Recombinant Human Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1), partial

1. These results suggest that curcumin controls hST8Sia I gene expression via AMPK signal pathway in A549 cells. PMID: 30004453
2. These results from genotype-phenotype analysis might suggest a possible link between the ST8SIA1 functional promoter haplotype and the clinical severity of TAO [thyroid-associated ophthalmopathy]. PMID: 29047240
3. altered expression of miR-33a/let-7e was correlated with ST8SIA1 level, which might contribute to CRC progression PMID: 28751193
4. GD3 and GD3S are highly expressed in glioblastoma multiforme (GBM) stem cell, play a key role in glioblastoma tumorigenicity, and are potential therapeutic targets against GBM. PMID: 27143722
5. Results show that GD3S regulates stem cell function via c-Met and the expression of GD3S is regulated by FOXC2, a transcription factor functioning downstream of several epithelial-mesenchymal transition signaling pathways. PMID: 25109336
6. our study provides support for the GD3-induced cell cycle arrest, disruption of integrin-b1-mediated anchorage, inhibition of angiogenesis and thereby induced apoptosis in pancreatic cancer cells. PMID: 24842107
7. Though results are limited by the small sample size, variants in BDNF and ST8SIA may slow down the early response to antidepressants in subjects non-exposed to stressors at the illness onset, with a remarkable gene-environment interaction PMID: 25163442
8. TNF-alpha and IL-6 secreted from keratinocytes enhanced ST8SIA1 expression in melanocytes. PMID: 24548412
9. This indicates that ST8Sia I is able to act as an oligosialyltransferase in a cellular context. PMID: 22885356
10. Results show that G(D3) synthase expression is sufficient to enhance the tumorigenicity of MDA-MB-231 breast cancer cells through a ganglioside-dependent activation of the c-Met receptor. PMID: 20889649
11. GD3 has a role in hypoxia susceptibility by disabling the c-Src/NF-kappaB survival pathway resulting in lower Mn-SOD expression PMID: 19956670
12. down regulation of GD3 synthase is associated with reduction in GD3 ganglioside expression affecting tumorigenesis and metastasis in F-11 cells. PMID: 11849746
13. Human GD3 synthase gene consisted of five exons and span about 135 kilobases. The 5'-flanking region lacked canonical TATA and CAAT boxes, but contained SP1 binding site(s) as in rat and mouse PMID: 12818424
14. findings suggest that the disialoganglioside(GD3) synthase gene represents a physiological modulator of vascular smooth muscle cell responses that may contribute to plaque instability in atherosclerosis PMID: 15175338
15. has an apoptotic effect on ECV304 cells through downregulation of Bcl-2 expression via dephosphorylation of AKT and CREB PMID: 15196944
16. calnexin controls the biological outcome of GD3 accumulation and reveals a novel role in the stress response PMID: 15319364
17. The cloning and characterization of ST8SIA1 in humans is reported. PMID: 16120058
18. Transcriptional regulation of GD3S expression in Fas-induced Jurkat T-cells shows a critical role of NF-kappa B in regulated expression. PMID: 16481330
19. effects of small interfering (si) RNAs against GD3 synthase gene on the expression of ganglioside GD2 and biological phenotypes of human lung cancer cells expressing GD2. PMID: 16862187
20. These results indicate that NF-kappaB plays an essential role in the transcriptional activity of human GD3 synthase gene essential for GD3 synthesis PMID: 17913261
21. This work advances the hypothesis that GD3 induces a post-translational modification of histone H1 thus influencing the apoptosis process through transcriptional activation/repression of specific genes. PMID: 18261989
22. The functions of four conserved residues between the L and S sialylmotifs in human GD3-synthase were investigated, and it was found that these sites are involved in determining the alpha2,8-linkage specificity of GD3-synthase. PMID: 18348864
23. Two independent studies support an allelic association of multiple sclerosis with polymorphisms in the ST8SIA1 gene. PMID: 18612409
24. Data propose that the recruitment of TG2 into membranes by GD3 might play an important role in the erythroid differentiation in K562 cells. PMID: 18690648
25. Ganglioside GD3-Synthase was associated with poor pathohistological grading in breast cancer PMID: 19125296
26. Isolation and functional characterization of the human glioblastoma-specific promoter region of the human GD3 synthase (hST8Sia1) gene are reported. PMID: 19280063
27. G(D3) synthase overexpression may contribute to increasing the malignant properties of breast cancer cells. PMID: 19335207
28. Variants in ST8SIA1 do not play a major role in susceptibility to multiple sclerosis in Canadian families. PMID: 19428123

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HGNC: 10869

OMIM: 601123

KEGG: hsa:6489

STRING: 9606.ENSP00000379353

UniGene: Hs.408614