Recombinant Human DNA topoisomerase 2-binding protein 1 (TOPBP1), partial

1. The cells expressing an ATR-activation domain mutant of TopBP1 show increased initiation of DNA replication in the S phase by losing local dormant origin suppression. PMID: 30104465
2. these data uncover two distinct mechanisms by which mutp53 enhances DNA replication: (i) Both contact and conformational mutp53s can bind TopBP1 and attenuate the checkpoint response to replication stress, and (ii) during normal growth, contact (but not conformational) mutp53s can override the Cdk2 requirement to promote replication by facilitating the TopBP1/Treslin interaction. PMID: 28439015
3. The rs115160714 TopBP1 may be a genetic marker of etiology and progression in laryngeal cancer. PMID: 26503213
4. The innate immune regulator STAT-5 is shown to regulate transcription of the ATR binding factor TopBP1, and this is critical for the induction of the ATR pathway in human papillomavirus-infected keratinocytes. PMID: 26695634
5. TOPBP1 physically binds PLK1 and promotes PLK1 kinase-mediated phosphorylation of RAD51 at serine 14, a modification required for RAD51 recruitment to chromatin. PMID: 26811421
6. Functional analyses indicat that the expression TopBP1 and Claspin positively affects the survival of brain cancer cells after exposure to radiation. PMID: 25216549
7. TopBP1 interacts with BLM to maintain genome stability but is dispensable for preventing BLM degradation.Crucial residues mediating TopBP1-MDC1 interactions identified. PMID: 25794620
8. TopBP1 maintains genome integrity in mitosis by controlling chromatin recruitment of SLX4 and by facilitating unscheduled DNA synthesis. PMID: 26283799
9. Findings demonstrate that TopBP1 and ATR are able to inhibit the synthesis of rRNA and to activate nucleolar stress pathway. PMID: 25916852
10. TOPBP1 has a role in recruiting TOP2A to ultra-fine anaphase bridges to aid in their resolution PMID: 25762097
11. The results suggest that interactions between TopBP1 and E2 and between Brd4 and E2 are required to correctly initiate human papillomavirus 16 DNA replication but are not required for continuing DNA replication. PMID: 25694599
12. Phosphorylation of BRIT1 protein coordinates TopBP1 protein recruitment and amplifies ATR signaling in cell DNA damage. PMID: 25301947
13. High TopBP1 mRNA and protein expression is associated with endometrial cancer. PMID: 24346708
14. Studies identify the SIRT1-TopBP1 axis as a key signaling mode in the regulation of the metabolic checkpoint and the DNA damage checkpoint. PMID: 25454945
15. TopBP1 deficiency may increase susceptibility to small vessel loss in IPAH. PMID: 24702692
16. BLM was ubiquitinated by E3 ligase MIB1 and degraded in G1 cells but was stabilized by TopBP1 in S phase cells. PMID: 24239288
17. Different modes of phosphopeptide binding by TOPBP1 BRCT domains in the DNA damage response. PMID: 23891287
18. Akt can switch the TopBP1 function from checkpoint activation to transcriptional regulation by regulating its quaternary structure. PMID: 24081328
19. Polymorphism in TOPBP1 gene is associated with pancreatic cancer. PMID: 23908141
20. our results showed that rs115160714 polymorphism can increase breast cancer risk and is associated with changes in TopBP1 expression. PMID: 23277395
21. amino acid residues 741-885 are necessary for oligomerization of TopBP1 for centrosomal localization PMID: 23685152
22. Recent findings suggest TopBP1 to be a breast and ovarian cancer susceptibility gene.[review] PMID: 23819404
23. Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance. PMID: 23383325
24. the affinity of Rad9 to TopBP1 correlates with the activation of the cellular DNA damage response and survival after DNA damage in HeLa cells. PMID: 22925454
25. An interaction between human papillomavirus 16 E2 and TopBP1 is required for optimum viral DNA replication and episomal genome establishment PMID: 22973044
26. data suggest that decreased level of TopBP1 mRNA and increased level of TopBP1 protein might be associated with progression of hereditary breast cancer PMID: 22544570
27. Localisation of TopBP1 at DNA damage sites was noticed as early as 5 s following damage induction, whereas p54(nrb) and PSF localised there after 20 s. PMID: 22213094
28. TopBP1 is likely to be involved in hereditary predisposition to breast and/or ovarian cancer PMID: 22708334
29. findings show TopBP1 interacts with p53 hot spot mutants and NF-YA and promotes mutant p53 and p300 recruitment to NF-Y target gene promoters; TopBP1 mediates mutant p53 gain of function in cancer PMID: 21930790
30. Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1). PMID: 21502314
31. The specific TopBP1-MDC1 interaction was mediated by the fifth BRCT domain of TopBP1 and the Ser-Asp-Thr repeats of MDC1. TopBP1 accumulation at stalled replication forks was promoted by the H2AX/MDC1 signaling cascade. PMID: 21482717
32. These results suggest that the localization of TopBP1 to the mitotic centrosomes is necessary for proper mitotic progression. PMID: 21291884
33. TopBP1 deficiency in untransformed mouse and human primary cells induces cellular senescence rather than apoptosis. These results indicate that TopBP1 is essential for cell proliferation and maintenance of chromosomal integrity. PMID: 21149450
34. Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control. PMID: 21127055
35. There is no evidence for the TOPBP1*Arg309Cys variant to confer an increased risk for breast cancer in the German population. PMID: 21108795
36. the crystal structure of the N-terminal region of human TopBP1, reveals an unexpected triple-BRCT domain structure. PMID: 20724438
37. the crystal structure of the TopBP1N-terminal region (residues 1-290) at 2.4A resolution was reported. PMID: 20858457
38. The phosphorylation at both serine residues occurs in vivo and is required for the efficient interaction with TopBP1 in vitro. PMID: 20545769
39. Data provide insights into how Ad modulates ATR signaling pathways by promoting TOPBP1 degradation during infection. PMID: 20566845
40. The interaction between TopBP1 and BACH1 is required for the extension of single-stranded DNA regions and RPA loading following replication stress, which is a prerequisite for the subsequent activation of replication checkpoint. PMID: 20159562
41. proliferating cell nuclear antigen, ATR, TopBP1, and Chk1 are recruited to chromatin in a MutLalpha- and MutSalpha-dependent fashion after N-methyl-N'-nitro-N-nitrosoguanidine treatment. PMID: 20029092
42. interaction between the human papillomavirus 16 transcription/replication factor E2 and the DNA damage response protein TopBP1 PMID: 11934899
43. TopBP1 is regulated by PML by association and stabilization of the protein in response to IR-induced DNA damage PMID: 12773567
44. Both TopBP1 and BRCA1 specifically regulate the G(2)-M checkpoint, partially compensating each function. PMID: 12810625
45. hRad9/hHus1/hRad1 complex acts as a checkpoint sensor during S phase by rapidly localizing to sites of DNA damage and transducing checkpoint responses by facilitating proper localization of downstream checkpoint proteins, including TopBP1. PMID: 12941802
46. transcription of human MCM10 and TopBP1 is activated by transcription factors E2F1-3, but not by factors E2F4-7 PMID: 15195143
47. TopBP1 is a c-Abl-interacting protein and a repressor for c-Abl expression PMID: 15961388
48. TopBP1 plays a critical role in the maintenance of genomic stability during normal S phase as well as following genotoxic stress. PMID: 16314514
49. Data show that recombinant TopBP1 induces a large increase in the kinase activity of both Xenopus and human ATR-ATRIP. PMID: 16530042
50. Cooperative regulation of the TopBP1 promoter by Egr-1 and E2F. PMID: 16831524

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HGNC: 17008

OMIM: 607760

KEGG: hsa:11073

STRING: 9606.ENSP00000260810

UniGene: Hs.593379