Recombinant Mouse Angiopoietin-related protein 2 (Angptl2)

1. ANGPTL2 up-regulation in skeletal myocytes accelerates muscle atrophy, and exercise-induced attenuation of ANGPTL2 expression in those tissues may partially explain how exercise training prevents sarcopenia. PMID: 29191837
2. Angptl2(-/-) in paraquat-treated mice attenuated acute lung injury progression by reducing the number of total cells, total leukocytes, neutrophils and macrophages in bronchoalveolar lavage fluid and reducing inflammatory response through the inactivation of nuclear factor kappa B pathway. PMID: 29852175
3. Kaempferol modulates the expression of ANGPTL2 to lessen the mastitis in mice. PMID: 29627690
4. These results support the importance of ANGPTL2 in the stem cell niche in regulating stemness and epithelial wound healing in the intestine. PMID: 28043948
5. we provide the first evidence for ANGPTL2 function in the acute ischemic brain. Infiltrated macrophage-derived ANGPTL2 enhanced inflammatory responses and was associated with severe brain tissue damage in the acute phase of ischemic stroke. PMID: 27861531
6. Angptl2 deficiency in lung epithelial cells and resident alveolar macrophages causes severe lung fibrosis seen following bleomycin treatment, suggesting that ANGPTL2 derived from these cell types plays a protective role against fibrosis in lung. PMID: 27542805
7. Angptl2 regulates not only adipose tissue metabolism but also bone metabolism PMID: 28285646
8. findings suggest that macrophage-derived ANGPTL2 promotes an innate immune response in those cells by enhancing proinflammatory activity and NO production required to fight infection. PMID: 27402837
9. Angptl2 might therefore represent a multistep regulator of CNV pathogenesis and serve as a new therapeutic target for age-related macular degeneration. PMID: 26839315
10. ANGPTL2 promotes adipose tissue macrophage and T lymphocyte accumulation and leads to insulin resistance. PMID: 26132105
11. It plays a role in tumor progression. PMID: 25090954
12. Angptl2 induces proinflammatory responses in peritoneal macrophages and monocytes. PMID: 26435501
13. In angptl2 knockdown mice, ACh-mediated endothelium-dependent vasodilation was greater than in WT mice. Lack of angptl2 expression limits the metabolic stress induced by a high-fat diet and maintains endothelial function in mice. PMID: 25128474
14. knockdown of angptl2 may be protective against ANG II-induced cerebral endothelial dysfunction; it favors the production of NO increasing endothelial cell resistance to stress. PMID: 25527773
15. Angptl2 expression was reduced in PHD3(-/-) bone-marrow-derived macrophages under stress conditions. PHD3 affects the production of Angptl2 and additionally influences the response toward this apoptosis-modulating factor. PMID: 24626957
16. Angptl2-induced inflammation increases susceptibility to microenvironmental changes, allowing increased oxidative stress and decreased Msh2 expression. PMID: 24258150
17. Endothelial cell-derived Angptl2 accelerates vascular inflammation by activating proinflammatory signaling in endothelial cells and increasing macrophage infiltration, leading to endothelial dysfunction and atherosclerosis progression. PMID: 24526691
18. periodic expression of ANGPTL2 is regulated by a molecular clock PMID: 23469106
19. Our findings demonstrated Angptl2 to be upregulated in corneal inflammation, and highlight that corneal hemangiogenesis and lymphangiogenesis may be driven by Angptk2 overexpression via macrophage infiltration and IL-1beta expression. PMID: 23702783
20. These findings may provide insight into the molecular mechanisms of the increased expression of Angptl2 and TGF-beta1 in obesity. PMID: 23261458
21. mediates endotoxin-induced retinal inflammation through the activation of NF-kappaB signaling pathway PMID: 22868908
22. Macrophage-derived Angptl2 contributes to abdominal aortic aneurysm development by inducing inflammation and degradation of extracellular matrix in the vessel wall. PMID: 22556334
23. demonstrate the ability of NOS2 to inhibit hyperoxia-induced Ang2 production and thereby decrease Ang2-induced tissue injury PMID: 22227562
24. tumor cell-derived ANGPTL2 drives metastasis and provided an initial proof of concept for blockade of its action as a strategy to antagonize the metastatic process. PMID: 22345152
25. keratinocyte-derived Angptl2 functions in dermatomyositis pathogenesis by inducing chronic inflammation in skin tissue. PMID: 22281496
26. Data suggest that angiopoietin-like protein 2 (Angptl2) contributes to increased carcinogenesis and metastasis and represents a novel target to antagonize these pathologies. PMID: 22042794
27. Tumor necrosis factor-alpha up-regulates Angptl2 mRNA expression via PI3K/Foxo1 pathway in adipocytes, which may be involved in obesity-induced inflammation and insulin resistance PMID: 21501655
28. This work pinpoints a specific lymphatic defect of Ang2(-/-) mice and further defines the sequential steps in lymphatic vessel remodeling. PMID: 18514180
29. Data suggest that interaction of ANG2, a proangiogenic factor, with its receptor Tie2 promotes neural progenitor cell differentiation into neuronal lineage cells. PMID: 19553662
30. Angiopoietin-like protein 2 (Angptl2) was secreted by adipose tissue and that its circulating level was closely related to adiposity, systemic insulin resistance, and inflammation in mice. PMID: 19723494

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KEGG: mmu:26360

STRING: 10090.ENSMUSP00000004208

UniGene: Mm.208919