CD209 Antibody

1. Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions PMID: 29671117
2. These findings indicate that DC-SIGN plays an important role in Japanese encephalitis virus transmission from dendritic cells to T cells and provide insight into how Japanese encephalitis virus exploits the migratory and antigen-presenting capabilities of dendritic cells to gain access to lymph nodes for dissemination and persistence in the host. PMID: 28865053
3. this study shows that DC-SIGN expression in Hofbauer cells may play an important role in immune tolerance in fetal chorionic villi during the development of preeclampsia PMID: 29049918
4. The DC-SIGN -336G/A polymorphism significantly affects dengue hemorrhagic fever and dengue fever incidence with the effect more pronounced in certain analyzed patient subgroups (Meta-Analysis). PMID: 29054571
5. The results suggest that DC-SIGN SNPs rs7252229, rs4804803, and rs735240 may influence nasopharyngeal carcinoma risk in the Chinese population. PMID: 28694559
6. Polymorphism of CD209 and TLR3 genes in populations of North Eurasia PMID: 29368829
7. searched for the relationship between single nucleotide polymorphism in the promoter region of the CD209, IL-10, IL-28 and 32 base pair deletion in CCR5 coding region (Delta 32) with the human predisposition to development of various clinical presentations of tick-borne encephalitis PMID: 28894041
8. These results show that DC-SIGN and TLR-4 interactions regulate inflammatory responses in renal tubular epithelial cells and participate in AKI pathogenesis. PMID: 28898406
9. 1,25(OH)2D3 suppressed the DCSIGN expression in Mycobacterium tuberculosis infected onocytes/macrophages. PMID: 27449998
10. Studied the association of CD209 promoter haplotypes with risk of HIV-1 infection in a cohort of Spanish male intravenous drug users (IDU) infected with hepatitis C virus (HCV). PMID: 27539513
11. Upon gp120 binding to DC-SIGN, cellular NF-kappaB signaling was triggered, leading to the induction of matrix metalloproteinases, which subsequently degraded tight junction proteins and disrupted the blood-retinal barrier integrity. PMID: 27605665
12. This study showed that N-glycans on the Gc and Gn surface glycoproteins redundantly support Rift Valley Fever Virus infection via DC-SIGN. PMID: 27223297
13. Ligand-driven triggering of TLR-3, -4, NOD2, and DC-SIGN, despite reducing viral replication, markedly increased the capacity of infected dendritic cells to stimulate HIV-specific cytotoxic T-cells. PMID: 28266028
14. CD209 polymorphisms could play a role in the susceptibility to Hepatitis C infection as well as interferon treatment response PMID: 27348632
15. The activation of B cells enhances DC-SIGN expression and promotes susceptibility of B cells to the avian H5N1 infection. PMID: 28688767
16. Binding of common allergens by DC-SIGN on DCs may initiate allergen sensitization of atopic dermatitis or provoke the relapse of atopic dermatitis PMID: 27554335
17. These results suggest that DC-SIGN may be an alternative receptor for influenza A(H1N1)pdm09 virus. PMID: 28493491
18. The results demonstrate that DC-SIGN among the many hGBP expressed by DCs binds to alpha-fucosylated HMGs, and suggest that such interactions may be important in influencing immune responses in the developing infant. PMID: 26976925
19. DC-SIGNR VNTR and DC-SIGN VNTR, were not associated with the risk of pulmonary tuberculosis in a sample of Iranian population PMID: 27309478
20. CD209 gene -871A/G is associated with decreased susceptibility to pulmonary tuberculosis (PT) overall; -336A/G polymorphism is associated with increased susceptibility in Asians and -139G/A polymorphism is not associated with susceptibility to PT PMID: 26722430
21. The high-mannose N-linked glycan at N154 of Japanese encephalitis virus E glycoprotein was shown to be crucial for binding to DC-SIGN and subsequent internalization. PMID: 26629951
22. Preliminary study suggests that OAS gene cluster and CD209 gene polymorphisms influence the risk of developing clinical symptoms in Chikungunya virus-infected patients. PMID: 26398832
23. DC-SIGN can promote the maturation and activation of dendritic cells on recognition of hepatitis B virus, but wild type virus can escape recognition by DC-SIGN to a certain extent with the help of demannosylated modification. PMID: 26133046
24. Colorectal mucus can bind the C-type lectin DC-SIGN and block HIV-1 trans-infection of both CCR5 and CXCR4 using HIV-1 strains. PMID: 25793526
25. Engagement of sIg in FL cells or normal B cells by anti-Ig led to endocytosis in vitro as expected, but DC-SIGN, even when cross-linked, did not lead to significant endocytosis of sIg PMID: 26194765
26. M2 macrophages induced a DC-SIGN-dependent adhesion of highly mannosylated IgM(+) FL B cells and triggered BCR-associated kinase activation. PMID: 26272216
27. selective engagement of dendritic cell-SIGN resulting in intracellular persistence in myeloid dendritic cells; however TLR2 activation can overcome autophagy evasion and pathogen persistence in dendritic cells PMID: 25679217
28. High-resolution crystal structures of the SIGN-R1 carbohydrate recognition domain show 2 binding sites allowing SIGNR1 to simultaneously bind both immune glycoproteins and microbial polysaccharide components. PMID: 25450767
29. Data suggest that serum amyloid P (SAP) activates CD209 DC-SIGN to regulate the innate immune system differently from C-reactive protein (CRP), and that DC-SIGN is a target for antifibrotics. PMID: 26106150
30. DC-SIGN directs adaptive T helper cell type-2immunity to fucose-expressing pathogens via an IKKepsilon-CYLD-dependent signalling pathway leading to Bcl3 activation. PMID: 24867235
31. Intestinal enterocytes regulate tissue-associated immune compartments under the control of DC-SIGN in inflammatory bowel disease. PMID: 25574091
32. Two SNPs of DC-SIGN (rs735239 and rs735240) were associated with susceptibility to fungal keratitis in the northern Han Chinese population. PMID: 25883525
33. annexin A2 (ANXA2) on nasopharygeal carcinoma cells is a ligand for DC-SIGN on dendritic cells PMID: 25402728
34. Our results suggest that SNPs in DC-SIGN promoter region can be associated to protection for T1DM in the Northeast Brazilian population. PMID: 25092567
35. The G allele of rs4804803 is associated with symptomatic dengue (OR 2.3, p=0.08), after accounting for other biological factors including history of infection. PMID: 24911936
36. CD209 polymorphisms were responsible for the susceptibility of KD, but not CAL formation and IVIG treatment responsiveness. PMID: 25148534
37. Human herpesvirus 8 gB has a high mannose carbohydrate structure and binds to host DC-SIGN in a dose-dependent manner. PMID: 25018023
38. Studied the possible association between CD209 rs4804803 (-336 A/G) gene polymorphism and pulmonary tuberculosis (PTB) in a sample of Iranian population. PMID: 23751770
39. Data obtained suggest that the OAS2 rs1293762 and CD209 rs2287886 SNPs are associated with predisposition to chronic hepatitis C in Russian population. PMID: 24594345
40. data shows that immature DENV can infect imDCs through interaction with DC-SIGN, suggesting that immature and partially immature DENV particles may contribute to dengue pathogenesis during primary infection PMID: 24886790
41. These findings indicate that the G allele of CD209 promoter region downregulates the spectrum of symptoms during the early acute phase of dengue fever, putatively decreasing the viremia, as suggested in the literature. PMID: 24797508
42. Titration of the monomeric DC-SIGN CRD with Le(X) monitored by 2D NMR revealed significant perturbations of DC-SIGN cross-peak positions in (1)H-(15)N heteronuclear single quantum coherence (HSQC) spectra and identified residues near the binding site. PMID: 25121780
43. Data indicate that the expression of dendritic cell-specific intercellular adhesion molecule-3-grabbing nonintegrin (DC-SIGN) decreases and that of toll-like receptor 2 (TLR2) protein increases in patients with chronic urticaria (CU). PMID: 25001940
44. Monocyte-derived dendritic cells could bind efficiently enterovirus 71 viruses through viral binding to DC-SIGN molecule, and these captured-viruses could be transferred to susceptible cells for robust infection. PMID: 24620896
45. These data demonstrate a new role for myelin glycosylation in the control of immune homeostasis in the healthy human brain through the MOG-DC-SIGN homeostatic regulatory axis, which is comprised by inflammatory insults that affect glycosylation. PMID: 24935259
46. upregulated on dendritic cells in leprosy to induce production of IL-10 PMID: 23816300
47. DC-SIGN-mediated virus entry is clathrin dependent. PMID: 23840690
48. The results suggest that rs2287886 G/G genotype of CD209 gene is associated with development of dengue requiring hospitalization while A/A genotype of rs735239 is associated with thrombocytopenia in dengue cases. PMID: 23624202
49. DC-SIGN has a role in lectin-EGF antibody promotion of regulatory T cells and attenuation of nephrotoxic nephritis PMID: 23627732
50. These data reveal that DC-SIGN can facilitate cell entry of Lassa virus in human monocyte-derived immature dendritic cells but that its role seems distinct from the function as an authentic entry receptor reported for phleboviruses. PMID: 23966408

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HGNC: 1641

OMIM: 604672

KEGG: hsa:30835

STRING: 9606.ENSP00000315477

UniGene: Hs.278694