TNP2 Antibody

Code CSB-PA024019LA01HU
Size US$166
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Image
  • IHC image of CSB-PA024019LA01HU diluted at 1:200 and staining in paraffin-embedded human testis tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

  • Immunofluorescence staining of Hela cells with CSB-PA024019LA01HU at 1:66, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) TNP2 Polyclonal antibody
Uniprot No.
Target Names
TNP2
Alternative Names
TNP2 antibody; Nuclear transition protein 2 antibody; TP-2 antibody; TP2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Nuclear transition protein 2 protein (1-138AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The TNP2 Antibody (Product code: CSB-PA024019LA01HU) is Non-conjugated. For TNP2 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA024019LB01HU TNP2 Antibody, HRP conjugated ELISA
FITC CSB-PA024019LC01HU TNP2 Antibody, FITC conjugated
Biotin CSB-PA024019LD01HU TNP2 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:200-1:500
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a key role in the replacement of histones to protamine in the elongating spermatids of mammals. In condensing spermatids, loaded onto the nucleosomes, where it promotes the recruitment and processing of protamines, which are responsible for histone eviction.
Gene References into Functions
  1. the quantity of PRM1, PRM2, and TNP2 transcripts and the PRM1/PRM2 mRNA ratio affect spermiogenesis, sperm morphology PMID: 25536093
  2. MiR-122 may influence spermatozoa-like cells by suppressing TNP2 expression and inhibiting the expression of proteins associated with sperm development. PMID: 23327642
  3. analysis of the TNP2 gene did not show any association with infertility. PMID: 20522125
  4. Acetylation of transition protein 2 (TP2) by KAT3B (p300) alters its DNA condensation property and interaction with putative histone chaperone NPM3. PMID: 19710011
Subcellular Location
Nucleus. Chromosome.
Protein Families
Nuclear transition protein 2 family
Tissue Specificity
Expressed by spermatids (at protein level).
Database Links

HGNC: 11952

OMIM: 190232

KEGG: hsa:7142

STRING: 9606.ENSP00000325738

UniGene: Hs.513349

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