Recombinant Human Nuclear pore complex protein Nup214 (NUP214), partial

1. SQSTM1-Nup214, although mostly cytoplasmic, also forms nuclear bodies and inhibits nuclear protein but not poly(A)(+) RNA export. PMID: 27613868
2. We have identified NUP214, a member of the massive nuclear pore complex, as a novel miR-133b target. PMID: 25743594
3. Both in vitro hexon binding and in vivo nuclear import of the adenovirus genome were strongly reduced in Nup214-depleted cells suggesting that Nup214 is a major binding site of adenovirus during infection. PMID: 25410864
4. NUP214-ABL1-mediated cell proliferation in T-cell acute lymphoblastic leukemia is dependent on the LCK kinase and various interacting proteins. PMID: 23872305
5. When compared with SET-NUP214-negative patients, SET-NUP214-positive patients showed a significantly higher rate of corticosteroid resistance (91% vs 44%; P = .003) and chemotherapy resistance (100% vs 44%; P = .0001). PMID: 24449214
6. The expression of endogenous Nup214 is significantly down-regulated by the reverse inserted lentiviral promoter PMID: 23831628
7. Nucleoporin p62 (NUP62) and nucleoporin 214 (NUP214) are differentially distributed between nuclear pore complexes. PMID: 22558357
8. Data describe the relatively high incidence of SET-NUP214 rearrangement in adult T-ALLs, and demonstrate comprehensive clinical, phenotypic, and genetic characteristics of this entity. PMID: 21720744
9. Used MALDI-TOF MS 40-plex assay for testing 40 loci within 21 high-ranking breast cancer CAN-genes. No mutation could be found in 6 cell lines. A single breast cancer tissue sample showed heterozygosity at locus c.5834G>A within the ZFYVE26 gene. PMID: 21691751
10. NUP214-ABL1 positive T-cell acute lymphoblastic leukemia patient shows an initial favorable response to imatinib therapy post relapse PMID: 21489623
11. Cell lines LOUCY and MEGAL express the recently described SET-NUP214 fusion gene. PMID: 19166587
12. Smad2 nucleocytoplasmic shuttling by nucleoporins CAN/Nup214 and Nup153 feeds TGFbeta signaling complexes in the cytoplasm and nucleus. PMID: 12191473
13. A surface hydrophobic corridor within the MH2 domain of Smad3 is critical for association with CAN/Nup214 and nuclear import, whereas Smad4 interaction with CAN/Nup214, and nuclear import requires structural elements present only in the full-length Smad4 PMID: 12917407
14. leukemia SET-CAN fusion protein inhibited proliferation of U937 cells, most likely by interfering with hCRM1, but it also partially blocks differentiation PMID: 14671643
15. Nup214 has a role in regulating TTP localization PMID: 14766228
16. NUP214-ABL1 expression defines a new subgroup of individuals with T-ALL PMID: 15361874
17. A mechanism is proposed by which the C-terminal peptide extension is involved in nuclear pore complex assembly. PMID: 17264208
18. TAF-Ialpha/CAN and TAF-Ibeta/CAN fusion transcripts are generated by chromosome 9q34 deletion in acute myeloid leukemia PMID: 17296573
19. Impairment of erythroid and megakaryocytic differentiation by a leukemia-associated and t(9;9)-derived product, SET/TAF-IBeta-CAN/Nup214. PMID: 17620317
20. Set/TAF-Ibeta acts as a ligand-activated GR-responsive transcriptional repressor, while Set-Can does not retain physiologic responsiveness to ligand-bound glucocorticoid receptor. PMID: 18096310
21. SET-NUP214 binds in the promoter regions of specific HOXA genes, where it interacts with CRM1 and DOT1L, which may transcriptionally activate specific members of the HOXA cluster. PMID: 18299449
22. NUP214-ABL1 fusion is unique because of its requisite localization to the nuclear pore complex for its transforming potential. PMID: 18614052
23. a thorough biochemical comparative analysis of NUP214-ABL1 and BCR-ABL1 show that, despite their common tyrosine kinase domain, the two fusion proteins differ in many critical catalytic properties PMID: 18784740
24. FISH revealed a heterogeneous pattern of NUP214-ABL1 amplification. NUP214-ABL1 gene requires amplification for oncogenicity; it is part of a multistep process of leukemogenesis; and it can be a late event present only in subpopulations PMID: 18923437
25. Using in vitro assays, the authors demonstrate that NUP214 decreases both the RNA binding and ATPase activities of DBP5. PMID: 19219046
26. CAN/Nup214 is a nuclear receptor for the herpesvirus capsid. PMID: 19386703
27. Nup214 domain-specific localization by immunoelectron microscopy. Transport studies show that the spatial distribution of the FG-repeat domains of both Nup153 and Nup214 shifts in a transport-dependent manner. PMID: 16045929

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HGNC: 8064

OMIM: 114350

KEGG: hsa:8021

STRING: 9606.ENSP00000352400

UniGene: Hs.654530