Recombinant Human Liprin-alpha-4 (PPFIA4)

Code CSB-YP018440HU
MSDS
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Source Yeast
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Code CSB-EP018440HU
MSDS
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Source E.coli
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Code CSB-EP018440HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP018440HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP018440HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
PPFIA4
Uniprot No.
Alternative Names
KIAA0897; LIPA4_HUMAN; Liprin alpha 4; Liprin-alpha-4; PPFIA 4; PPFIA4; Protein tyrosine phosphatase receptor type f polypeptide (PTPRF) interacting protein (liprin) alpha 4; Protein tyrosine phosphatase receptor type f polypeptide interacting protein alpha 4; Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-4; PTPRF interacting protein alpha 4; PTPRF-interacting protein alpha-4
Species
Homo sapiens (Human)
Expression Region
1-701
Target Protein Sequence
MGSAADVRFS LGTTTHAPPG VHRRYSALRE ESAKDWETSP LPGMLAPAAG PAFDSDPEIS DVDEDEPGGL VGSADVVSPS GHSDAQTLAM MLQEQLDAIN EEIRMIQEEK ESTELRAEEI ETRVTSGSME ALNLKQLRKR GSIPTSLTAL SLASASPPLS GRSTPKLTSR SAAQDLDRMG VMTLPSDLRK HRRKLLSPVS REENREDKAT IKCETSPPSS PRTLRLEKLG HPALSQEEGK SALEDQGSNP SSSNSSQDSL HKGAKRKGIK SSIGRLFGKK EKGRLIQLSR DGATGHVLLT DSEFSMQEPM VPAKLGTQAE KDRRLKKKHQ LLEDARRKGM PFAQWDGPTV VSWLELWVGM PAWYVAACRA NVKSGAIMSA LSDTEIQREI GISNALHRLK LRLAIQEMVS LTSPSAPPTS RTSSGNVWVT HEEMETLETS TKTDSEEGSW AQTLAYGDMN HEWIGNEWLP SLGLPQYRSY FMECLVDARM LDHLTKKDLR VHLKMVDSFH RTSLQYGIMC LKRLNYDRKE LEKRREESQH EIKDVLVWTN DQVVHWVQSI GLRDYAGNLH ESGVHGALLA LDENFDHNTL ALILQIPTQN TQARQVMERE FNNLLALGTD RKLDDGDDKV FRRAPSWRKR FRPREHHGRG GMLSASAETL PAGFRVSTLG TLQPPPAPPK KIMPEAHSHY LYGHMLSAFR D
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
May regulate the disassembly of focal adhesions. May localize receptor-like tyrosine phosphatases type 2A at specific sites on the plasma membrane, possibly regulating their interaction with the extracellular environment and their association with substrates.
Gene References into Functions
  1. The results identify PP1IFA4 loci associated with early onset atrial fibrillation in a Korean population. PMID: 28460022
  2. Data show that liprin-alpha4 plays a pivotal role in inducing malignant phenotypes such as increased proliferation and invasion in pancreatic cancer, and that liprin-alpha4 could be a new effective therapeutic target for pancreatic cancer. PMID: 29187440
  3. presence of Liprin-alpha4 and nickel increased tyrosine phosphatase activity that reduced the global levels of tyrosine phosphorylation in the cell PMID: 21829649
  4. liprin-alpha4 is a hypoxia-induced gene potentially involved in cell-cell adhesion PMID: 20599943
Subcellular Location
Cytoplasm. Cell surface.
Protein Families
Liprin family, Liprin-alpha subfamily
Tissue Specificity
Expressed only in the heart, brain, and skeletal muscle.
Database Links

HGNC: 9248

OMIM: 603145

KEGG: hsa:8497

UniGene: Hs.153648

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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