Recombinant Human Krueppel-like factor 13 (KLF13)

Code CSB-YP897476HU
MSDS
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Source Yeast
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Code CSB-EP897476HU
MSDS
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Source E.coli
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Code CSB-EP897476HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP897476HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP897476HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
KLF13
Uniprot No.
Alternative Names
Basic transcription element binding protein 3; Basic transcription element-binding protein 3; BTE binding protein 3; BTE-binding protein 3; BTEB3; C2 H2 zinc finger protein; FKLF 2; FKLF2; Klf13; KLF13_HUMAN; Krueppel-like factor 13; Kruppel like factor 13; Novel Sp1 like zinc finger transcription factor ; Novel Sp1-like zinc finger transcription factor 1; NSLP1; RANTES factor of late activated T lymphocytes 1; RANTES factor of late activated T-lymphocytes 1; RFLAT 1; RFLAT-1; RFLAT1; Transcription factor BTEB3; Transcription factor NSLP1
Species
Homo sapiens (Human)
Expression Region
1-288
Target Protein Sequence
MAAAAYVDHF AAECLVSMSS RAVVHGPREG PESRPEGAAV AATPTLPRVE ERRDGKDSAS LFVVARILAD LNQQAPAPAP AERREGAAAR KARTPCRLPP PAPEPTSPGA EGAAAAPPSP AWSEPEPEAG LEPEREPGPA GSGEPGLRQR VRRGRSRADL ESPQRKHKCH YAGCEKVYGK SSHLKAHLRT HTGERPFACS WQDCNKKFAR SDELARHYRT HTGEKKFSCP ICEKRFMRSD HLTKHARRHA NFHPGMLQRR GGGSRTGSLS DYSRSDASSP TISPASSP
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Represses transcription by binding to the BTE site, a GC-rich DNA element, in competition with the activator SP1. It also represses transcription by interacting with the corepressor Sin3A and HDAC1. Activates RANTES expression in T-cells.
Gene References into Functions
  1. Results show that cg07814318 methylation in blood was significantly associated with obesity and correlated with several obesity-related physical and biochemical traits. The exome sequencing of KLF13 gene in blood identified nine SNPs within its gene body, and two SNPs as cis-meQTL of cg07814318. The sequencing variations within KLF13 genes could drive dynamic modifications of obesity-related CpG methylation. PMID: 28508896
  2. KLF13 functions as a tumor suppressor protein in PCa, and the pharmacological activation of KLF13 might represent a potential approach for the treatment of prostate cancer. PMID: 29843216
  3. Our results suggest the cg07814318 site could be involved in orexigenic processes, and also implicate KLF13 in obesity. Our findings are the first to associate methylation levels in blood with brain activity in obesity-related regions, and further support previous findings between ghrelin, brain activity and genetic differences. PMID: 28194012
  4. KLF13 is critical for the activation of the HPV productive life cycle and is likely involved in initiation and progression of cervical cancer. PMID: 27041562
  5. Knockdown of either FBW7gamma or GSK3beta by small interfering RNA increases KLF13 expression in resting human T lymphocytes. PMID: 22797700
  6. No associations were found between maternal genetic polymorphisms in RANTES (-403G/A) and mother-to-child HIV-1 transmission; plasma, cervical and breastmilk viral loads; or breastmilk chemokine concentrations. PMID: 20518834
  7. KLF13 contributes to malignancy in oral cancer cells and may be a useful biomarker fo early detection and da possible target for therapy. PMID: 20539070
  8. Data support cross-regulation among BMP2, KLF9, and KLF13 to maintain progesterone sensitivity in stromal cells undergoing differentiation and suggest that loss of this network compromises establishment of uterine receptivity and implantation success. PMID: 20410205
  9. protein analysis of BTEB3 and BTEB4 and their binding to CYP1A1 PMID: 12036432
  10. functional domains and DNA-binding sequences PMID: 12050170
  11. A translational rheostat for RFLAT-1 regulates RANTES expression in T lymphocytes. PMID: 12093895
  12. Feedback mechanism for the transcriptional control of the KLF13 gene in the erythroid environment. PMID: 15716005
  13. KLF13 is a key regulator of late RANTES expression in T lymphocytes PMID: 17074812
  14. Coexpression of PRP4 and KLF13 increases nuclear localization of KLF13 and CCL5 transcription. PMID: 17513757
  15. Transient transfection of Kruppel-like factor 4 suppressed LDLR, steroidogenic acute regulatory protein, and CYP11A PMID: 18056793

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Subcellular Location
Nucleus.
Protein Families
Sp1 C2H2-type zinc-finger protein family
Tissue Specificity
Ubiquitous.
Database Links

HGNC: 13672

OMIM: 605328

KEGG: hsa:51621

STRING: 9606.ENSP00000302456

UniGene: Hs.376443

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