Recombinant Human Retinoic acid receptor beta(RARB)

Code CSB-YP019339HU
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Source Yeast
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Code CSB-EP019339HU
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Source E.coli
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Code CSB-EP019339HU-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP019339HU
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Source Baculovirus
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Code CSB-MP019339HU
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names RARB
Uniprot No. P10826
Alternative Names HAP; HBV-activated protein; NR1B2; Nuclear receptor subfamily 1 group B member 2; RAR B; RAR beta; RAR epsilon; RAR-beta; RAR-epsilon; RARB; RARB_HUMAN; Retinoic acid receptor beta 2; Retinoic acid receptor beta 4; Retinoic acid receptor beta 5; Retinoic acid receptor beta; Retinoic acid receptor beta polypeptide; RRB2
Species Homo sapiens (Human)
Expression Region 1-455
Target Protein Sequence MTTSGHACPV PAVNGHMTHY PATPYPLLFP PVIGGLSLPP LHGLHGHPPP SGCSTPSPAT IETQSTSSEE LVPSPPSPLP PPRVYKPCFV CQDKSSGYHY GVSACEGCKG FFRRSIQKNM IYTCHRDKNC VINKVTRNRC QYCRLQKCFE VGMSKESVRN DRNKKKKETS KQECTESYEM TAELDDLTEK IRKAHQETFP SLCQLGKYTT NSSADHRVRL DLGLWDKFSE LATKCIIKIV EFAKRLPGFT GLTIADQITL LKAACLDILI LRICTRYTPE QDTMTFSDGL TLNRTQMHNA GFGPLTDLVF TFANQLLPLE MDDTETGLLS AICLICGDRQ DLEEPTKVDK LQEPLLEALK IYIRKRRPSK PHMFPKILMK ITDLRSISAK GAERVITLKM EIPGSMPPLI QEMLENSEGH EPLTPSSSGN TAEHSPSISP SSVENSGVSQ SPLVQ
Protein Length Full length protein
Tag Info The following tags are available.
N-terminal His-tagged
Tag-Free
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting
and FAQs
Protein FAQs
Storage Condition Store at -20°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

Target Data

Function Receptor for retinoic acid. Retinoic acid receptors bind as heterodimers to their target response elements in response to their ligands, all-trans or 9-cis retinoic acid, and regulate gene expression in various biological processes. The RXR/RAR heterodimers bind to the retinoic acid response elements (RARE) composed of tandem 5'-AGGTCA-3' sites known as DR1-DR5. In the absence or presence of hormone ligand, acts mainly as an activator of gene expression due to weak binding to corepressors. In concert with RARG, required for skeletal growth, matrix homeostasis and growth plate function.
Gene References into Functions
  1. Hypermethylation of RARB gene is associated with high grade lung cancer. PMID: 29851970
  2. RAR-beta expression state is one of the independent factors for the prognosis of lung squamous cell carcinoma patients PMID: 29077166
  3. Although studies reported different rates for RAR beta promoter methylation in prostate can tissues, the total meta-analysis demonstrated that RAR beta promoter methylation may be correlated with prostate cancer carcinogenesis and that the RAR beta gene is particularly susceptible. PMID: 29554659
  4. Hypermethylation frequency of CpG islands in the promoters of retinoic acid receptor beta gene (RAR-beta) gene was respectively 61 and 33% for diffuse and intestinal type n gastric cancer tissues. PMID: 28759951
  5. There were significant associations between RARB promoter hypermethylation and Oral Cancer risk. PMID: 29538221
  6. Results indicate that RARbeta hypermethylation correlates well with an increased risk in non-small cell lung cancer (NSCLC) patients. RARbeta gene inactivation caused by RARbeta methylation contributes the NSCLC tumorigenesis and may serve as a potential risk factor, diagnostic marker and drug target of NSCLC. [review] PMID: 28008143
  7. retinoic acid receptor beta-retinoic X receptor alpha heterodimer quaternary architecture variable PMID: 29021580
  8. Data shows that miR-106a directly targets RARB 3'-UTR and the miR-106a-RARB complex promotes the viability of thyroid cancer. PMID: 27342319
  9. Study identified a novel mutation in RARB gene in patients with intellectual disability and progressive motor impairment which confers gain-of-function further promoting the retinoic acid (RA) ligand-induced transcriptional activity by twofold to threefold over the wild-type receptor. These results providing novel insight into the role of RA in neural networks in humans. PMID: 27120018
  10. mRNAs expression and methylation pattern of RARB, NR4A1 and HSD3B2 genes in human adrenal tissues (HAT) and in pediatric virilizing adrenocortical tumors (VAT) were analyzed. PMID: 27670690
  11. RARb and FHIT promoter methylation may be associated with the carcinogenesis of cervical cancer. FHIT promoter methylation may play a crucial role in cervical cancer progression. Additional studies with large sample sizes are essential to confirm our findings. PMID: 28639889
  12. Upregulation of RARB enhances the sensitivity of cholangiocarcinoma cells to chemotherapeutic agents in vitro. PMID: 27599527
  13. Lack of RARbeta nuclear expression is associated with Non-small cell lung cancer development and associated with a worse prognosis. PMID: 27306217
  14. methylated promoters of DAPK1 combined with MGMT, MGMT combined with RARB, DAPK1 combined with RARB were positive correlated with cervical disease grade PMID: 26823825
  15. Overexpression of miR-146a-5p and miR-146b-5p caused a 31% and 33% decrease in endogenous RARB mRNA levels. PMID: 27011326
  16. shows that RAR-beta methylation detected in lung tissue may be used as a predictive marker for non-small cell lung cancer diagnosis and that APC methylation in tumor sample may be a useful marker PMID: 26681652
  17. RARbeta2 methylation is significantly increased in breast cancer samples when compared to non-cancerous controls PMID: 26451736
  18. Whole-exome sequencing in a South American cohort links ALDH1A3, FOXN1 and RARB/retinoic acid regulation pathways to autism spectrum disorders. PMID: 26352270
  19. Hypermethylation at promoters of RARB, Dietary folate and cobalamin intake is inversely associated with methylated RARB and BRCA1. High dietary intake of riboflavin and pyridoxine is associated with increased methylation in the RARB promoter. PMID: 25805039
  20. Hypermethylation of RARB was associated with esophageal squamous cell carcinoma. PMID: 25514805
  21. Retinoic acid receptor beta and angiopoietin-like protein 1 are involved in the regulation of human androgen biosynthesis PMID: 25970467
  22. Methylated APC and RARbeta2 genes might be valuable serum-based molecular markers for early detection of breast cancer. PMID: 25684670
  23. Curcumin upregulates RARbeta by inhibiting DNMT3b expression which reverses RARbeta promoter methylation. PMID: 25981383
  24. revealed that HSP70 could directly regulate retinoid acid (RA)-induced retinoid acid receptor beta2 (RARbeta2) gene transcription through its binding to chromatin, with R469me1 being essential in this process PMID: 26080448
  25. Methylation of the RAR-beta gene with cigarette smoking is associated with non-small cell lung cancer. PMID: 25605205
  26. Data indicate a differential sensitivity of chondral versus endochondral differentiation pathways to retinoic Acid receptor-Beta (RARbeta) signaling. PMID: 24851851
  27. RAR-beta, whereas ATRA alone had no effect on methylation. The RAR-beta gene was reexpressed following DAC-ATRA combination treatment, and both agents had no effect on p16 expression. PMID: 25413479
  28. in the absence of retinoid signaling via RARbeta, reduced IGF-1 signaling results in suppression of epithelial-mesenchymal transition and delays tumorigenesis induced by the Wnt1 oncogene PMID: 25422594
  29. promoter methylation may play an important role in carcinogenesis of the NSCLC. PMID: 24796328
  30. RARbeta2 circulating DNA in lung cancer patients is at greater methylation rate than in healthy donors. PMID: 25110096
  31. The total frequency of FHIT, RASSF1A and RARbeta gene methylation was significantly higher in lung cancer. PMID: 25040980
  32. Analysis indicates that the genes BIRC5, HOXA1 and RARB are critical targets that play an important regulatory role in cervical cancer pathogenesis. PMID: 25069511
  33. Our meta-analyses identified strong associations of four aberrantly methylated genes (GSTP1, RASSF1, p16, and RARB) with Prostate cancer PMID: 25053593
  34. Results suggest that epigenetic alterations of P16INK4A (p16) and retinoic acid receptor beta (RAR-beta) have an important role in ovarian carcinogenesis. PMID: 24913706
  35. RARB and STMN2 polymorphisms were not associated with sporadic CJD in the Korean population. PMID: 24414001
  36. RARbeta promoter is hypermethylated in all studied prostate tumors and methylation levels are positively correlated with H3K27me3 enrichments. PMID: 24492483
  37. These results highlight the relevance of MSK1 in the up-regulation of RARbeta by prostaglandin E2. PMID: 24953041
  38. The data suggest that RARbeta and p14ARF may be linked in a signaling pathway that is operating in melanocytic cells and is lost in the majority of melanomas. PMID: 23851445
  39. Differences in RAR and RXR subtype mRNA expression patterns in various PTCs may contribute to the immunochemistry data available, and may thus find exploitation in clinical oncology, particularly in the differential diagnosis of thyroid neoplasms PMID: 23969901
  40. Both recessive and dominant mutations in RARB cause anophthalmia. PMID: 24075189
  41. RARbeta2 methylation is associated with the risk of developing prostate cancer. (Meta-analysis) PMID: 23675444
  42. The highest loss of heterozygosity and/or microsatellite imbalance is revealed in RARB locus in non-small cell lung cancer. PMID: 23504373
  43. HHIP, HDAC4, NCR3 and RARB polymorphisms may have a role in impaired lung function that begins in early life PMID: 23456936
  44. All-trans retinoic acid inhibits human scleral fibroblasts proliferation by a mechanism associated with modulation of ERK 1/2 and JNK activation and depends on stimulation of retinoic acid receptor beta. PMID: 23946634
  45. Methylation of the RARB gene increases prostate cancer risk in black Americans. PMID: 23376149
  46. EGFR transactivation by intracellular PGE2-activated EP receptors results in the sequential activation of RARbeta and HIF-1alpha PMID: 23644172
  47. Data show that TLR3 activation by poly I-C induces up-regulation of microRNA-29b, -29c, -148b, and -152 targeting DNA methyltransferases, leading to demethylation and reexpression of the oncosuppressor retinoic acid receptor beta (RARbeta). PMID: 23716670
  48. findings showed that hepatitis C virus Core induced promoter hypermethylation of RAR-beta2 to inhibit its expression; accordingly, Core-expressing cells exhibited resistance to ATRA-induced growth inhibition PMID: 23474497
  49. Second RARbeta2 loss of expression was found associated with different epigenetic profiles in LNCaP and DU145 cells. PMID: 23299856
  50. HIF-1alpha up-regulation is dependent on intracrine PGE2-RARbeta signalling. PMID: 22964004
  51. RARbeta2 and p16(INK4alpha) hypermethylation was significantly related with pathological stage, lymph node metastasis, and invasion of nerves and vessels in patients with esophageal squamous cell carcinoma. PMID: 22967446
  52. Significant correlation was observed between promoter hypermethylation of estrogen receptor beta and RARb2 in tumors and paired sera. Breast cancer patients with RARb2 hypermethylation showed higher recurrence and shorter overall survival. PMID: 22451234
  53. Low RARbeta expression is associated with advanced gastric cancer. PMID: 22901127
  54. Significant correlation was found between alterations of methylation status of miR-9-1, miR-9-3, miR-34b/c, miR-193a and the expression level of RAR-beta2 target gene in the primary lung tumors. PMID: 23156677
  55. In papillary thyroid cancer, significant correlations between the methylation status of the RARbeta2 gene and the V600E BRAF mutation were found. PMID: 22694820
  56. nucleolin plays a coregulatory role in transcriptional regulation of the tumor suppressor RARB2 by COUP-TFII PMID: 22693611
  57. LMP1 overcomes all-trans retinoic acid-induced apoptosis by repressing RAR-b2 expression via DNA methylation. PMID: 22659417
  58. trend toward increasing methylation with severity of cervical squamous intraepithelial lesion cytology PMID: 22116316
  59. Circulating DNA-based testing verifies RARbeta2 methylation level is significantly increased in plasma from patients with non-small cell lung cancer compared with healthy individuals. PMID: 21795979
  60. RARbeta gene promoter methylation and P53 mutation were detected in 58.1% and 36.4% of tumors, respectively. PMID: 22487818
  61. A significant association was observed between urinary retinoic acid receptor-beta2 gene promoter methylation and hyaluronidase activity and advanced grade tumor. PMID: 22286019
  62. The methylation rate of RAR-beta2 in breast cancer and precancerous lesions of breast cancer were higher than that of normal tissues. PMID: 20865461
  63. We investigated the utility of a set of four independent genes (P16, TSHR, RASSF1A and RARbeta2) promoter hypermethylation analysis as a diagnostic or prognostic tool in papillary thyroid tumors PMID: 20535589
  64. Methylated RARbeta(2) and APC genes might be valuable urinary molecular markers for early detection of bilharzial and nonbilharzial bladder cancer. PMID: 21680534
  65. Dietary intakes of folate, vitamins B2, B6, B12, and methionine were not associated with likelihood of promoter methylation of E- cadherin, p16, and RAR-beta2. PMID: 21916701
  66. A significant association between high level of RARB methylation and Gleason score (P=0.01) in prostate cancer PMID: 21822036
  67. Chemotherapy response in esophageal squamous cell carcinoma is much more effective in RAR-beta positive patients than in RAR-beta negative patients. PMID: 21162886
  68. This work demonstrates a dual role for RARB2 tumor suppression and tumor promotion PMID: 21638515
  69. The expression of RAR-beta decreases significantly in cancer tissues in patients with colorectal cancer. Reduced expression is correlated negatively with the lymph node metastasis and advanced clinicopathological stage. PMID: 20302734
  70. Data show that methylation of at least one gene was detected in 18 patients (45%), the genes methylated were CDKN2B (20%), RASSF1 (18%), RARB (10%), CDH13 (7.5%) and FHIT (5%). PMID: 20864173
  71. New insights into the possible effect of some lifestyle-related factors on the aberrant methylation drift of ERalpha and RARbeta2 genes in breast cancer. PMID: 20711807
  72. The p16, DAPK and RAR beta genes methylation are strongly associated with clinical data of non-small cell lung cancer, and methylation of p16 and DAPK genes are associated with tobacco smoking. PMID: 21287504
  73. Data provide evidence that RAR-beta promoter hypermethylation is a major mechanism involved in RAR-beta gene silencing, resulting in impaired RAR-beta function during breast cancer development. PMID: 20505321
  74. hypermethylation in tumors from non-small cell lung cancer patients is associated with gender and histologic type PMID: 19945765
  75. Combined effects of cigarette smoke and hypermethylations of retinoic acid receptor beta are associated with non small cell lung cancer. PMID: 20704749
  76. The higher methylation of RARbeta2 genes in prostate tissue samples from AA in comparison with Cau and may potentially contribute to the racial differences that are observed in prostate cancer pathogenesis. PMID: 20606036
  77. Promoter methylation is responsible for silencing of RAR-beta2 in some melanoma cells and pan-acetylation of H3 likely plays a permissive role in expression of RAR-beta2. PMID: 20374520
  78. Five single nucleotide polymorphism variants in RARbeta were detected in Chinese subjects with high myopia, none of them were associated significantly with high myopia. PMID: 20508731
  79. HIN-1, RAR-beta, RASSF1A, and Twist had the ability to distinguish high-grade squamous intraepithelial lesions/squamous cell carcinomas from low-grade squamous intraepithelial lesions/negative cervical scrapings PMID: 20496080
  80. DNA hypermethylation of RARbeta2 is associated with inflammatory breast cancer. PMID: 19829046
  81. RARbeta and MGMT genes were found to be more frequently methylated in 70.58% and 58.8% of glioblastomas, respectively. PMID: 19809523
  82. HBx induced promoter hypermethylation of RARbeta2, resulting in downregulation of its expression in hepatocellular carcinoma cells. PMID: 19828754
  83. RAR-beta2 mRNAs increase signs the normal differentiation of the human bronchial epithelium while a decrease is observed in most lung cancer cell lines PMID: 19961602
  84. Findings suggested that aberrant methylation of RARbeta2 occurs frequently in Tunisian breast cancer patients compared with others. PMID: 19657672
  85. Data show that methylation of CCND-2, p16, RAR-beta and RASSF-1a was significantly more prevalent in tumor than in normal tissue specimens. PMID: 19618401
  86. Promoter hypermethylation was observed in PRB 67%, ERalpha 64%, RASSF1A 63%, p16INK4A 51%, RARbeta2 22%, GSTP1 25% and BRCA1 27% of the breast cancers, respectively. PMID: 19940364
  87. The expression of exogenous hRAR beta gene in HL-60R cells could resume their sensitivity to retionoids in inhibiting cell proliferation and inducing granulocytic differentiation. PMID: 11769677
  88. PML-RAR fusion protein induces gene hypermethylation and silencing by recruiting DNA methyltransferases to the RARbeta2 promoter PMID: 11834837
  89. distinct methylation pattern in bladder cancer with frequent methylation of RARbeta, DAPK, E-cadherin, and p16. PMID: 11839665
  90. Results indicate that loss of RAR-beta expression and accumulation of p 53 and Ki67 proteins may serve as biomarkers for early identification of esophageal cancer in the high-risk populations. PMID: 11925591
  91. Methylation of the 5' region of RAR-beta 2 gene may contribute to gene silencing and may be an important and early event in cervical carcinogenesis. PMID: 11945179
  92. Endogenous reactivation of the RARbeta2 tumor suppressor gene epigenetically silenced in breast cancer. PMID: 11980632
  93. downstream codons in mRNAs initiate translation of a protein isoform that disrupts retinoid-activated transcription PMID: 12118004
  94. Loss of retinoic acid receptor beta gene expression is linked to aberrant histone H3 acetylation in lung cancer cell lines. PMID: 12124324
  95. STAT-1, IRF-1, and RAR-beta expression were enhanced by IFN-gamma and ATRA in combination, and to a greater degree in BALM-3 cells than in BALM-1 cells, suggesting that these IFN-gamma related genes were involved in the induction of apoptosis. PMID: 12191570
  96. Present only in basal epithelial nuclei. RAR-beta and -gamma were increased in basal and luminal epithelial nuclei in glands with benign prostatic hyperplasia. PMID: 12399530
  97. RARbeta expression may be an indicator of increased risk of lung cancer in heavy smokers. PMID: 12529350
  98. RARbeta and RARgamma interact only weakly with SMRT. PMID: 12554770
  99. results suggest that oxidized phospholipids inhibit transcription of the thrombomodulin gene in vascular endothelium by inhibiting the binding of retinoic acid receptor beta-retinoid x receptor alpha heterodimer and Sp1 and Sp3 to thrombomodulin promoter PMID: 12576329
  100. ATRA increased RARbeta2 mRNA in non-metastatic breast cancer cells. The same treatment of metastatic cells resulted in an increase in RARbeta4 & a decrease in RARbeta2 mRNA. RARbeta4 may contribute to metastatic properties of breast cancer cell lines. PMID: 12579317

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Involvement in disease Microphthalmia, syndromic, 12 (MCOPS12)
Subcellular Location Isoform Beta-1: Nucleus, SUBCELLULAR LOCATION: Isoform Beta-2: Nucleus, SUBCELLULAR LOCATION: Isoform Beta-4: Cytoplasm
Protein Families Nuclear hormone receptor family, NR1 subfamily
Database Links

HGNC: 9865

OMIM: 180220

KEGG: hsa:5915

STRING: 9606.ENSP00000332296

UniGene: Hs.543218

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