Recombinant Human Neutral amino acid transporter B (0) (SLC1A5), partial

1. Data suggest that amino acid uptake via ASCT2/SLC1A5 is required for cell proliferation/tumor growth independently of LAT1/SLC7A5; in part, these studies were conducted in lung and colon adenocarcinoma cell lines and involved gene knockout techniques. (ASCT2/SLC1A5 = solute carrier family-1 member-5; LAT1/SLC7A5 = solute carrier family-7 member-5) PMID: 29326164
2. This study provides the metabolic molecule SLC1A5 as a potential therapeutic target to increase the efficacy of cetuximab on colorectal cancer PMID: 29363109
3. Results demonstrated that ASCT2 and pmTOR protein levels were significantly higher in epithelial ovarian cancer (EOC) tissues and predicting a poor prognosis. The expression levels of ASCT2 and pmTOR in EOC were positively correlated indicating a synergistic effect on the growth and development of early EOC. PMID: 30272366
4. intronic variants of the ASCT2 gene have roles in hampering the splicing process and in longevity PMID: 28885889
5. These data collectively establish that in an in vitro context, human epithelial and mesenchymal hepatocellular carcinoma cell lines adapt to ASCT2 or LAT1 knockout. PMID: 30029480
6. SLC1A5 expression is increased in tumor samples from esophageal cancer patients, and downregulation of SLC1A5 inhibited cell cycle progression and esophageal cancer growth. PMID: 30071532
7. Our results indicate that overexpression of SLC1a5 is associated with shorter overall survival in non-small cell lung cancer PMID: 29455869
8. the experimental data allowed identifying C467 residue as crucial for substrate binding and for transport activity modulation of hASCT2. PMID: 29495336
9. ASCT2 was significantly overexpressed in the gastric cancer (GC) samples compared with adjacent non-cancerous gastric mucosa, in contrast, a significantly higher level of glutamine synthetase (GS) expression was observed in normal tissues than in GC samples compared with adjacent non-cancerous gastric mucosa. PMID: 29435734
10. These results indicated that ASCT2 (SLC1A5) could be a novel therapeutic target against KRAS-mutant colorectal cancer. PMID: 28749408
11. AR signaling promoted glutamine metabolism by increasing the expression of the glutamine transporters SLC1A4 and SLC1A5, genes commonly overexpressed in prostate cancer. Correspondingly, gene expression signatures of AR activity correlated with SLC1A4 and SLC1A5 mRNA levels in clinical cohorts. PMID: 28507054
12. Results provide evidence that ASCT2 enhances glutamine uptake in glycolipid-enriched microdomain/rafts in GD2(+) small-cell lung cancer cells, leading to the enhancement of cell proliferation and migration. PMID: 29151270
13. High ASCT2 expression is associated with head and neck squamous cell carcinoma. PMID: 28823958
14. this study shows that IL-2-induced expression of SLC1A5 is a prerequisite for NKG2D-mediated activation of NK cells PMID: 28784848
15. Data suggest that both heterogeneous nuclear ribonucleoprotein type M (HNRPM) and solute carrier 1A5 (SLC1A5) have role in the pathogenesis of ovarian cancer. PMID: 28609484
16. Both stable and inducible shRNA-mediated ASCT2 knockdown confirmed that inhibiting ASCT2 function was sufficient to prevent cellular proliferation and induce rapid cell death in TN basal-like breast cancer cells, but not in luminal cells. PMID: 26455325
17. ASCT2 is an EGFR-associated protein that can be co-targeted by cetuximab, leading to sensitization of cetuximab-treated cells to ROS-induced apoptosis. PMID: 27450723
18. The tumor metabolism status determined by expression of GLUT1 and ASCT2. PMID: 28036362
19. Data show that SERT associates with ASCT2 (alanine-serine-cysteine-threonine 2), a member of the solute carrier 1 family co-expressed with SERT in serotonergic neurons and involved in the transport of small neutral amino acids across the plasma membrane. PMID: 27143784
20. In the absence of SLC1A5 there is a crucial role of SNAT1 in supplying glutamine for glutaminolysis with SNAT2 acting as a "backup" for glutamine transport. PMID: 27129276
21. High expression of LAT1 and ASCT2 correlates with metastasis and invasion in esophageal squamous cell carcinoma. PMID: 26936531
22. LAT1, 4F2hc and ASCT2 were highly expressed in patients with advanced laryngeal cancer. PMID: 26024742
23. Cys is a potent competitive inhibitor of hASCT2 but is not a substrate PMID: 26492990
24. Genetic Variants in ASCT2 Gene are Associated with response to therapy in Hepatocelluar Carcinoma PMID: 25987094
25. ASCT2 expression plays an important role in tumour cell growth, and is a promising pathological marker for predicting a worse outcome in pancreatic cancer. PMID: 24845232
26. The results demonstrate that N-glycosylation of SLC1A5 is critical for trafficking. PMID: 25862406
27. ASCT2-mediated glutamine uptake is essential for multiple pathways regulating the cell cycle and cell growth. PMID: 25693838
28. ASCT-2 is expressed in human oocytes.ASCT-2 is localized at the acrosomal region and equatorial segment of the spermatozoa. PMID: 24687878
29. Report the differential expression of SLC1A5 in human colorectal cancer and normal tissues, and a functional link between SLC1A5 expression and growth and survival of colorectal cancer. PMID: 25337245
30. analysis of the kinetic mechanism of the transport catalyzed by the human glutamine/neutral amino acid transporter hASCT2 PMID: 25052780
31. ASCT2 expression, which correlates with that of N-Myc and ATF4, is markedly elevated in high-stage neuroblastoma PMID: 25142020
32. the expression of LAT1 and ASCT2 is significantly increased in human melanoma. The importance of ASCT2 expression in melanoma was confirmed by shRNA knockdown, which inhibited glutamine uptake, mTORC1 signaling and cell proliferation. PMID: 24531984
33. ASC amino-acid transporter 2 expression has a crucial role in the metastasis of pulmonary AC, and is a potential molecular marker for predicting poor prognosis after surgery. PMID: 24603303
34. HER2- type breast cancer had the highest expression of stromal GLS1, tumoral GDH, stromal GDH, and tumoral ASCT, while TNBC had the lowest tumoral GDH expression. PMID: 23507704
35. stromal expression of the glutamine-metabolism-related proteins GLS1, GDH, ASCT2 increases with worsening histological phyllodes tumor grade. PMID: 23636801
36. SLC1A5 plays a key role in Gln transport controlling lung cancer cells' metabolism, growth, and survival. PMID: 23213057
37. These data suggest that intracellular replication of Francisella tularensis depends on the function of host cell SLC1A5. PMID: 22804921
38. Cx43-mediated GJIC and SLC1A5 interaction play important functional roles in trophoblast cell fusion. PMID: 22238282
39. level of amino acid transporter B(0)(ACST2) mRNA expression was lower in forskolin treated BeWo cells PMID: 12175968
40. in the six unrelated Hartnup pedigrees studied, examination of linkage at 19q13.3, polymorphisms in the coding sequence and quantitation of expression of SLC1A5 did not suffice to explain the defect in neutral amino acid transport PMID: 12555937
41. Hypoxia alters expression and function of syncytin and its receptor (amino acid transport system B(0)) during trophoblast cell fusion of human placental BeWo cells: implications for impaired trophoblast syncytialisation in pre-eclampsia. PMID: 12757936
42. ASCT2 messenger RNA was not altered significantly in hypoxia in cytotrophoblasts or in perfused placental cotyledons. PMID: 14520239
43. up-regulation of ASCT2 by S-nitroso-N-acetyl-DL-penicillamine might be partially associated with an increase in the density of transporter protein via de novo synthesis PMID: 15848195
44. analysis of SLC1A5 mutations on 19q13 in cystinuria patients PMID: 16435221
45. evaluation of the interaction of the HERV-W envelope with the hASCT2 receptor; a region consisting of the N-terminal 124 amino acids of the mature glycoprotein surface subunit was determined as the minimal receptor-binding domain PMID: 16820059
46. ASCT2 silencing inhibits mTORC1 (mTOR/raptor) signaling and leads to growth repression, followed by enhanced survival signaling via mTORC2 (mTOR/rictor comples) and apoptosis of hepatoma cells. PMID: 17329400
47. Localisation and distribution of RDR/ASCT2 in human placental villi suggests that the fusion of placental trophoblast cells is not regulated by local or temporal variations of RDR/ASCT2 expression in villous cytotrophoblast cells. PMID: 17676482
48. In human entrocytes, glutamine transport and ASCT2 surface expression induced by short-term EGF are MAPK, PI3K, and Rho-dependent. PMID: 18157695
49. SLC1A5 gene is associated with schizophrenia. PMID: 18638388
50. In primary term human trophoblasts, ASCT2 mRNA levels were preserved at normoxia and downregulated at 1% O(2) after 48 h. PMID: 19321927

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HGNC: 10943

OMIM: 109190

KEGG: hsa:6510

STRING: 9606.ENSP00000444408

UniGene: Hs.631582