Recombinant Human Rab proteins geranylgeranyltransferase component A 2 (CHML)

Code CSB-YP005357HU
MSDS
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Source Yeast
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Code CSB-EP005357HU
MSDS
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Source E.coli
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Code CSB-EP005357HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP005357HU
MSDS
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Source Baculovirus
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Code CSB-MP005357HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
CHML
Uniprot No.
Alternative Names
CHM like; Chml; Choroideraemia like protein; Choroideraemia-like protein; Choroideremia like (Rab escort protein 2); Choroideremia like; Choroideremia like protein; Rab escort protein 2; Rab proteins geranylgeranyltransferase component A 2; RAE2_HUMAN; REP 2; REP-2; REP2
Species
Homo sapiens (Human)
Expression Region
1-656
Target Protein Sequence
MADNLPTEFD VVIIGTGLPE SILAAACSRS GQRVLHIDSR SYYGGNWASF SFSGLLSWLK EYQQNNDIGE ESTVVWQDLI HETEEAITLR KKDETIQHTE AFCYASQDME DNVEEIGALQ KNPSLGVSNT FTEVLDSALP EESQLSYFNS DEMPAKHTQK SDTEISLEVT DVEESVEKEK YCGDKTCMHT VSDKDGDKDE SKSTVEDKAD EPIRNRITYS QIVKEGRRFN IDLVSKLLYS QGLLIDLLIK SDVSRYVEFK NVTRILAFRE GKVEQVPCSR ADVFNSKELT MVEKRMLMKF LTFCLEYEQH PDEYQAFRQC SFSEYLKTKK LTPNLQHFVL HSIAMTSESS CTTIDGLNAT KNFLQCLGRF GNTPFLFPLY GQGEIPQGFC RMCAVFGGIY CLRHKVQCFV VDKESGRCKA IIDHFGQRIN AKYFIVEDSY LSEETCSNVQ YKQISRAVLI TDQSILKTDL DQQTSILIVP PAEPGACAVR VTELCSSTMT CMKDTYLVHL TCSSSKTARE DLESVVKKLF TPYTETEINE EELTKPRLLW ALYFNMRDSS GISRSSYNGL PSNVYVCSGP DCGLGNEHAV KQAETLFQEI FPTEEFCPPP PNPEDIIFDG DDKQPEAPGT NNVVMAKLES SEESKNLESP EKHLQN
Protein Length
Full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. Less effective than CHM in supporting prenylation of Rab3 family.
Gene References into Functions
  1. Polymorphisms in the OPN3 and CHML genes are associated with asthma and atopic asthma. PMID: 18344558
Subcellular Location
Cytoplasm, cytosol.
Protein Families
Rab GDI family
Database Links

HGNC: 1941

OMIM: 118825

KEGG: hsa:1122

STRING: 9606.ENSP00000355511

UniGene: Hs.654545

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