Recombinant Human DNA replication licensing factor MCM4 (MCM4), partial

1. MCM4 and MCM7 expression is significantly correlated with Ki-67, Bmi1, and cyclin E expression in esophageal adenocarcinoma, squamous cell carcinoma and precancerous lesions. PMID: 27476776
2. This MCM4 mutation affected human MCM4/6/7 complex formation, since the complex containing the mutant MCM4 protein is unstable and the mutant MCM4 protein is tend to be degraded. PMID: 27794528
3. We did not find any evidence of augmented response to a short-term (48 h) cisplatin treatment in these MCM4-deficient cells. However, MCM4-/HPV16+ SiHa cells cannot withstand a prolonged treatment (up to 5 days) of even a sublethal dosage of cisplatin PMID: 26188903
4. Purified MCM4/6/7 complex containing the G364R MCM4 exhibited similar levels of single-stranded DNA binding and ATPase activities to the complex containing wild-type MCM4 PMID: 25661590
5. Mutant p53 depletion profoundly influenced PARP1 localization and increased the level of PCNA and MCM4 proteins. PMID: 25733866
6. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta) protein attenuates vascular lesion formation by inhibition of chromatin loading of minichromosome maintenance complex in smooth muscle cells PMID: 23264620
7. point mutation of MCM4 perturbs proper interaction with MCM6 to affect complex formation of MCM4/6/7 that is a core structure of MCM2-7 complex PMID: 22668557
8. Mutations in MCM4/PRKDC represent a novel cause of DNA breakage and NK cell deficiency. PMID: 22499342
9. Widdrol breaks DNA directly in HT29 cells, resulting in checkpoint activation via Chk2-p53-Cdc25A-p21-MCM4 pathway and finally cells go to G1-phase cell cycle arrest and apoptosis. PMID: 22160829
10. partial MCM4 deficiency results in a genetic syndrome of growth retardation with adrenal insufficiency and selective NK deficiency PMID: 22354167
11. MCM4 mutation may have a role in adrenal failure, short stature, and natural killer cell deficiency PMID: 22354170
12. higher expression in non-small cell lung cancer PMID: 20884074
13. MCM4 did not predict patient survival in this series of cutaneous melanomas. PMID: 20398247
14. the phosphorylation of MCM4 in the checkpoint control inhibits DNA replication, which includes blockage of DNA fork progression, through inactivation of the MCM complex PMID: 12714602
15. HU- or UV irradiation-stimulated phosphorylation of MCM4 at several CDK sites led to inhibition of MCM4 helicase activity, consistent with the notion that the phosphorylation of MCM4 is involved in regulation of DNA synthesis in the checkpoint control. PMID: 15037254
16. These results suggest that phosphorylation of MCM4 has several distinct and site-specific roles in the function of MCM during the mammalian cell cycle. PMID: 16519687
17. Expression of EBV-protein kinase caused phosphorylation of Thr-19 & Thr-110 on MCM4 PMID: 17005684
18. MCM4 phosphorylation by Cdc7 kinase facilitates its interaction with Cdc45 on chromatin PMID: 17046832
19. The positive rate of MCM4 was significantly higher in stage T3 than in stage T1 esophageal cancer. PMID: 17222376
20. Data show that two fragments (148-441 and 442-676) from the central region of MCM2 were mainly responsible for the interaction between MCM2 and MCM4, and this was revealed by a pulldown analysis using MCM4 protein beads. PMID: 18190532
21. Sequence alignment of archaeal MCMs and MCM4 from Homo sapiens and Saccharomyces cerevisiae shows that Aeropyrum pernix MCM shares 32% identity with human and yeast MCM4. PMID: 19053250

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HGNC: 6947

OMIM: 602638

KEGG: hsa:4173

STRING: 9606.ENSP00000262105

UniGene: Hs.460184