Recombinant Human Chromosome transmission fidelity protein 8 homolog isoform 2 (CHTF8)

Code CSB-YP005419HU
MSDS
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Source Yeast
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Code CSB-EP005419HU
MSDS
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Source E.coli
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Code CSB-EP005419HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP005419HU
MSDS
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Source Baculovirus
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Code CSB-MP005419HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
CHTF8
Uniprot No.
Alternative Names
DERPCDecreased expression in renal and prostate cancer protein
Species
Homo sapiens (Human)
Expression Region
1-524
Target Protein Sequence
MKEPRIFPRE RPTPWTRAPL PPRGRLDGSL GPQGGPVLNT GHPLGVNSDP FLMAAGSLGG NLTPFPRNPS PFPASSGSLA SNPAPFPAGA RDPSMASFPR GMNPTGTGAV SFPRPGGLLG PGPGPGPTLN PRTGALPGPG PLSNPRLGGL PGPGPMSNPR AGGLLGAGPD PRGGGPMGPG SGPNLRAGVL LTSGNGPPNP RPVGLGPGPN PNLRSGFLGT NPAPRSGVFP GPGLGPNPRP SGLGPGPNLD ARAGGLLGTG SGLNLRMAGP QGLDLAPILR AAGLLGANSA SFSQASGNMG TSPSSMARVP GPMGPNSGPS SRGIGLPGPN PSPMSRAPGP IGPNSAHFSR PVGPMGVNAN PFPRGAGSSA FSQSSGTLAS NPATFQRSAG LQGSNPTIFP RASGPLGPNP ANFPRATGLQ GPSPTTFPRS TGPLGPGQVT FPRPAAGHLG PSPAGPVGIN PAPFTRPTGT LGLNPASFPR MNGPAGKSFV PFPRVGSLPG TNPAAFPRPG GPMAAMYPNG MLPP
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Potential tumor suppressor. Inhibits prostate tumor cell growth, when overexpressed.
Gene References into Functions
  1. Stable interaction between the human proliferating cell nuclear antigen loader complex Ctf18-replication factor C (RFC) and DNA polymerase {epsilon} is mediated by the cohesion-specific subunits, Ctf18, Dcc1, and Ctf8. PMID: 20826785
  2. hCTF18, hCTF8, and hDCC1 interact with each other as well as with the p38 subunit of RFC PMID: 12766176
  3. The alternative Ctf18-Dcc1-Ctf8-replication factor C complex required for sister chromatid cohesion loads proliferating cell nuclear antigen onto DNA. PMID: 12930902
Subcellular Location
Nucleus.
Protein Families
DERPC family
Tissue Specificity
Ubiquitously expressed, with abundant expression in kidney, skeletal muscle, testis, liver, ovary, and heart and moderate expression in prostate. Expression is significantly reduced in renal and prostate tumors. No differential expression in breast cancer
Database Links

HGNC: 24353

OMIM: 613202

UniGene: Hs.85962

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