Recombinant Human Histone-arginine methyltransferase CARM1 (CARM1)

1. N-terminal EVH1 domain of CARM1 is necessary and sufficient for substrate recognition and is required for methylation of most CARM1 substrates. PMID: 28537268
2. SKP2 promotes HCC progression and its nuclear functions of autophagy induction with CARM1 and AMPK, which may provide a potential target for HCC therapy. PMID: 29991055
3. The Overexpression of CARM1 Promotes Human Osteosarcoma Cell Proliferation through the pGSK3beta/beta-Catenin/cyclinD1 Signaling Pathway PMID: 28924379
4. The CARM1-PKM2 axis serves as a metabolic reprogramming mechanism in tumorigenesis. PMID: 29058718
5. Arginine (di)methylated human leukocyte antigen class I peptides, which are asymmetrically dimethylated, most likely by CARM1, are favorably presented by HLA-B*07. PMID: 27503676
6. Estrogen receptor recruits steroid receptor coactivator-3 primary coactivator and secondary coactivators, p300/CBP and CARM1 to regulate genetic transcription. PMID: 28844863
7. Arginine methylation of MDH1 by CARM1 regulates cellular redox homeostasis and suppresses glutamine metabolism of pancreatic cancer. PMID: 27840030
8. Here, the crystal structures of human CARM1 with the S-adenosylmethione (SAM) mimic sinefungin and three different peptide sequences from histone H3 and PABP1 are presented, with both nonmethylated and singly methylated arginine residues exemplified. PMID: 26551522
9. CARM1 associates with major nonsense-mediated mRNA decay factor UPF1 and promotes its occupancy on premature terminating codon-containing transcripts in spinal muscular atrophy. PMID: 26656492
10. Monitoring of the CARM1-dependent production of monomethylated and dimethylated peptides over time by self-assembled monolayer and matrix-assisted laser desorption ionization mass spectrometry revealed that methylation by CARM1 is distributive. PMID: 26848779
11. no obvious association of CARM1 isoform expression and clinical correlates in breast cancer PMID: 26030442
12. disruption of CARM1 enhances the nuclear retention of mRNAs containing IRAlus PMID: 25792598
13. Data indicate that coactivator-associated arginine methyltransferase 1 (CARM1) regulates neural differentiation through Nanog homeobox protein and microRNA miR92a. PMID: 25392304
14. Like insulin, CARM1 overexpression increased CDK2 and CDK4 expression. In addition, CARM1 knockdown reduced the number of insulin-induced G2/M phase cells PMID: 25934150
15. a noncoding variant in the CARM1-promoter functions as a regulator of gene transcription and homocysteine levels PMID: 25064859
16. O-GlcNAcylation of CARM1 at its C-terminus is an important determinant for CARM1 substrate specificity. PMID: 25585345
17. PRMT4 has a role in arginine methylation, which negatively regulates retinoblastoma tumor suppressor protein and promotes E2F-1 dissociation PMID: 25348716
18. PBMCs from patients with ACS showed higher levels of CARM1 mRNA and protein expression.CARM1 regulated the transcription of IP-10, IL-8, and MCP-1. miR-15a modulated CARM1 expression through targeted binding to CARM1 3'-UTR. PMID: 24530761
19. high-glucose-induced CARM1 expression increases RPE cell apoptosis via H3R17 asymmetric dimethylation PMID: 25072916
20. CARM1 and PRMT1 are dysregulated in lung cancer; only CARM1 expression was found to be correlated with tumor differentiation and neither CARM1 nor PRMT1 expression was correlated with survival. PMID: 24211191
21. Overexpression of PRMT4 represses miR-223 via methylation of RUNX1 and blocks myeloid differentiation. PMID: 24332853
22. CARM1 overexpression was associated with poorly characterized clinicopathologic parameters and HER2 overexpression in invasive breast cancer. PMID: 23915145
23. we identify BAF155 as a substrate for arginine methyltransferase CARM1. PMID: 24434208
24. increased cytoplasmic CARM1, relative to nuclear levels, appear to be associated with self-identified African ethnicity and this result is being further investigated using quantified genetic ancestry measures. PMID: 23663560
25. CARM1 could be a potential marker of luminal class subclassification and for target therapy, particularly in the ER-positive luminal-like subgroup. PMID: 23887673
26. Arginine 42 of histone H3 (H3R42), is dimethylated by the methyltransferases coactivator arginine methyltransferase 1 (CARM1) and protein arginine methyltransferase 6 (PRMT6) in vitro and in vivo. PMID: 23980157
27. Data show the transcriptional regulation of the human ferritin gene by coordinated regulation of Nrf2 and protein arginine methyltransferases PRMT1 and PRMT4. PMID: 23699174
28. CARM1 represses replicative senescence by methylating HuR. PMID: 23837869
29. Inhibition of CARM1 decreases PELP1 oncogenic activity. PMID: 23486015
30. the miR-181c-CARM1 pathway has an important role in regulating the differentiation of human embryonic stem cells PMID: 23301034
31. These findings reveal an important and so far unknown connection between PRMT4 and the chromatin remodeller Mi2 in c-Myb signalling. PMID: 23505388
32. Findings indicate that expression of PRMT4/CARM1 and PRMT6 is deregulated in melanoma. PMID: 23265702
33. found that CARM1 facilitates Sox2-mediated transactivation and directly methylates Sox2 at arginine 113 PMID: 22046437
34. Signal transduction in cell death and survival involves a role for CARM1 in arginine methylation. PMID: 21445011
35. A coactivator role of CARM1 in the dysregulation of beta-catenin activity in colorectal cancer cell growth and gene expression PMID: 21478268
36. Findings suggest that coexpression of CARM1 and ERalpha may provide a better biomarker of well-differentiated breast cancer. PMID: 21282336
37. CARM1 was particularly overexpressed in colorectal cancers while CARM1 expression was not prevalent in prostate and breast cancers. PMID: 20462455
38. The physical interaction of CARM1 and PCAF is likely pivotal for the activation of PCAF in the downstream of CARM1 pathway for inducing myogenin under Tetradecanoylphorbol Acetate -induced differentiation. PMID: 20213728
39. phosphorylation of CARM1 by PKA at a single serine is necessary and sufficient for direct binding to the unliganded hormone-binding domain of ERalpha, and the interaction is necessary for cAMP activation of ERalpha PMID: 20360387
40. Methylates PAB1 and TARPP, suggesting a role in regulating transcription/translation. PMID: 11850402
41. The CBP/p300 acetylase and the CARM1 methyltransferase can positively regulate the expression of estrogen-responsive genes, there is a crosstalk between lysine acetylation and arginine methylation on chromatin PMID: 12498683
42. CARM1 plays a significant role in promoting the differentiation of early thymocyte progenitors, possibly through its direct action on TARPP. PMID: 15096520
43. overexpression of CARM1 is involved in the development of prostate carcinoma PMID: 15221992
44. results show that CARM1/PRMT4 is a novel transcriptional coactivator of NF-kappaB and functions as a promoter-specific regulator of NF-kappaB recruitment to chromatin PMID: 15616592
45. CARM1 affects pre-mRNA splicing in an isoform-specific manner PMID: 15944154
46. arginine methylation of CBP is required for IFN-gamma induction of MHC-II. A kinetic analysis shows that CIITA, CARM1, and H3-R17 methylation all precede CBP loading on the MHC-II promoter during IFN-gamma treatment. PMID: 16254053
47. CARM1 has a role in signal-dependent control of gluconeogenic key enzyme genes PMID: 16330542
48. CARM1 participates in NF-kappaB-mediated transcription through H3-R17 methylation and support a nonnuclear receptor-associated function for CARM1. PMID: 16497732
49. CARM1 is essential for androgen receptor (AR) function and may play a role in prostate cancer progression. PMID: 16705743
50. Results suggest that members of the SRC coactivator family, such as SRC-3, serve as substrates for the enzymatic coactivator coactivator-associated arginine methyltransferase 1 (CARM1). PMID: 16923966

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HGNC: 23393

OMIM: 603934

KEGG: hsa:10498

STRING: 9606.ENSP00000325690

UniGene: Hs.323213