Recombinant Human Aryl hydrocarbon receptor nuclear translocator (ARNT), partial

1. Genetic variation at the 8q24.21 renal cancer susceptibility locus affects HIF1A and HIF1B binding to a MYC enhancer. PMID: 27774982
2. in transcriptionally active heterodimer with AHR, which recognizes the dioxin response element (DRE) in the promoter of downstream genes, right next to the DRE-docking sites is the extensive dimerization surface that is more hydrophobic than other surface areas, indicating that the dimerization interface of the AHR transcription complex is largely dictated by hydrophobic contacts PMID: 28396409
3. Here the authors examined the crystal structures of multi-domain NPAS1-ARNT and NPAS3-ARNT-DNA complexes, discovering each to contain four putative ligand-binding pockets. PMID: 27782878
4. Findings reveal that certain blood cancers rely on ARNT isoform 1 to potentiate proliferation by antagonizing RelB and p53-dependent cell cycle arrest and apoptosis. PMID: 26909609
5. The structure clearly disclosed that AhRR competitively represses AhR binding to ARNT and target DNA and further suggested the existence of an AhRR-ARNT-specific repression mechanism. This study provides a structural basis for understanding the mechanism by which AhRR represses AhR-mediated gene transcription. PMID: 28904176
6. Study showed that polymorphism rs2228099 of the ARNT gene could be a novel susceptibility gene to essential hypertension. PMID: 27977510
7. The results revealed a HIF-1alpha-dependent mechanism leading to ARNT upregulation in hypoxia. PMID: 27362802
8. The protein levels of phosphorylated (p)Akt, Erk1/2, pErk1/2, HIF1alpha and HIF1beta were significantly increased by 5.89, 0.5, 0.59, 1.46 and 0.92fold, respectively, in the patients with PAH, compared with those in the controls group PMID: 27667582
9. this study shows that ARNT is upregulated in skin from atopic dermatitis patients in China PMID: 27129092
10. Authors report here that not only HIF1alpha but also ARNT regulates VEGF expression in 3D cancer spheroids. Results suggest the utility of the in vitro 3D cancer spheroid model for investigating angiogenesis in cancerous tissues. PMID: 27542820
11. The results of this study indicate that ARNT depletion renders tumour cells susceptible to radiation whereas overexpression of this transcription factor confers radioresistance PMID: 26572229
12. HIF-1beta might act as a novel cross-link between the HIF and NF-kappaB pathways in suppression of angiogenesis by LDL, while proteasome inhibitors might promote angiogenesis by reactivating this signaling cascade under hyperlipidemia. PMID: 26388611
13. ARNT Val189Val polymorphism is not associated with endometriosis in Asians. PMID: 26101050
14. HIF1 regulates claudin-1 in intestinal epithelium. This regulation is important for intestinal epithelial tight junction integrity. PMID: 25904334
15. Down-regulation of ARNT promotes colorectal cancer metastasis by activating the fibronectin/integrin beta1/FAK axis. PMID: 25839165
16. AhR/ARNT activation and overexpression of BCL6 are collectively responsible for differential expression of more than 100 genes in diffuse large B-cell lymphoma cell line. PMID: 25769544
17. Data indicate that silencing of hypoxia-inducible factor-1 beta (HIF-1beta) sensitizes tumor cells to hypoxic apoptosis. PMID: 25068796
18. ARNT expression in the placental vasculature mediates key angiogenic expression and fetoplacental endothalial cell angiogenesis, and low ARNT expression in FGRadv ECs appears to be a key factor in deficient angiogenesis. PMID: 25343232
19. findings suggest that TACC3 could be recruited as a bridge to cooperatively mediate between the HIF-2alpha PAS-B.ARNT PAS-B complex, thereby participating more directly in HIF-dependent gene transcription than previously anticipated PMID: 25627682
20. The objective of this review is therefore to highlight and summarize current knowledge regarding the hypoxia-dependent upregulation of ARNT PMID: 24849811
21. Arnt suppressed CXCL8, but did not prevent the p65-activation directly. PMID: 25201625
22. knockdown of ARNT in cancer cells reduced the proliferation rate and the transformation ability of those cells. PMID: 24921657
23. Myeloid ARNT is important for innate immune function and wound healing. PMID: 24990649
24. We demonstrate that Arnt is an interaction partner for Miz-1, and that Arnt has a functional role in the regulation of CDKN2B PMID: 24618291
25. Here we discuss recent findings from our lab and others that define roles of the HIF-VEGF axis in the retina. PMID: 24664708
26. ARNT gene deletion is associated with chronic lymphocytic leukemia. PMID: 24249660
27. These findings highlight the importance of the hypoxia-sensing pathway and HIFs in clinical hematology. PMID: 24371328
28. Understanding the DNA binding-independent functions of ARNT may identify novel therapeutic options for the treatment of a large spectrum of disease states. PMID: 23116263
29. ARNT may modulate reactive oxygen species signaling and drug response in acute myeloid leukemia. PMID: 24220583
30. ARNT was found to be responsible for establishing the drug-resistant properties of cancer cells by upregulation of MDR1. PMID: 23907215
31. results suggest that polymorphism located in the promoter of the AHR gene is associated with a protective effect on vitiligo in Han Chinese populations PMID: 22211302
32. In loco synthesis of these highly potent AhR inducers by Malassezia yeasts could have a significant impact on skin homeostatic mechanisms and disease development. PMID: 23448877
33. results show that ER-beta suppresses HIF-1alpha-mediated transcription via aryl hydrocarbon receptor nuclear translocator (ARNT) downregulation, which may account for the tumour suppressive function of ER-beta PMID: 21435239
34. Among a panel of five different cell lines, in 518A2 cells exposed to hypoxia-mimetic cobalt chloride, HIF-1beta is rapidly elevated on protein level. PMID: 23541582
35. ARNT controls AREG expression and the downstream EGFR-ERK pathway in keratinocytes, at least in part, by modulating HDAC activity. PMID: 22505606
36. Binding of the ERalpha and ARNT1 AF2 domains to exon 21 of the SRC1 isoform SRC1e is essential for estrogen- and dioxin-transcription. PMID: 22328528
37. Ainp1 reduces the interaction between ARNT and HIF-1alpha, suppresses the formation of the HIF-1 gel shift complex, and suppresses the ARNT recruitment to the vegf promoter. PMID: 22306343
38. miR-24 negatively regulates ARNT expression in human liver, affecting the expression of its downstream genes. miR-24 would be one of the factors underlying the mechanisms by which ARNT protein is decreased by reactive oxygen species PMID: 22387692
39. Data show that ARNT is an important regulator of hepatocellular carcinoma (HCC) growth and metastasis and could be a promising prognostic candidate in HCC patients. PMID: 21544813
40. The presence of five unique SNPs at the ARNT locus are shown. PMID: 21828933
41. ARNT may regulate many processes relevant to the biology of age related macular degeneration. PMID: 22183315
42. mutations on ARNT PAS-B modulate coactivator selectivity and target gene induction by HIF in vivo, demonstrating a bifunctional role for transcriptional regulation by PAS domains within bHLH-PAS transcription factors PMID: 21512126
43. NF-kB controls the levels of HIF-1a and HIF-1b genes by direct regulation. PMID: 21298084
44. Cloning and functional analysis of the HIF-1beta promoter identifies a prominent region for interferon (IFN)-gamma-dependent repression. PMID: 21199896
45. These results reveal a novel mechanism by which ARNT acts as a modulator to bridge the c-Jun/Sp1 interaction and plays a role in EGF-mediated gene expression under normoxic conditions. PMID: 20508969
46. Reverse transcriptase-polymerase chain reaction analysis disclosed the existence of a ETV6-ARNT fusion gene in a patient with childhood T lymphoblastic leukemia. PMID: 20804916
47. the expression of miR-101 is also modulated at different physiological conditions, such as androgen stimulation and HIF-1alpha/HIF-1beta induction. PMID: 20478051
48. the expression of ARNT protein is significantly reduced in aryl hydrocarbon receptor interacting protein mutation+ tumors PMID: 19850893
49. SRC-1, NCoA-2, and p/CIP are capable of independently enhancing TCDD-dependent induction of a luciferase reporter gene by the AHR/ARNT dimer PMID: 12024042
50. modification by SUMO-1 chiefly at Lys(245) within the PAS domain of this protein, both in vivo and in vitro PMID: 12354770

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HGNC: 700

OMIM: 126110

KEGG: hsa:405

STRING: 9606.ENSP00000351407

UniGene: Hs.632446