Recombinant Mouse Aldose reductase (Akr1b1)

1. modulation of macrophage metabolism by inhibition of AR might represent a novel strategy to modulate host defense responses and to modify metabolism to promote macrophage hypertrophy and phagocytosis under inflammatory conditions PMID: 28111134
2. Aldose reductase acts as a switch which can regulate microglia by polarizing cells after spinal cord injury. PMID: 25520004
3. AR overexpression elevates retinal microglia activation in retina. PMID: 27033597
4. Aldose reductase contributes to diabetes-mediated mitochondrial dysfunction and damage through the activation of p53. PMID: 24474649
5. Data indicate that inhibition of AR alleviates the MCD diet-induced liver inflammation and fibrosis in db/db mice, probably through dampening CYP2E1 mediated-oxidative stress and ameliorating the expression of pro-inflammatory cytokines. PMID: 24066058
6. FMHM suppressed the activity of AR-dependent phospholipase C/protein kinase C signaling, which further resulted in downstream inactivation of the IkappaB kinase/IkappaB/nuclear factor-kappa B inflammatory pathway. PMID: 24021941
7. AR is a critical regulator of protein carnosinylation and carnosine-mediated tissue protection PMID: 23928303
8. Allergen-induced airway remodeling is mediated by AR and its inhibition blocks the progression of remodeling via inhibiting TGFbeta1-induced Smad-independent and PI3K/AKT/GSK3beta-dependent pathway. PMID: 23460857
9. BGG-mediated inhibition of aldose reductase prevented LPS-induced activation of JNK. PMID: 23247009
10. Activation of AR in podocytes may be implicated in diabetic podocytopathy. PMID: 22253613
11. crystal of AKR1B3 was tetragonal, belonging to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 107.62, c = 120.76 A PMID: 22139184
12. the role of AKR1B3 in regulating advanced glycosylation end products and advanced lipoxidation end products PMID: 21276777
13. Genetic deficiency of Ar significantly ameliorated development of key endpoints linked with early diabetic nephropathy in vivo. PMID: 21267539
14. a Y48F/H110F double mutant of AKR1B3 completely lost PGDS activity and showed only 2.9% of PGFS activity PMID: 21306562
15. Sequential catalysis of Aldr1 by glutathione S-transferase P and glutaredoxin may be a general redox switching mechanism that regulates the reduction of protein sulfenic acids to cysteines regulates the reduction of protein sulfenic acids to cysteines PMID: 20538586
16. regulates LPS-induced glucose uptake and expression of glucose transporter-3 in macrophages PMID: 20348015
17. The present study indicates that inhibition of aldose reductase in diabetics may protect against damage in the brain and retina following ischemic reperfusion injury. PMID: 20143423
18. These results indicate that AR plays an important role in diabetes-associated impaired nerve regeneration, in part by affecting vascularization and macrophage invasion during Wallerian degeneration. PMID: 20142761
19. AKR1B3 acts as the PGFS in adipocytes and AKR1B3-produced PGF(2alpha) suppresses adipocyte differentiation by acting through FP receptors PMID: 20093363
20. Nrf2 protein regulated the AKR1B3 promoter activity via antioxidant response elements (ARE1) and the activator protein 1 site (AP1). PMID: 15655294
21. The role of AR in the pathogenesis of diabetic retinopathy was studied in mice with an AR null mutation. PMID: 16249434
22. Aldose reductase not only plays important roles in osmoregulation and medullary cell survival but may also be essential for the full maturation of the urine concentrating mechanism. PMID: 16449351
23. Increased polyol pathway flux through AR is a major contributing factor in the early signs of diabetic neuropathy, possibly through depletion of glutathione, increased superoxide accumulation, increased jn terminal kinase activation, and DNA damage. PMID: 16804062
24. reduced glutathionyl-4-hydroxynonanal-lipid aldehydes catalyzed by AR propagate lipopolysaccharide-induced production of inflammatory markers PMID: 16956889
25. Aldose reductase mediates endotoxin-induced inflammation and cardiomyopathy PMID: 17030682
26. Catalyzes lipid aldehyde-glutathione conjugates regulate the lipopolysacchaide-induced production of inflammatory marker nitric oxide and cytotoxicity in RAW 264.7 macrophage cells. PMID: 17382209
27. AR plays an important role in the regulation of hepatic PPARalpha phosphorylation and activity and lipid homeostasis PMID: 18445591
28. EGFR-Ras-MAPK pathway contributes to TonEBP transcriptional activation and targets gene expression during osmotic stress, thus establishing a membrane-associated signal input that contributes to the regulation of TonEBP activity PMID: 19225051
29. Aldose reductase protects against early atherosclerotic lesion formation in apolipoprotein E-null mice. PMID: 19729598
30. Inhibition of aldose reductase prevents oxidant-induced inflammatory signals leading to cytotoxicity in small airway epithelial cells and ovalbumin-induced airway inflammation in mice. PMID: 19752229

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KEGG: mmu:11677

STRING: 10090.ENSMUSP00000100045

UniGene: Mm.389126