Recombinant Mouse Alpha-ketoglutarate-dependent dioxygenase FTO (Fto)

1. In C57bl/6 model, glycaemic index of maternal dietary carbohydrates differentially alters Fto and Lep expression in offspring. PMID: 30241328
2. Mutations in genes implicated in body mass and timing of puberty in the general population may contribute to the pathogenesis of self-limited delayed puberty. Fto+/- mice displayed a significantly delayed timing of pubertal onset as well. PMID: 29161441
3. FTO demethylase activity is essential for normal bone development and mineralization, a previously unreported FTO function. PMID: 29203346
4. FTO is critically involved in insulin defects-related Alzheimer's disease. PMID: 29501742
5. This is the first study revealing the presence of a parallel increase in expressions of FTO and HNRNPK proteins. This increase may codictate the metabolic changes occurring in the cell and may attribute a significance to HNRNPK in FTO-associated transformations. PMID: 28555196
6. Contextual fear conditioning decreased FTO levels in neurons from the hippocampus. PMID: 28205605
7. The involvement of mTOR-PGC-1alpha pathway in the connection between FTO and muscle differentiation is displayed. PMID: 28333151
8. In vivo experiments revealed that Fto(-/-) and Fto(+/-) mice were more susceptible to thiopurine-induced myelosuppression than wild-type mice. PMID: 27558924
9. propose that PKCbeta acts to suppress the degradation of FTO protein and reveals the associated role of PKCbeta and FTO in adipogenesis, suggesting a new pathway that affects the development of obesity and metabolic diseases PMID: 28626026
10. the results of this study indicate that the effects of FTO-associated SNPs on energy homeostasis are due in part to the effects of these genetic variations on hypothalamic FTO, RPGRIP1L, and possibly other genes. PMID: 27064284
11. FTO may have a deleterious role in hepatic cells during lipotoxic conditions, and up-regulation of FTO may contribute to the increased liver damage in non-alcoholic steatohepatitis PMID: 27651333
12. Fto deficiency affects the gene and miR130/miR378 expression involved in brown adipogenesis and browning of white adipose tissue in mice. PMID: 27827997
13. Here we show that FTO expression is increased after ureteral obstruction and renal fibrosis. PMID: 26727661
14. Taken together, the results suggest that Fto regulates the proliferation and differentiation of 3T3-L1 cells via multiple mechanisms, including PPARgamma and PI3K/Akt signaling. PMID: 26907332
15. These results reveal that FTO regulates fatty acid mobilization in adipocytes and thus body weight in part through posttranscriptional regulation of Angptl4. PMID: 26671148
16. FTO-dependent N6-methyladenosine demethylation may be affected by betaine. PMID: 26078098
17. FTO modulates circadian rhythms and inhibits the CLOCK-BMAL1-induced transcription. PMID: 26188089
18. FTO expression and N6-methyladenosine levels are inversely correlated during adipogenesis. FTO depletion blocks differentiation and only catalytically active FTO restores adipogenesis. PMID: 25412662
19. FTO is present in both the nucleus and cytoplasm, with a mobile fraction that shuttles between both cellular compartments, possibly by interaction with XPO2. PMID: 25242086
20. FTO plays an important role in the development of metabolic disorders and is an interesting target for therapeutic agents. PMID: 25144618
21. data suggest that IRX3 is a functional long-range target of obesity-associated variants within FTO and represents a novel determinant of body mass and composition PMID: 24646999
22. FTO silencing did not modify PPARgamma2 mRNA levels. Partial reduction of FTO did not influence the first step of 3T3-L1 adipocyte differentiation. PMID: 23913730
23. Downregulation was seen only with essential amino-acid deficiency and not with non-essential amino acids. These data suggest that FTO might have a role in the sensing of essential amino-acid availability. PMID: 22614055
24. Data suggest that Fto-deficient white adipocytes exhibit some metabolic functions similar to brown adipocytes; expression of Ucp1 (uncoupling protein-1) is up-regulated and mitochondrial uncoupling is increased in Fto-deficient adipocytes. PMID: 23751871
25. Inactivation of the Fto gene impairs dopamine receptor types 2 & 3 control of neuronal activity & behavioral responses. FTO regulates the demethylation of specific mRNAs in vivo, and this activity relates to the control of DA transmission. PMID: 23817550
26. altered levels of FTO have multiple and diverse consequences on RNA modifications and the transcriptome PMID: 22872099
27. Our data suggest that Fto may have a critical role in the control of lean mass, independent of its effect on food intake. PMID: 23300482
28. These results provide important evidence that FTO-variant linked obesity may be associated with altered metabolic functions through activation of downstream metabolic mediators. PMID: 22675562
29. FTO plays a wide functional role in extracellular ligand-induced neuronal plasticity via NTRK2/BDNF. PMID: 22087873
30. The widespread expression of FTO in neurones also suggests that physiological studies of this protein should not be limited to the hypothalamus. PMID: 22140494
31. Fto, a proposed transcription co-factor, influences expression of the gene encoding a satiety mediator, oxytocin. PMID: 21514276
32. Results demonstrate that Fto plays an essential role in postnatal growth. PMID: 21103374
33. This study provides the first direct evidence that increased Fto expression causes obesity in mice. PMID: 21076408
34. The coactivator role of FTO in modulating the transcriptional regulation of adipogenesis by C/EBPs is consistent with the temporal progressive loss of adipose tissue in the Fto-deficient mice. PMID: 20858458
35. Hepatic Fto may participate in the feedback regulation of glucose metabolism via gluconeogenesis. PMID: 20816934
36. bioinformatics analysis shows FTO shares sequence motifs with Fe(II)- & 2-oxoglutarate-dependent oxygenases; recombinant Fto catalyzes the Fe(II)- & 2OG-dependent demethylation of 3-methylthymine in single-stranded DNA; Fto mRNA is most abundant in brain PMID: 17991826
37. Examined Fto/Ftm expression in obese mice exposed to overfeeding,underfeeding and cold. PMID: 18256137
38. Data show that the expression of FTO gene was reduced in adipocytes from db/db mice. PMID: 18647953
39. FTO can catalyze the demethylation of 3-meU in ssRNA with a slightly higher efficiency over that of 3-meT in ssDNA, suggesting that methylated RNAs are the preferred substrates for FTO. PMID: 18775698
40. first direct demonstration that Fto is functionally involved in energy homeostasis by the control of energy expenditure PMID: 19234441
41. A dominant missense mutation (I367F) in the mouse Fto gene results in a lean phenotype of reduced body weight and fat mass. PMID: 19680540
42. FTO mRNA is present mainly in sites related to hunger/satiation control; changes in hypothalamic FTO expression are associated with cues related to energy intake rather than feeding reward. Also, neurons involved in feeding termination express FTO. PMID: 19860904

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KEGG: mmu:26383

STRING: 10090.ENSMUSP00000068380

UniGene: Mm.4375