Recombinant Human Short transient receptor potential channel 3 (TRPC3), partial

1. Diacylglycerol generation downstream of VEGF receptors activatesTRPC3 causing Na(+) influx with subsequent reversal of NCX1, ERK1/2 activation and ultimately contributes to enhanced angiogenesis. PMID: 28535874
2. TRPC3contributes to melanoma proliferation and migration through activation of STAT5/Akt signaling. PMID: 27613608
3. We also observed that acetylcholine attenuated the formation of NCX1-TRPC3-IP3R1 complexes and maintained calcium homeostasis in cells treated with TNF-alpha. PMID: 28395930
4. Data show clear inhibition of the photouncaging- induced Ca2+ signal by the TRPC3 channel inhibitor SKF 96365. PMID: 27430887
5. The subsequent ER stress-induced apoptosis exhibit a strong requirement for constitutive Ca(2+) influx and that TRPC3 contributes to this process. PMID: 26215710
6. Data show that mechanical stretching of transient receptor potential cation channel, subfamily C, member 3 (TRPC3) overexpressing fibroblasts induced the activation of nuclear factor-kappa B (NFkappaB). PMID: 26108359
7. TRPC3 and TRPC6 participate diversely in synaptic reorganization in the mossy fiber pathway in temporal lobe epilepsy. PMID: 25213992
8. the first in vivo evidence for a proatherogenic role of endothelial TRPC3. PMID: 25870279
9. CaSR activation mediates Ca2+ influx and cell proliferation via TRPC3 and TRPC6 in human mesangial cells PMID: 24905090
10. although gene deletion of TRPC3 or TRPC6 alone did not protect against hypertrophy or dysfunction from pressure overload, combined deletion was protective, supporting the value of dual inhibition PMID: 24453217
11. there is an absolute requirement for TRPC3-mediated diacylglycerol-dependent Ca(2+) entry to initiate and sustain the spiking response. PMID: 23682725
12. Removal of a large hydrophobic residue (I667A or I667E) generated TRPC3 channels with approximately 60% constitutive activity, suggesting I667 as part of the dynamic structure occluding the permeation path. PMID: 23800762
13. These data emphasize the role of TRPC3 and Ca(2+) influx in the regulation of BDNF secretion by human airway smooth muscle. PMID: 23899746
14. Higher TRPC3 expression levels correlated with early relapse and worse prognosis in ovarian cancer, and TRPC3 plays a significant role in the stimulating activity of FSH. PMID: 23580589
15. Pdx-1 activates islet alpha- and beta-cell proliferation via a mechanism regulated by transient receptor potential cation channels 3 and 6 and extracellular signal-regulated kinases 1 and 2. PMID: 23938296
16. A significant fraction of mitochondrial divalent calcium (Ca2+) uptake that relies on extramitochondrial Ca2+ concentration is TRPC3-dependent, and the up- and down-regulation of cell TRPC3 expression influences the mitochondrial membrane potential. PMID: 23776229
17. study suggests that TRPC3 may be a potential new target in endothelial protection in patients with endothelial dysfunction such as in patients with coronary artery disease PMID: 22960861
18. Results indicate that oleic acid can influence T-lymphocyte functions, in the conjugated form of diacylglycerol (DAG) via opening transient receptor potential cation channel subfamily C TRPC3/6 channels. PMID: 22306362
19. In the presence of 2-APB or after siRNA knockdown of TRPC3 the fMLP-induced monocyte migration was significantly blocked in hypertensive patients compared to normotensive control subjects. PMID: 22438881
20. Calcium metabolism abnormalities observed in Williams-Beuren syndrome may be attributable to transcription factor IIi gene haploinsufficiency and subsequent TRPC3 overexpression. PMID: 22566418
21. Data show the expression of TRPC6 and TRPV1 was significantly increased after 24 hours of exposure to an atheroprone flow, whereas the expression of TRPC3 and TRPM7 was significantly higher in endothelial cells exposed to shear stress. PMID: 22566504
22. The TRPC3 alternative promoter is a methylation quantitative-trait locus associated with the ataxia phenotype. PMID: 21931279
23. We find that in Purkinje cells, activation of TRPC3-dependent currents is not inhibited by conventional PKC or PKG to any significant extent and that inhibition of these kinases does not significantly impact on TRPC3-mediated currents either. PMID: 22207762
24. TRPC3 expression is associated with hypertension and hypoxic conditions in human cerebral vascular tissue. PMID: 21957871
25. Higher levels of TRPC3 expression is associated with treatment response in lung adenocarcinoma. PMID: 21603869
26. Our findings suggest that mutations in TRPC3 do not significantly contribute to the cause of late-onset and episodic human cerebellar ataxias PMID: 21321808
27. There is a significant increase of TRPC3 channel protein expression in patients with chronic kidney disease compared to healthy control subjects (normalized expression, 0.42+/-0.06 vs. 0.19+/-0.03; p<0.01). PMID: 21802402
28. analysis of the role of specific domains in the different responsiveness of TRPC3 and TRPC6 to erythropoietin PMID: 21757714
29. A central role is demonstrated for sodium entry via TRPC3/6 channels via receptor-mediated increases in intracellular calcium. PMID: 20728215
30. TRPC3 modulates Ca(2)+-dependent proliferation of primary CD4+ T-cells indicating that TRPC3 may be involved in Ca(2)+ homeostasis in T cells. PMID: 21215279
31. TRPC3 functions as both a Ca(2+)-permeable channel and a protein scaffold at the plasma membrane for downstream PKCbeta activation in B cells. PMID: 20179100
32. On TRPC3 constitutive function through a signaling mechanism that requires constitutive TRPC3-mediated Ca2+ influx for activation of nuclear factor kappaB, presumably through Ca2+-dependent activation of the calmodulin/calmodulin-dependent kinase. PMID: 20360250
33. plays pivotal roles in the process of astrocytic and microglial activation. PMID: 20190511
34. Since it activates calcium signaling and induce cardiac hypertrophy, it may be a new therapeutic target for heart failure. PMID: 20190513
35. controls Ca(2+) influxes that induce diverse cellular processes and its selective inhibitor Pyr3 is useful for treatments of the diseases mediated by it. PMID: 20190514
36. Comparison of human TRPC3 channels in receptor-activated and store-operated modes. PMID: 11943785
37. receptor-mediated activation of phospholipase C in intact cells activates TRPC3 via diacylglycerol production. PMID: 12606542
38. overexpression of transient receptor potential channel 3 in myometrium cells enhanced thapsigargin-, oxytocin-, and OAG-induced Ca2+ entry PMID: 12700192
39. the CIRB region of TRPC3 is involved in its targeting to the plasma membrane by a mechanism that does not involve interaction with IP3 receptors PMID: 12730194
40. TRPC3 channels are important for the TCR-dependent Ca2+ entry pathway. The TRPC3 gene was found to be damaged in human T-cell mutants defective in Ca2+ influx. PMID: 12736256
41. the pattern of TRPC3 and TRPC6 glycosylation determines regulation of their activity PMID: 12970363
42. functional and physical interaction of nonselective TRPC cation channels with NCX proteins as a novel principle of TRPC-mediated Ca(2+) signaling. PMID: 14736881
43. TRPC3 channels are directly phosphorylated by PKG at position T11 and S263, and this phosphorylation abolished the store-operated Ca2+ influx mediated by TRPC3 channels in HEK293 cells. PMID: 14983059
44. diacylglycerol activation of TRPC3 requires src kinase PMID: 15271991
45. TRPC channel overexpression may be partially responsible for the increased pulmonary artert smooth muscle cell proliferation and pulmonary vascular medial hypertrophy in pulmonary hypertension patients. PMID: 15358862
46. a strong functional link between the operation of expressed TRPC channels and endogenous SOC activity. PMID: 15647288
47. the partial PH domain of PLC-gamma1 interacts with a complementary partial PH-like domain in TRPC3 to elicit lipid binding and cell-surface expression of TRPC3 PMID: 15744307
48. Protein kinase C can inactivate TRPC3 indirectly by activating protein kinase G, and directly by phosphorylation on Ser-712. PMID: 16331690
49. Cholesterol loading as well as PLC stimulation increased surface expression of TRPC3. Promotion of TRPC3 membrane expression by cholesterol was persistent, while PLC-mediated enhancement of plasma membrane expression of TRPC3 was transient. PMID: 16448384
50. expression of TRPC3 is tightly regulated during muscle cell differentiation and functional interaction between TRPC3 and RyR1 may regulate the gain of SR Ca(2+) release independent of SR Ca(2+) load PMID: 16484216

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HGNC: 12335

OMIM: 602345

KEGG: hsa:7222

STRING: 9606.ENSP00000368966

UniGene: Hs.150981