif-like element in the MUC5AC promoter. PMID: 17330845
  37. Genetic alterations of the ATBF1 gene is associated with gastric cancer PMID: 17671116
  38. The ATBF1 gene may contribute to the development of hepatocellular carcinomas via transcriptional down-regulation of mRNA expression, but not by genetic or epigenetic alterations. PMID: 18312352
  39. ATBF1 and NQO1 as candidate targets for allelic loss at chromosome arm 16q in breast cancer: absence of somatic ATBF1 mutations and no role for the C609T NQO1 polymorphism. PMID: 18416817
  40. ATBF1-A mRNA levels are regulated at the transcriptional stage, but not by genetic mechanisms, deletions (LOH), or mutations. PMID: 18796146
  41. Prostate cancer linkage to the same region of 16q23 has been observed by others and the region contains several strong candidate genes including the known prostate cancer tumor suppressor genes ATBF1 and WWOX. PMID: 19035517
  42. A variant in the ZFHX3 gene on chromosome 16q22, rs7193343-T, associated significantly with atrial fibrillation (odds ratio OR = 1.21, P = 1.4 x 10(-10)). PMID: 19597491
  43. Meta-analyses of 896 prevalent (15,768 referents) and 2,517 incident (21,337 referents) atrial fibrillation (AF) cases identified a new locus for AF (ZFHX3, rs2106261, risk ratio RR = 1.19; P = 2.3 x 10(-7)). PMID: 19597492

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Subcellular Location
Nucleus. Cytoplasm.
Tissue Specificity
Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). Expression is higher in ER-positive breast tumors than ER-negative breast tumors (at protein level).
Database Links

HGNC: 777

OMIM: 104155

KEGG: hsa:463

STRING: 9606.ENSP00000268489

UniGene: Hs.598297

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