Recombinant Mouse Aldehyde dehydrogenase, mitochondrial (Aldh2)

1. data revealed that ALDH2 enzyme may suppress myocardial autophagy possibly through a complex JNK-Bcl-2 and IKKbeta-AMPK-dependent mechanism en route to accentuation of myocardial remodeling and contractile dysfunction in aging. PMID: 28347844
2. results thus suggest that ALDH2 is indispensable for the favorable cardiac effect of low-to-moderate alcohol consumption and ALDH2 deficiency may lead to unexpected cardiac dysfunctions via enhancing myocardial apoptosis and necroptosis. PMID: 27840306
3. ALDH2 activation improved ethanol-induced cardiac damage and decreased angiotensin and angiotensin II in hearts. PMID: 29506687
4. ALDH2 overexpression inhibited the expression of c-Jun N-terminal kinase (JNK)-1, activated protein 1 (AP-1), insulin receptor substrate 1 (IRS-1), 4- hydroxynonenal, caspase 3, transforming growth factor beta1, and collagen I and III, and enhanced Akt phosphorylation. PMID: 30092566
5. Study found ALDH2*2 diabetic mice exhibit diastolic dysfunction and preserved systolic function at rest, similar to clinical heart failure of preserved ejection fraction. PMID: 29677191
6. ALDH2 deficiency reduced the therapeutic effect of ALDHbr cells in the mice model of ischemic hind limb due to decreased anaerobic glycolysis and increased mitochondrial ROS generation. PMID: 28582728
7. osteoblast differentiation is impaired in the absence of Aldh2 gene. PMID: 28474171
8. ALDH2 plays a protective role in cyclophosphamide-induced acute hepatotoxicity via attenuating oxidative stress and detoxifying reactive aldehydes. PMID: 29524404
9. Deficiency in ALDH2 activity may contribute to increased cisplatin sensitivity and cytotoxicity by producing more ROS by the treatment. PMID: 28532411
10. our data suggest that ALDH2 serves as an indispensable cardioprotective factor against insulin resistance-induced cardiomyopathy with a mechanism possibly associated with facilitation of the Sirt3-dependent PGC-1alpha deacetylation. PMID: 27634872
11. Findings suggested that ALDH2 can influence atherosclerotic plaque development and vulnerability, and inflammation via MAPK, NF-kappaB and AP-1 signaling pathways. PMID: 27191745
12. ALDH2 deficiency triggers decompensation of metabolic reserves and energy metabolism disturbances in early diabetic hearts. PMID: 27488451
13. Results show that ALDH2 is required for a normal adipogenesis and its expression in white adipose tissue is negatively correlated with obesity. Also, the study provides evidence that PKCepsilon-ALDH2 pathway positively regulates adipocyte differentiation by regulation of PPARgamma transcriptional activity. PMID: 27575855
14. In knock-in mice in which ALDH2 enzymatic activity is maximally reduced, cardio-protection in ischemic-reperfused hearts is lacking. PMID: 28500264
15. Mitochondrial aldehyde dehydrogenase 2 (ALDH2) overexpression attenuates exhaustive exercise-induced mitochondrial oxidative stress PMID: 28249782
16. ALDH2-catalyzed NO formation is necessary and sufficient for nitroglycerin bioactivation in vascular smooth muscle cells. PMID: 27679490
17. capable of modulating the aggressive, highly metastatic phenotype of hepatocellular carcinomas in vivo PMID: 28027570
18. prolonged treatment of apoE(-/-) mice with Alda-1 led to the beneficial changes in the expression of genes and proteins related to neuroplasticity and mitochondrial function. PMID: 28218653
19. ALDH2 activation is adequate to improve the autophagy flux by reducing the carbonyl modification on SIRT1, which in turn plays an important role in maintaining cardiac health during aging. PMID: 26741505
20. Our findings provide new insight into the preventive role of oesophageal ALDH2 against acetaldehyde-derived DNA damage. PMID: 26374466
21. High concentrations of ETBE might result in reproductive toxicity in mice with normal active ALDH2, while low active/inactive ALDH2 significantly enhanced the ETBE-induced reproductive toxicity in mice. PMID: 24448831
22. ALDH2 deficiency enhances ethanol-induced disruption of intestinal epithelial tight junctions. PMID: 26173414
23. In mice lacking ALDH2, there would be increases in 4-hydroxynonenal and the appearance of Alzheimer's disease-like pathological changes. PMID: 25910195
24. Mitochondrial aldehyde dehydrogenase 2 plays protective roles in heart failure after myocardial infarction via suppression of the cytosolic JNK/p53 pathway in mice. PMID: 25237043
25. ALDH2 functions as a tumor suppressor by maintaining genomic stability in the liver, and the common human ALDH2 variant would present a significant risk factor for hepatocarcinogenesis. PMID: 26150517
26. ALDH2 activation, Alda-1, inhibited atherosclerosis and attenuated NAFLD in apoE(-/-) mice. PMID: 25392542
27. Findings suggest that miR-28 promotes myocardial ischemia through the inhibition of ALDH2 expression in mus. PMID: 25807426
28. Rutin increased ALDH2 expression, while daidzin reversed this beneficial effect. Thus, this study demonstrates rutin protects HT22 cells against ethanol-induced neurotoxicity by increasing ALDH2 activity. PMID: 25084483
29. Alda-89 reduced acetaldehyde-induced behavioral impairment by causing a rapid reduction in blood ethanol and acetaldehyde levels after acute ethanol intoxication in both wild-type and ALDH2-deficient, ALDH2*1/*2, heterozygotic knock-in mice PMID: 25713355
30. the mitochondrial enzyme ALDH2 regulates nociception. PMID: 25163478
31. ALDH2 deficiency exacerbates the pressure overload induced cardiac dysfunction partly by inhibiting Beclin-1 dependent autophagy pathway. PMID: 25086229
32. ALDH2 protects against diabetes-induced myocardial dysfunction possibly through an AMPK -dependent regulation of autophagy. PMID: 24874076
33. ALDH2 deficiency aggravates low to moderate alcohol-induced serum ethanol and acetaldehyde accumulation. PMID: 24998256
34. The present study demonstrates that ALDH2 plays a crucial role in maintaining normal mitochondrial function to protect against rotenone-induced neurotoxicity PMID: 25263579
35. ALDH2 enzyme may aggravate myocardial remodeling and contractile dysfunction in aging, possibly through AMPK/Sirt1-mediated mitochondrial injury. PMID: 24675227
36. ALDH2(-/-) mice are resistant to ethanol-induced steatosis but prone to inflammation and fibrosis by way of malondialdehyde acetaldehyde adduct-mediated paracrine activation of IL-6 in Kupffer cells. PMID: 24492981
37. Results show that disruption of aldh2 gene resulted in altered cortical bone structure and dynamics in mice. PMID: 23313283
38. ALDH1A3 and ALDH2 expression was detectable in ALDH(very-br) and ALDH(br) cells, unlike ALDH(dim) cells, albeit at lower levels compared with ALDH1A1 and ALDH1A2. PMID: 23484127
39. A dominant-negative form of aldehyde dehydrogenase 2 (ALDH2) protein, ALDH2*2, which is produced by a single nucleotide polymorphism (rs671), promotes osteoporosis due to impaired osteoblastogenesis. PMID: 22508505
40. The protective role of ALDH2 against ER stress-induced cell death was probably mediated by Akt via a p47(phox) NADPH oxidase-dependent manner. These findings indicate the critical role of ALDH2 in the pathogenesis of ER stress in heart disease. PMID: 22430940
41. analysis of neurodegeneration and motor dysfunction in mice lacking cytosolic and mitochondrial aldehyde dehydrogenases PMID: 22384032
42. Aldehyde dehydrogenase 2 deficiency may directly contribute to excess acetaldehyde (AcH) accumulation after ethanol (EtOH) drinking and AcH mediates some of the behavioral effects of EtOH. PMID: 22361447
43. ALDH2 acted against diabetes-induced cardiac contractile and intracellular Ca2+ dysregulation, possibly through regulation of apoptosis, glycogen synthase kinase-3beta activation and mitochondrial function independent of the global metabolic profile. PMID: 22524197
44. The results suggest that ALDH2 protects against ethanol toxicity through altered Akt and AMPK signaling and regulation of autophagic flux. PMID: 21871561
45. Alcohol consumption suppressed the differentiation and mineralization of osteoblasts, reduced trabecular bone formation and bone volume in association with the elevated p21 expression in bone marrow cells, in aldehyde dehydrogenase 2-disrupted mice. PMID: 21256255
46. ROS generation by AngII may be decreased by ALDH2, thereby preventing ROS-induced vascular contraction. PMID: 21459068
47. aldehyde dehydrogenase 2 (ALDH2) activation confers cardioprotection in protein kinase C epsilon (PKCvarepsilon) knockout mice PMID: 19913552
48. These results suggested that ALDH2 deficiency led to worsened ethanol-induced cardiomyocyte function, possibly due to upregulated expression of protein phosphatase, depressed Akt activation, and subsequently impaired mitochondrial function. PMID: 20362583
49. ethanol and acetaldehyde treatment affects Aldh2 knockout mice more than wild type mice. PMID: 19874182
50. mitochondrial ALDH2 functions as a protector against oxidative stress PMID: 12603834

Show More

Hide All

KEGG: mmu:11669

STRING: 10090.ENSMUSP00000031411

UniGene: Mm.284446