Recombinant Human Nuclear transition protein 2 (TNP2)

Code CSB-YP024019HU
MSDS
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Source Yeast
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Code CSB-EP024019HU
MSDS
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Source E.coli
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Code CSB-EP024019HU-B
MSDS
Size Pls inquire
Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP024019HU
MSDS
Size Pls inquire
Source Baculovirus
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Code CSB-MP024019HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
TNP2
Uniprot No.
Alternative Names
TNP2; Nuclear transition protein 2; TP-2; TP2
Species
Homo sapiens (Human)
Expression Region
1-138
Target Protein Sequence
MDTQTHSLPI THTQLHSNSQ PQSRTCTRHC QTFSQSCRQS HRGSRSQSSS QSPASHRNPT GAHSSSGHQS QSPNTSPPPK RHKKTMNSHH SPMRPTILHC RCPKNRKNLE GKLKKKKMAK RIQQVYKTKT RSSGWKSN
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Gene References into Functions
  1. the quantity of PRM1, PRM2, and TNP2 transcripts and the PRM1/PRM2 mRNA ratio affect spermiogenesis, sperm morphology PMID: 25536093
  2. MiR-122 may influence spermatozoa-like cells by suppressing TNP2 expression and inhibiting the expression of proteins associated with sperm development. PMID: 23327642
  3. analysis of the TNP2 gene did not show any association with infertility. PMID: 20522125
  4. Acetylation of transition protein 2 (TP2) by KAT3B (p300) alters its DNA condensation property and interaction with putative histone chaperone NPM3. PMID: 19710011
Subcellular Location
Nucleus. Chromosome.
Protein Families
Nuclear transition protein 2 family
Tissue Specificity
Expressed by spermatids (at protein level).
Database Links

HGNC: 11952

OMIM: 190232

KEGG: hsa:7142

STRING: 9606.ENSP00000325738

UniGene: Hs.513349

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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