Recombinant Human N-alpha-acetyltransferase 10 (NAA10)

1. Since the FIH-1 dependent hydroxylation of NAA10 occurs oxygen-dependently, NAA10 acetylates HIF-1alpha under normoxia but does not under hypoxia. PMID: 30237125
2. In combination with acetylation assays, the HypK N-terminal region is identified as a negative regulator of the NatA acetylation activity PMID: 28585574
3. ARD1-mediated Hsp70 acetylation is a regulatory mechanism that temporally balances protein refolding/degradation in response to stress PMID: 27708256
4. Negative regulation of Naa10 towards NTN1 and its receptor UNC5B were also detected upon treatment of all-trans retinoid acid, which was often used to induce morphological differentiation. PMID: 27910960
5. A novel de novo NAA10 c.332 T>G p.(Val111Gly) missense variant was detected in a girl with mild/moderate non-syndromic intellectual disability. NAA10 V111G displayed reduced monomeric NAT activity and stability, but intact NatA-mediated NAT activity. PMID: 29558889
6. Expression of ARD1 increases levels of androgen receptor acetylation and androgen receptor-HSP90 dissociation in a dose dependent manner. PMID: 27659526
7. Study reports on a total of 12 affected females with four different de novo missense mutations in NAA10 and one inherited mutation in a familial case due to germline mosaicism, thus further expanding themutational and clinical spectrum associated with NAA10 related N-terminal-acetyltransferase deficiency. PMID: 27094817
8. our study illustrated that the expression of Naa10p had a potential value for predicting the progression of OSCC and prognosis of OSCC patients. PMID: 26662107
9. The results observed an inverse correlation between the expression of NAA10 and that of miR-342-5p and miR-608 . PMID: 26646451
10. Human Naa15 (NATH) and Naa10 (ARD1) form a stable NatA complex which associates with ribosomes and performs co-translational N-terminal acetylation; Naa15 (NATH) and Naa10 (ARD1) are cleaved during apoptosis resulting in decreased acetyltransferase activity PMID: 15496142
11. The clinical spectrum of NAA10. PMID: 26522270
12. there is no difference in lysine acetylation of substrate proteins with or without Naa10, suggesting that the substrates may be acetylated chemically rather than enzymatically. PMID: 26755727
13. Combined high expression of Naa10p, SNCG and PRL-3 are associated with lymph node metastasis in breast cancer. PMID: 25854368
14. De novo missense mutations in the NAA10 gene cause severe non-syndromic developmental delay in males and females PMID: 25099252
15. human ARD1 variants have different effects on cell proliferation, which may result from distinct subcellular localizations and autoacetylation activities. PMID: 25421966
16. Naa10 structure and function. [Review] PMID: 25987439
17. Autoacetylation of ARD1 variants differentially regulates angiogenesis and cell proliferation in an isoform-specific manner. PMID: 25338643
18. ARD1 has a crucial role in the cellular response to oxidative stress as a bona fide regulator of MSRA. PMID: 25341044
19. Naa10p inhibits the metastasis of breast cancer cells by targeting STAT5a. PMID: 24925029
20. results show that hARD1 nuclear translocation mediated by NLS is required for cell cycle progression, thereby contributing to proper cell proliferation. PMID: 25133627
21. Study describes a Saccharomyces cerevisiae model developed by introducing the human wild-type (wt) or mutant NatA complex into yeast lacking NatA (NatA-Delta). The wt human NatA complex phenotypically complemented the NatA-Delta strain, whereas only a partial rescue was observed for the Ogden mutant NatA complex suggesting that hNaa10 S37P is only partially functional in vivo. PMID: 24408909
22. The study concludes that the NAA10 mutation is the cause of Lenz microphthalmia syndrome in a family, likely through the dysregulation of the retinoic acid signalling pathway. PMID: 24431331
23. Protein N-terminal acetyltransferases (NATs), including Naa10, act as N-terminal propionyltransferases. PMID: 23043182
24. Development of the first specific NAT-inhibitors, including inhibitors targeting Naa10. PMID: 23557624
25. Structural characterization of native hARD1 using size exclusion chromatography, circular dichroism, & fluorescence spectroscopy shows the protein consists of compact globular region comprising 2 thirds of the protein & a flexible unstructured C terminus. PMID: 16823041
26. ARD1 functions as an inhibitor of the mTOR pathway and that dysregulation of the ARD1-TSC2-mTOR axis may contribute to cancer development PMID: 20145209
27. These results indicate that ARD1A is a novel tumor-associated antigen and a potential prognostic factor for colon cancer. PMID: 20639454
28. The expression level of NAA10 is inversely correlated with that of MMP-9 in breast cancer samples. PMID: 23550278
29. Naa10p suppresses 28S proteasome activity through interaction with PA28beta. PMID: 23624078
30. These data indicate that the interaction between ARD1 and RIP1 plays an important role in the DNA damage-induced NF-kappaB activation, and that the acetyltransferase activity of ARD1 and its localization in to the nucleus are involved in such stress response. PMID: 22580278
31. study revealed a novel mechanism controlling MCL1 expression, in which Naa10p and RelA/p65 synergistically interact with MCL1 promoter region and promote MCL1 transcription PMID: 22496479
32. Arrest-defective protein 1 homolog A (ARD1) in combination with SNCG/Hiwi/PRL-3 may lead to a poor outcome in patients with or without lymph node metastatic colon cancer. PMID: 22261620
33. ARD1 functions as a unique AR regulator in prostate cancer cells. PMID: 22315407
34. A reduction in acetylation by hNaa10p causes lethal X-linked disorder of infancy. PMID: 21700266
35. N(alpha)-acetyltransferase 10 may function as a post-translational actin N(alpha)-acetyltransferase. PMID: 21383206
36. suggest that Naa10p functions as a tumor metastasis suppressor by disrupting the migratory complex, PIX-GIT- Paxillin, in cancer cells PMID: 21295525
37. interaction between hNaa10p and DNMT1 was required for E-cadherin silencing through promoter CpG methylation, and E-cadherin repression contributed to the oncogenic effects of hNaa10p. PMID: 20592467
38. Results show that hARD1 autoacetylation is critical for its activation and its ability to stimulate cancer cell proliferation and tumorigenesis. PMID: 20501853
39. Data indicate that the physical interaction between HYPK and NatA Naa10/15 seems to be of functional importance both for huntingtin aggregation and for N-terminal acetylation. PMID: 20154145
40. hARD1 is a bona fide regulator of MLCK, and hARD1 plays a crucial role in the balance between tumor cell migration and stasis PMID: 19826488
41. ARD1-mediated acetylation regulates and destabilizes HIF-1 alpha by directly binding to it. PMID: 12464182
42. description of the human homologue of Nat1p, NATH (NAT human), as the binding partner of the hARD1 (human ARD1) protein PMID: 15496142
43. Amino-terminal acetyltransferase ARD1 (hARD1) interacts with a novel motif, 658-HGVVEVD-664, in the cytoplasmic domain of beta-amyloid precursor protein. PMID: 15749829
44. ARD1 is involved in cell proliferation and in regulating a series of cellular metabolic pathways that are regulated during hypoxia response. PMID: 15755738
45. Data demonstrate that ARD1 has limited, if any, impact on the HIF-1alpha signaling pathway. PMID: 15994306
46. levels of endogenous NATH and hARD1 proteins in thyroid papillary carcinoma patients; results suggest that NATH positively affects the level of hARD1 protein both in vivo and in cell cultures PMID: 16279846
47. ARD1 specifically binds HIF-1 alpha, suggesting a putative, still unclear, connection between these proteins. PMID: 16288748
48. A human ARD1 variant ortholog (235) has weak effects on hypoxia inducible factor (HIF)-1 alpha and VEGF mRNA stability compared to mouse ARD1 ortholog 225. PMID: 16376303
49. Essential role in cell survival through protein N-alpha-acetylation. PMID: 16518407
50. These results indicate that ARD1(235) and ARD1(225) isoforms may have different activities and function in different subcellular compartments of mammalian cells. PMID: 17161380

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HGNC: 18704

OMIM: 300013

KEGG: hsa:8260

STRING: 9606.ENSP00000417763

UniGene: Hs.433291