Recombinant Human ATP-binding cassette sub-family B member 5(ABCB5) ,partial

Code CSB-YP643574HU
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Source Yeast
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Code CSB-EP643574HU
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Source E.coli
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Code CSB-EP643574HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP643574HU
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Source Baculovirus
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Code CSB-MP643574HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names ABCB5
Uniprot No. Q2M3G0
Alternative Names ABCB 5; ABCB5; ABCB5 P-gp; ABCB5_HUMAN; ABCB5alpha; ABCB5beta; ATP binding cassette protein; ATP binding cassette sub family B (MDR/TAP) member 5; ATP binding cassette sub family B member 5; ATP-binding cassette sub-family B member 5; EST422562; P glycoprotein ABCB5; P-glycoprotein ABCB5
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
(From Uniprot)
Energy-dependent efflux transporter responsible for decreased drug accumulation in multidrug-resistant cells. Specifically present in limbal stem cells, where it plays a key role in corneal development and repair.
Gene References into Functions
  1. Interaction analysis demonstrated that the following genotypes: MS4A14 DI+II, SLC2A DI+II and ABCB 5 CG+GG, were associated with a prothrombin time >/=12 sec and with Recurrent pregnancy loss (RPL) risk PMID: 29956771
  2. No significant influence of the three newly identified ABCB5 polymorphisms. PMID: 26975227
  3. The ABCB5 activates the NF-kappaB pathway by inhibiting p65 ubiquitination to enhance p65 protein stability. PMID: 28821433
  4. Data indicate that the energy metabolism was virtually unaffected by ATP-binding cassette member B5 (ABCB5) expression. PMID: 27560924
  5. The expression of ZEB1 in tissues is positively relevant to ABCB5 in breast cancer. PMID: 28281973
  6. Findings demonstrated that the expression of ABCB5 was upregulated in ocular surface squamous neoplasia (OSSN) and that elevated expression of ABCB5 may be involved in the pathogenesis of OSSN. PMID: 26843453
  7. Human limbal mesenchymal stem cells express ABCB5 and can grow on amniotic membrane. PMID: 26965478
  8. ABCB5 has a role in chemoresistance in Merkel Cell Carcinoma PMID: 26827764
  9. Results suggest that ATP binding cassette subfamily B member 5 ABCB5/Abcb5 upregulates cellular glutathione levels to protect cells from various poisons. PMID: 26666373
  10. ATP-binding cassette member B5 (ABCB5) identifies dermal immunoregulatory cells capable of exerting therapeutic immunoregulatory functions through engagement of programmed cell death 1. PMID: 26321644
  11. This is the first study showing the relationship between miR-340-5p and expression of ABCB5 in melanoma cells PMID: 26554847
  12. c-MYC confers resistance to 5-fluorouracil through regulating ABCB5 expression in human colon cancer cells. PMID: 25689483
  13. ABCB5 alleles alter susceptibility to haloperidol-induced toxicity (HIT) in mouse and humans. PMID: 25647612
  14. The resistance of CD133(+) melanoma subpopulation is attributed to the enhanced drug efflux mediated by ATP-binding cassette sub-family B member 5 (ABCB5), since the knockdown of ABCB5 was found to sensitize CD133(+) cells to CAPE. PMID: 25449786
  15. In melanoma-initiating cells, ABCB5 controls IL1beta secretion, which serves to maintain slow cycling, chemoresistant cells through an IL1beta/IL8/CXCR1 cytokine signaling circuit. PMID: 24934811
  16. Suggest that the helicase HAGE has a key role in the resistance of ABCB5+ malignant melanoma stem cells to IFNalpha treatment by promoting SOCS1 expression. PMID: 24525737
  17. ABCB5 and MDR1 gene expression correlate with drug resistance in acute leukemia patients. PMID: 24804815
  18. ATP-binding cassette, sub-family B, member 5 (ABCB5) marks limbal stem cells (LSCs) and is required for LSC maintenance, corneal development and repair PMID: 25030174
  19. Our results show that ABCB5 is preferentially expressed in the cytotrophoblast layer of placental villi. PMID: 24300535
  20. Novel associations of the ABCB5 K115E polymorphism with human pigmentation phenotype and melanoma risk are observed. PMID: 23770371
  21. Genetically determined ABCB5 functionality correlates with pigmentation phenotype and melanoma risk. Three ABCB5 SNPs, i.e. rs10231520, rs17817117 and rs2301641 (encoding the non-synonymous amino acid change K115E), were associated with decreased clinical melanoma risk. Additionally, the rs2301641 SNP was associated with non-red compared to red human hair color. PMID: 23770371
  22. High ABCB5 expression was significantly associated with tumour progression and recurrence of the tumour. PMID: 22784549
  23. Data show that CD133(+) and ABCB5(+) subpopulations are colocalized in melanomas in perivascular niches that contain CD144 (VE-cadherin)(+) melanoma cells forming vessel-like channels, a phenomenon termed vasculogenic mimicry (VM). PMID: 22865455
  24. The gradual increase in the expression of ABCB5 from benign nevus to in situ to invasive melanoma suggests that it plays a role in melanomagenesis. PMID: 22555176
  25. ABCB5 may be responsible for both the progression and chemotherapeutic refractoriness of advanced acute leukemia. PMID: 22044138
  26. the helicase HAGE is required for ABCB5+ MMIC-dependent tumor growth through promoting RAS protein expression PMID: 22393060
  27. ABCB5 mediates 5-FU resistance in cultured human colorectal cancer cells and affected tumor growth in xenografts. PMID: 21652540
  28. ABCB5 beta may have evolved to play a specific role in human pigment cells and/or melanoma cells where it is predominantly expressed. PMID: 21298007
  29. Results demonstrate that VEGFR-1 expressed by ABCB5+ malignant melanoma initiating cells functions to induce tumor vasculogenic mimicry and associated production of the pro-proliferative melanoma mitogen laminin, thereby promoting tumor growth. PMID: 21212411
  30. Results identify novel T-cell modulatory functions of ABCB5(+) melanoma subpopulations and suggest specific roles for these malignant melanoma initiating cells in the evasion of antitumor immunity and in cancer immunotherapeutic resistance. PMID: 20068175
  31. Expression of GEP and ABCB5 in liver cancer stem cells is associated with chemoresistance and reduced survival times of patients with hepatocellular carcinoma. PMID: 20682318
  32. Tenascin-C promotes melanoma progression by maintaining the ABCB5-positive side population. PMID: 20729912
  33. Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) PMID: 20950786
  34. expression of ABCB 5alpha/beta might possibly provide two novel molecular markers for differential diagnosis of melanomas and constitute potential molecular targets for therapy of melanomas PMID: 15760339
  35. 6-mercaptopurine decreased iNOS expression and increased MRP5 mRNA levels. PMID: 17661346
  36. ABCB5 expression identifies melanoma stem cells and correlates with clinical disease progression in melanoma patients. In vivo targeting of ABCB5+ melanoma stem cells inhibits tumor growth in human to mouse melanoma xenotransplantation models. PMID: 18202660
  37. ABCB5 mediates chemoresistance in stem cell phenotype-expressing human malignant melanoma cells. PMID: 15899824
  38. ABCB5 P-glycoprotein functions include: Regulation of progenitor cell fusion; Regulation of cell membrane potential; Rhodamine-123 transport. PMID: 12960149

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Subcellular Location Cell membrane; Multi-pass membrane protein.
Protein Families ABC transporter superfamily, ABCB family, Multidrug resistance exporter (TC 3.A.1.201) subfamily
Tissue Specificity Expressed by CD133-expressing progenitor cells among epidermal melanocytes (at protein level). Widely expressed with specific expression in pigment cells. Highly expressed in several malignant tissues: highly expressed in clinical melanomas, with low expr
Database Links

HGNC: 46

OMIM: 611785

KEGG: hsa:340273

STRING: 9606.ENSP00000384881

UniGene: Hs.404102

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