Recombinant Human CD209 antigen(CD209),partial

Code CSB-YP873604HU
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Source Yeast
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Code CSB-EP873604HU
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Source E.coli
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Code CSB-EP873604HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP873604HU
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Source Baculovirus
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Code CSB-MP873604HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names CD209
Uniprot No. Q9NNX6
Alternative Names C type lectin domain family 4 member L; C-type lectin domain family 4 member L; CD 209; CD209; CD209 antigen; CD209 antigen-like protein A; CD209 molecule; CD209_HUMAN; Cd209a; CDSIGN; CIRE; CLEC4L; DC SIGN; DC SIGN1; DC-SIGN; DC-SIGN1; DCSIGN; Dendritic cell specific ICAM 3 grabbing nonintegrin 1; Dendritic cell specific ICAM3 grabbing nonintegrin 1; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; Dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; Dengue fever; protection against; included; Dentritic Cell Specific ICAM3 Grabbing Nonintegrin; HIV GP120 Binding Protein; MGC129965; MGC130443; SIGN-R1; SIGNR5
Species Homo sapiens (Human)
Protein Length Partial
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Function
Pathogen-recognition receptor expressed on the surface of immature dendritic cells (DCs) and involved in initiation of primary immune response. Thought to mediate the endocytosis of pathogens which are subsequently degraded in lysosomal compartments. The receptor returns to the cell membrane surface and the pathogen-derived antigens are presented to resting T-cells via MHC class II proteins to initiate the adaptive immune response.; On DCs it is a high affinity receptor for ICAM2 and ICAM3 by binding to mannose-like carbohydrates. May act as a DC rolling receptor that mediates transendothelial migration of DC presursors from blood to tissues by binding endothelial ICAM2. Seems to regulate DC-induced T-cell proliferation by binding to ICAM3 on T-cells in the immunological synapse formed between DC and T-cells.; (Microbial infection) Acts as an attachment receptor for HIV-1 and HIV-2.; (Microbial infection) Acts as an attachment receptor for Ebolavirus.; (Microbial infection) Acts as an attachment receptor for Cytomegalovirus.; (Microbial infection) Acts as an attachment receptor for HCV.; (Microbial infection) Acts as an attachment receptor for Dengue virus.; (Microbial infection) Acts as an attachment receptor for Measles virus.; (Microbial infection) Acts as an attachment receptor for Herpes simplex virus 1.; (Microbial infection) Acts as an attachment receptor for Influenzavirus A.; (Microbial infection) Acts as an attachment receptor for SARS-CoV.; (Microbial infection) Acts as an attachment receptor for Japanese encephalitis virus.; (Microbial infection) Acts as an attachment receptor for Lassa virus. Acts as an attachment receptor for Marburg virusn.; (Microbial infection) Acts as an attachment receptor for Respiratory syncytial virus.; (Microbial infection) Acts as an attachment receptor for Rift valley fever virus and uukuniemi virus.; (Microbial infection) Acts as an attachment receptor for West-nile virus.; (Microbial infection) Probably recognizes in a calcium-dependent manner high mannose N-linked oligosaccharides in a variety of bacterial pathogen antigens, including Leishmania pifanoi LPG, Lewis-x antigen in Helicobacter pylori LPS, mannose in Klebsiella pneumonae LPS, di-mannose and tri-mannose in Mycobacterium tuberculosis ManLAM and Lewis-x antigen in Schistosoma mansoni SEA. Recognition of M.tuberculosis by dendritic cells occurs partially via this molecule.
Gene References into Functions
  1. Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions PMID: 29671117
  2. These findings indicate that DC-SIGN plays an important role in Japanese encephalitis virus transmission from dendritic cells to T cells and provide insight into how Japanese encephalitis virus exploits the migratory and antigen-presenting capabilities of dendritic cells to gain access to lymph nodes for dissemination and persistence in the host. PMID: 28865053
  3. this study shows that DC-SIGN expression in Hofbauer cells may play an important role in immune tolerance in fetal chorionic villi during the development of preeclampsia PMID: 29049918
  4. The DC-SIGN -336G/A polymorphism significantly affects dengue hemorrhagic fever and dengue fever incidence with the effect more pronounced in certain analyzed patient subgroups (Meta-Analysis). PMID: 29054571
  5. The results suggest that DC-SIGN SNPs rs7252229, rs4804803, and rs735240 may influence nasopharyngeal carcinoma risk in the Chinese population. PMID: 28694559
  6. Polymorphism of CD209 and TLR3 genes in populations of North Eurasia PMID: 29368829
  7. searched for the relationship between single nucleotide polymorphism in the promoter region of the CD209, IL-10, IL-28 and 32 base pair deletion in CCR5 coding region (Delta 32) with the human predisposition to development of various clinical presentations of tick-borne encephalitis PMID: 28894041
  8. These results show that DC-SIGN and TLR-4 interactions regulate inflammatory responses in renal tubular epithelial cells and participate in AKI pathogenesis. PMID: 28898406
  9. 1,25(OH)2D3 suppressed the DCSIGN expression in Mycobacterium tuberculosis infected onocytes/macrophages. PMID: 27449998
  10. Studied the association of CD209 promoter haplotypes with risk of HIV-1 infection in a cohort of Spanish male intravenous drug users (IDU) infected with hepatitis C virus (HCV). PMID: 27539513
  11. Upon gp120 binding to DC-SIGN, cellular NF-kappaB signaling was triggered, leading to the induction of matrix metalloproteinases, which subsequently degraded tight junction proteins and disrupted the blood-retinal barrier integrity. PMID: 27605665
  12. This study showed that N-glycans on the Gc and Gn surface glycoproteins redundantly support Rift Valley Fever Virus infection via DC-SIGN. PMID: 27223297
  13. Ligand-driven triggering of TLR-3, -4, NOD2, and DC-SIGN, despite reducing viral replication, markedly increased the capacity of infected dendritic cells to stimulate HIV-specific cytotoxic T-cells. PMID: 28266028
  14. CD209 polymorphisms could play a role in the susceptibility to Hepatitis C infection as well as interferon treatment response PMID: 27348632
  15. The activation of B cells enhances DC-SIGN expression and promotes susceptibility of B cells to the avian H5N1 infection. PMID: 28688767
  16. Binding of common allergens by DC-SIGN on DCs may initiate allergen sensitization of atopic dermatitis or provoke the relapse of atopic dermatitis PMID: 27554335
  17. These results suggest that DC-SIGN may be an alternative receptor for influenza A(H1N1)pdm09 virus. PMID: 28493491
  18. The results demonstrate that DC-SIGN among the many hGBP expressed by DCs binds to alpha-fucosylated HMGs, and suggest that such interactions may be important in influencing immune responses in the developing infant. PMID: 26976925
  19. DC-SIGNR VNTR and DC-SIGN VNTR, were not associated with the risk of pulmonary tuberculosis in a sample of Iranian population PMID: 27309478
  20. CD209 gene -871A/G is associated with decreased susceptibility to pulmonary tuberculosis (PT) overall; -336A/G polymorphism is associated with increased susceptibility in Asians and -139G/A polymorphism is not associated with susceptibility to PT PMID: 26722430
  21. The high-mannose N-linked glycan at N154 of Japanese encephalitis virus E glycoprotein was shown to be crucial for binding to DC-SIGN and subsequent internalization. PMID: 26629951
  22. Preliminary study suggests that OAS gene cluster and CD209 gene polymorphisms influence the risk of developing clinical symptoms in Chikungunya virus-infected patients. PMID: 26398832
  23. DC-SIGN can promote the maturation and activation of dendritic cells on recognition of hepatitis B virus, but wild type virus can escape recognition by DC-SIGN to a certain extent with the help of demannosylated modification. PMID: 26133046
  24. Colorectal mucus can bind the C-type lectin DC-SIGN and block HIV-1 trans-infection of both CCR5 and CXCR4 using HIV-1 strains. PMID: 25793526
  25. Engagement of sIg in FL cells or normal B cells by anti-Ig led to endocytosis in vitro as expected, but DC-SIGN, even when cross-linked, did not lead to significant endocytosis of sIg PMID: 26194765
  26. M2 macrophages induced a DC-SIGN-dependent adhesion of highly mannosylated IgM(+) FL B cells and triggered BCR-associated kinase activation. PMID: 26272216
  27. selective engagement of dendritic cell-SIGN resulting in intracellular persistence in myeloid dendritic cells; however TLR2 activation can overcome autophagy evasion and pathogen persistence in dendritic cells PMID: 25679217
  28. High-resolution crystal structures of the SIGN-R1 carbohydrate recognition domain show 2 binding sites allowing SIGNR1 to simultaneously bind both immune glycoproteins and microbial polysaccharide components. PMID: 25450767
  29. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics. PMID: 26106150
  30. DC-SIGN directs adaptive T helper cell type-2immunity to fucose-expressing pathogens via an IKKepsilon-CYLD-dependent signalling pathway leading to Bcl3 activation. PMID: 24867235
  31. Intestinal enterocytes regulate tissue-associated immune compartments under the control of DC-SIGN in inflammatory bowel disease. PMID: 25574091
  32. Two SNPs of DC-SIGN (rs735239 and rs735240) were associated with susceptibility to fungal keratitis in the northern Han Chinese population. PMID: 25883525
  33. annexin A2 (ANXA2) on nasopharygeal carcinoma cells is a ligand for DC-SIGN on dendritic cells PMID: 25402728
  34. Our results suggest that SNPs in DC-SIGN promoter region can be associated to protection for T1DM in the Northeast Brazilian population. PMID: 25092567
  35. The G allele of rs4804803 is associated with symptomatic dengue (OR 2.3, p=0.08), after accounting for other biological factors including history of infection. PMID: 24911936
  36. CD209 polymorphisms were responsible for the susceptibility of KD, but not CAL formation and IVIG treatment responsiveness. PMID: 25148534
  37. Human herpesvirus 8 gB has a high mannose carbohydrate structure and binds to host DC-SIGN in a dose-dependent manner. PMID: 25018023
  38. Studied the possible association between CD209 rs4804803 (-336 A/G) gene polymorphism and pulmonary tuberculosis (PTB) in a sample of Iranian population. PMID: 23751770
  39. Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population. PMID: 24594345
  40. data shows that immature DENV can infect imDCs through interaction with DC-SIGN, suggesting that immature and partially immature DENV particles may contribute to dengue pathogenesis during primary infection PMID: 24886790
  41. These findings indicate that the G allele of CD209 promoter region downregulates the spectrum of symptoms during the early acute phase of dengue fever, putatively decreasing the viremia, as suggested in the literature. PMID: 24797508
  42. Titration of the monomeric DC-SIGN CRD with Le(X) monitored by 2D NMR revealed significant perturbations of DC-SIGN cross-peak positions in (1)H-(15)N heteronuclear single quantum coherence (HSQC) spectra and identified residues near the binding site. PMID: 25121780
  43. Data indicate that the expression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) decreases and that of toll-like receptor 2 (TLR2) protein increases in patients with chronic urticaria (CU). PMID: 25001940
  44. Monocyte-derived dendritic cells could bind efficiently enterovirus 71 viruses through viral binding to DC-SIGN molecule, and these captured-viruses could be transferred to susceptible cells for robust infection. PMID: 24620896
  45. These data demonstrate a new role for myelin glycosylation in the control of immune homeostasis in the healthy human brain through the MOG-DC-SIGN homeostatic regulatory axis, which is comprised by inflammatory insults that affect glycosylation. PMID: 24935259
  46. upregulated on dendritic cells in leprosy to induce production of IL-10 PMID: 23816300
  47. DC-SIGN-mediated virus entry is clathrin dependent. PMID: 23840690
  48. The results suggest that rs2287886 G/G genotype of CD209 gene is associated with development of dengue requiring hospitalization while A/A genotype of rs735239 is associated with thrombocytopenia in dengue cases. PMID: 23624202
  49. DC-SIGN has a role in lectin-EGF antibody promotion of regulatory T cells and attenuation of nephrotoxic nephritis PMID: 23627732
  50. These data reveal that DC-SIGN can facilitate cell entry of Lassa virus in human monocyte-derived immature dendritic cells but that its role seems distinct from the function as an authentic entry receptor reported for phleboviruses. PMID: 23966408

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Subcellular Location [Isoform 1]: Cell membrane; Single-pass type II membrane protein.; [Isoform 2]: Cell membrane; Single-pass type II membrane protein.; [Isoform 3]: Cell membrane; Single-pass type II membrane protein.; [Isoform 4]: Cell membrane; Single-pass type II membrane protein.; [Isoform 5]: Cell membrane; Single-pass type II membrane protein.; [Isoform 6]: Secreted.; [Isoform 7]: Secreted.; [Isoform 8]: Secreted.; [Isoform 9]: Secreted.; [Isoform 10]: Secreted.; [Isoform 11]: Secreted.; [Isoform 12]: Secreted.
Tissue Specificity Predominantly expressed in dendritic cells and in DC-residing tissues. Also found in placental macrophages, endothelial cells of placental vascular channels, peripheral blood mononuclear cells, and THP-1 monocytes.
Database Links

HGNC: 1641

OMIM: 604672

KEGG: hsa:30835

STRING: 9606.ENSP00000315477

UniGene: Hs.278694

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