Recombinant Human Alpha-tocopherol transfer protein(TTPA)

Code CSB-EP025268HU
Product Type Recombinant Protein
Size US$2466
Uniprot No. P49638
Relevance Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells (PubMed:7887897). Binds both phosphatidylinol 3,4-bisphosphate and phosphatidylinol 4,5-bisphosphate; the resulting conformation change is important for the release of the bound alpha-tocopherol (By similarity).
Image
  • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.

Storage Buffer Tris-based buffer,50% glycerol
Alias Alpha-TTP
Species Homo sapiens (Human)
Purity Greater than 90% as determined by SDS-PAGE.
Sequence MAEARSQPSAGPQLNALPDHSPLLQPGLAALRRRAREAGVPLAPLPLTDSFLLRFLRARDFDLDLAWRLLKNYYKWRAECPEISADLHPRSIIGLLKAGYHGVLRSRDPTGSKVLIYRIAHWDPKVFTAYDVFRVSLITSELIVQEVETQRNGIKAIFDLEGWQFSHAFQITPSVAKKIAAVLTDSFPLKVRGIHLINEPVIFHAVFSMIKPFLTEKIKERIHMHGNNYKQSLLQHFPDILPLEYGGEEFSMEDICQEWTNFIMKSEDYLSSISESIQ
Research Area Signal Transduction
Source E.coli
Gene Names TTPA
Protein Names Recommended name: Alpha-tocopherol transfer protein Short name= Alpha-TTP
Expression Region 1-278aa
Tag Info N-terminal 6xHis-SUMO-tagged
Mol. Weight 47.7kDa
Protein Description Full Length
Storage The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
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Function Binds alpha-tocopherol, enhances its transfer between separate membranes, and stimulates its release from liver cells
Involvement in disease Ataxia with isolated vitamin E deficiency (AVED)
Subcellular Location Cytoplasm
Database Links

HGNC: 12404

OMIM: 277460

KEGG: hsa:7274

STRING: 9606.ENSP00000260116

UniGene: Hs.69049

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