Recombinant Human Multidrug and toxin extrusion protein 1 (SLC47A1), partial

1. genetic association studies in population in China: Data confirm that an SNP in an intron of SLC47A1 (rs2289669) is associated with hypoglycemic response to metformin in patients with newly diagnosed type 2 diabetes; differential increases in basal GLP1 plasma levels are also related to this SNP. (SLC47A1 = solute carrier family 47 member 1; GLP1 = glucagon-like peptide-1) PMID: 28321905
2. The impact of assay conditions on IC50 determination is negligible, kinetic characteristics differ among used test substrates, and substrate-dependent inhibition exists for MATE1 and MATE2-K, giving valuable insight into the assessment of clinically relevant MATE-mediated drug interactions in vitro. PMID: 27271370
3. Pazopanib inhibits OCT2, MATE1 and MATE2-K, which are involved in cisplatin secretion into urine, potentiating cisplatin toxicity. PMID: 27178732
4. The 5' CpG island of SLC47A1 acts as an enhancer for SLC47A1, and DNA methylation in the CpG island plays a role in interindividual differences in hepatic SLC47A1 expression. PMID: 29070695
5. The combination of ENT1, MATE1 and OCT2 SNPs may serve as a predictive and prognostic marker in metastatic colorectal carcinoma patients treated with TAS-102. PMID: 28992563
6. MATE1 is the major transporter for the cellular uptake of imatinib and crucial for the therapeutic success in CML patients. We suggest that the detailed analysis of MATE1 expression levels and mutations could be a predictor for the response to imatinib therapy. PMID: 27635733
7. This study did not identify any of these known SLC47A1 coding SNPs in the Xhosa individuals who participated in this study. PMID: 27226103
8. substrate identity exerts comparatively little influence on ligand interaction with MATE1. PMID: 27418674
9. MATE1 mRNA levels in peripheral blood cells were significantly higher in patients carrying the minor allele of rs2453579, but not rs2252281, compared to those with other genotypes PMID: 27025966
10. MATE1 polymorphisms were associated with hematological toxicity in non-small cell lung cancer patients. PMID: 27590272
11. MATE1 rs2289669 may be a significant determinant in the renal clearance of metformin in the case of transporter-mediated drug interactions PMID: 26784938
12. Disease progression according to RECIST was also more frequent in carriers of at least one polymorphic MATE1 A-allele (44%) as compared with homozygous carriers of the wild-type G-allele (12.5%) (P=0.07). OCT1 and MATE1 were not associated with PFS. PMID: 25753371
13. MATE1 sequesters organic cations within an intracellular compartment that has no influence on secretion in renal proximal tubules. PMID: 26538438
14. SLC47A1 rs2289669 G>A variants improve the glucose-lowering effect of metformin through slowing its excretion in type 2 diabetes populations. PMID: 26004431
15. MRNA levels of multidrug and toxin extrusion protein 1 (MATE1 or SLC47A1, encoded by 1 of the 11 genes) were significantly lower in patients with FILI. PMID: 25862351
16. MATE1 is a membrane transporter for quercetin.MATE1 was highly expressed in peroxisomes and the endoplasmic reticulum as well as in plasma membranes in the liver and intestine. PMID: 25241911
17. ADMA and L-arginine are substrates of human CAT2A, CAT2B, OCT2 and MATE1. Transport kinetics of CAT2A, CAT2B, and OCT2 indicate a low affinity, high capacity transport, which may be relevant for renal and hepatic elimination of ADMA or L-arginine PMID: 23864433
18. The results confirmed that OAT1, OAT3, OCT2, MATE1, and MATE2-K were coexpressed in tubular epithelial cells. PMID: 23630107
19. Decreasing expression of OCT3 and MATE1 in human placenta indicates these transporters may play a role in fetal protection preferentially at earlier stages of gestation. PMID: 23303678
20. The 808G>T single-nucleotide polymorphism in OCT2 ameliorated cisplatin-induced nephrotoxicity without alteration of disposition, whereas the rs2289669 G>A single-nucleotide polymorphism in MATE1 had no effect on cisplatin toxicity. PMID: 22569819
21. Twenty percent of patients with diabetes that are homozygous for A-allele of SLC47A1 had twofold reduction in HbA1c in comparison with the patients carrying G-allele. PMID: 22882994
22. Seven polymorphisms in OCT1, OCT2, and MATE1 genes were compared between 53 type 2 diabetes patients with side effects of metformin and 193 metformin users without symptoms of metformin intolerance. PMID: 22735389
23. The effect of novel promoter variants in MATE1 ... on the pharmacokinetics and pharmacodynamics of metformin PMID: 23267855
24. Twelve transmembrane helices form the functional core of mammalian MATE1 (multidrug and toxin extruder 1) protein. PMID: 22722930
25. Homozygous MATE1 variant could be one of the risk factors for metformin-induced lactic acidosis. PMID: 22242910
26. The results suggest that agmatine disposition may be influenced by hOCT2 and hMATE1, two transporters critical in the renal elimination of xenobiotic compounds. PMID: 21128598
27. 4',6-diamidino-2-phenylindole (DAPI) can be used as a probe substrate for rapid assays of the functionality of the human MATE1 PMID: 20047987
28. This study showed that coordinate function of MATE1 with OCT2 likely contributes to the vectorial renal elimination of organic cationic drugs and that altered activity of MATE1 should be considered as a determinant of renal cationic drug elimination. PMID: 20053795
29. characterization of MATE1: kinetic analysis of transport of cimetidine and tetraethylammonium; inhibitors; comparison to hMATE2-K and rMATE1 PMID: 20067714
30. The purpose of this study was to evaluate the effects of heterozygous MATE variants on the disposition of metformin in mice and humans. PMID: 20016398
31. These findings suggested that the loss of transport activities of the MATE1 G64D and MATE2-K G211V variants were due to the alteration of protein expression in cell surface membranes. PMID: 19158817
32. interaction between polymorphisms and OCT1 polymorphisms on the glucose lowering effect of metformin PMID: 19898263
33. MATE1 appears to be the long searched for polyspecific organic cation exporter that directly transports toxic organic cations into urine and bile. PMID: 16330770
34. an oppositely directed H(+) gradient serves as a driving force of tetraethylammonium transport via rMATE1 PMID: 17047166
35. The results suggest that hOCT2 and hMATE1 mediate paraquat transport in the kidney. PMID: 17495125
36. hMATE1 and hMATE2-K function together as a detoxication system, by mediating the tubular secretion of intracellular ionic compounds across the brush-border membranes of the kidney. PMID: 17509534
37. Sp1 functions as basal transcriptional regulator of human and rat MATE1 gene through two GC boxes. May be conserved among species. We have identified rSNP of hMATE1 gene (G-32A) (belonging to Sp1-binding site) that affects promoter activity. PMID: 17855482
38. The molecular basis of substrate recognition by MATE1 was investigated via amino acid substitution in the conserved transmembrane regions. PMID: 18305230
39. Genetic variants in multidrug and toxic compound extrusion-1, hMATE1, alter transport function. PMID: 19172157
40. Guanin/adenine single nucleotide polymorphism is associated with a reduction in A1C level suggesting it role in the pharmacokinetics of metformin in diabetics. PMID: 19228809
41. the rate of transcription of MATE1 is regulated by AP-1 and AP-2rep and that a common promoter variant, g.-66T>C may affect the expression level of MATE1 in human kidney, and ultimately result in variation in drug disposition and response. PMID: 19745787

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HGNC: 25588

OMIM: 609832

KEGG: hsa:55244

STRING: 9606.ENSP00000270570

UniGene: Hs.232054