Recombinant Mouse A-kinase anchor protein 5 (Akap5)

1. AKAP150 regulates Ca(2+ )cycling and myocardial ionotropy following pathological stress, promoting pathological remodelling and heart failure propensity. PMID: 27856611
2. AKAP150-calcineurin signaling dyad is essential for the activation of the phosphatase and the subsequent down-regulation of Kv channel currents following myocardial infarction. PMID: 26724383
3. This study demonstrated that the AKAP150 oordinates metabotropic glutamate receptor sensitization of peripheral sensory neurons. PMID: 26172554
4. Thus, our present study revealed that AKAP5 plays a significant role in the regulation of sympathetic nerve activities. PMID: 26713362
5. Identify a novel cardioprotective role for AKAP5 that is mediated by regulating the activities of cardiac CaN and CaMKII and highlight a significant role for cardiac beta-ARs in this phenomenon. PMID: 25225170
6. endothelial-dependent dilation of resistance arteries is enabled by MEP-localized AKAP150, which ensures the proximity of PKC to TRPV4 channels and the coupled channel gating necessary for efficient communication from endothelial to smooth muscle cells PMID: 25005230
7. Our results support a model whereby subcellular anchoring of CaN by AKAP150 is a key molecular determinant of vascular BKCa channel remodeling, which contributes to vasoconstriction during diabetes mellitus. PMID: 24323672
8. a significant role for the AKAP5 scaffold in signaling and trafficking of the beta1-AR in cardiac myocytes and mammalian cells. PMID: 24121510
9. Anchoring of protein kinase A and adenylyl cyclase by AKAP5 is important for regulation of postsynaptic functions and specifically AMPA receptor activity. PMID: 23649627
10. AKAP150 null mice secrete less insulin yet have better glucose handling due to increased insulin sensitivity in target tissues. Tethering of phosphatases to a seven-residue sequence of Akap5 is the main molecular event for this. PMID: 22940692
11. This study demonistrated taht AKAP79/150-anchored CaN in regulation of Ca2+-permeable GluA1 homomers that our results here now clearly establish as a key mechanism that maintains bidirectional synaptic plasticity in the hippocampus. PMID: 23100425
12. A kinase anchor protein 150 (AKAP150)-associated protein kinase A limits dendritic spine density PMID: 21652711
13. We propose that AKAP150-dependent changes in Ca(V)1.2-LQT8 channel gating may constitute a novel general mechanism for Ca(V)1.2-driven arrhythmias. PMID: 21700933
14. other neural AKAPs cannot compensate for the loss of PKA binding to AKAP5 PMID: 20428246
15. In knockout AKAP5 cardiomyocytes, beta-adrenergic regulation of calcium transients is disrupted. PMID: 20671242
16. Study reveals that non-neurotransmitter Abeta has a binding capacity to beta(2)AR and induces PKA-dependent hyperactivity in AMPA receptors. PMID: 20395454
17. These data suggest that isoproterenol-stimulated amylase secretion occurs via both an AKAP5/AC6/PKA complex and a PKA-independent, Epac pathway in mouse parotid acini. PMID: 20164376
18. An important role of AKAP150 in coordinating signaling events regulating the frequency of intrinsic pulsatile GnRH secretion. PMID: 19887564
19. CaMKIIalpha targets a specific SAP97 splice variant to disengage AKAP79/150 from regulating GluR1 AMPARs PMID: 19858198
20. The association of AKAP150 with TREK channels integrates them into a postsynaptic scaffold where both G-protein-coupled membrane receptors and TREK-1 dock simultaneously. PMID: 17110924
21. AKAP150 protein levels were increased upon exposing mice to the novel context independent of the training protocol. After habituation, only mice that learned to associate the context with the footshock showed an upregulation of AKAP150. PMID: 17270471
22. AKAP150-anchored PKA might critically contribute to LTP in adult hippocampus in part by phosphorylating GluR1 to foster postsynaptic accumulation of homomeric GluR1 AMPA receptors during initial LTP in 8-week-old mice PMID: 17972919
23. local control of L-type Ca2+ channel function is regulated by AKAP150-targeted protein kinase C signaling, which controls stuttering persistent Ca2+ influx, vascular tone, and blood pressure and underlies angiotensin II-dependent hypertension. PMID: 18174462
24. temporal and spatial compartmentalization of hippocampal PKA signaling pathways, as achieved by anchoring of PKA to AKAPs, is specifically instrumental in long-term contextual fear memory consolidation and extinction, but not in acquisition and retrieval PMID: 18442935
25. data indicate that AKAP150-anchored protein kinase A activity is required to induce long-term depression and not merely to maintain a tonically heightened activity level of AMPA receptors as proposed earlier PMID: 18617570
26. distinct AKAP150-enzyme complexes regulate context-dependent neuronal signaling events PMID: 18711127

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KEGG: mmu:238276

STRING: 10090.ENSMUSP00000114495

UniGene: Mm.311452