Recombinant Human Transmembrane channel-like protein 6 (TMC6), partial

Code CSB-YP768764HU
MSDS
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Source Yeast
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Code CSB-EP768764HU
MSDS
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Source E.coli
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Code CSB-EP768764HU-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP768764HU
MSDS
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Source Baculovirus
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Code CSB-MP768764HU
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
TMC6
Uniprot No.
Alternative Names
TMC6; EVER1; EVIN1Transmembrane channel-like protein 6; Epidermodysplasia verruciformis protein 1; Protein LAK-4
Species
Homo sapiens (Human)
Protein Length
Partial
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
Probable ion channel.
Gene References into Functions
  1. The present study did not show any significant association of the EVER1/2 polymorphisms (rs2290907and rs16970849) with cervical cancer. PMID: 27899077
  2. There were no differences in Ever1 SNPs between head and neck squamous cell carcinoma patients with human papilloma virus (HPV)-positive and HPV-negative tumors, and healthy controls. PMID: 27097911
  3. Findings suggest that SNP in EVER 1 may be involved in the development of premalignant skin lesions that harbour beta-HPV, perhaps giving rise to SCC tumours that have lost beta-HPV gene expression during progression PMID: 26126409
  4. TMC6/EVER1 and TMC8/EVER2 are known to be involved in the development of EV. PMID: 26227733
  5. TMC6 variants are associated with diminished age-of-onset of P. aeruginosa airway infection in children with cystic fibrosis. PMID: 26047157
  6. EV is also a rare autosomal recessive genodermatosis involving susceptibility to human papillomavirus (HPV) infections and squamous cell carcinoma, caused in most cases by homozygous mutations in EVER1 or EVER2. PMID: 23534907
  7. Expression of both EVER1 and EVER2 in B cells is activated immediately after Epstein-Barr virus (EBV) infection, whereas at later stages, it is strongly repressed by latent membrane protein 1-activated NF-kappaB signaling. PMID: 25378492
  8. We report a case of Merkel cell polyomavirus detection in the skin of a patient with epidermodysplasia verruciformis (EDV) and a family history remarkable for an unusual inheritance pattern for EDV. PMID: 23535066
  9. EVER proteins appear as key components of the activation-dependent regulation of Zn(2+) concentration in T cells. However, the impact of EVER-deficiency in T cells on EV pathogenesis remains to be elucidated PMID: 22761942
  10. Data support the involvement of the TMC6/8 region in cervix cancer susceptibility. PMID: 21387292
  11. Mutations in EVER1 are associated with epidermodysplasia verruciformis. PMID: 12426567
  12. Nonsense mutations of EVER1gene is associated with epidermodysplasia verruciformis PMID: 15042430
  13. four mutations in recurrent respiratory papillomatosis patients might indicate that EVER 1 alleles are not associated with susceptibility to RRP PMID: 16487602
  14. The growing number of mutations in epidermodysplasia verruciformis (EV) pedigrees supports the hypothesis that EVER1 and EVER2 are the molecular basis of EV. PMID: 17008061
  15. HPV16 E5 protein binds to EVER and ZnT-1 and blocks their negative regulation PMID: 18158319
  16. epidermodysplasia verruciformis in a father and a son with typical histologic and clinical findings that occur in the absence of mutations in EVER1 PMID: 19706093

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Involvement in disease
Epidermodysplasia verruciformis (EV)
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein.
Protein Families
TMC family
Tissue Specificity
Expressed in placenta, prostate, testis, activated T-lymphocytes and lymphokine-activated killer (LAK) lymphocytes.
Database Links

HGNC: 18021

OMIM: 226400

KEGG: hsa:11322

STRING: 9606.ENSP00000313408

UniGene: Hs.632227

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