Recombinant Mouse B-cell scaffold protein with ankyrin repeats (Bank1)

Code CSB-YP770470MO
MSDS
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Source Yeast
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Code CSB-EP770470MO
MSDS
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Source E.coli
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Code CSB-EP770470MO-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP770470MO
MSDS
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Source Baculovirus
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Code CSB-MP770470MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Bank1
Uniprot No.
Alternative Names
Bank1B-cell scaffold protein with ankyrin repeats; Protein AVIEF
Species
Mus musculus (Mouse)
Expression Region
1-783
Target Protein Sequence
MLPVASGTRG STQDLFQVGL APPGNAKDIL LLYEEDAEEW ALYLREIFMR VVEREAILLY PLHSFSSSHL EMLNFYAYKC KLLIISNSLL KDLTPKKCQF LEKILHSTGN VVTLLCGMES SDPFYQLLSI PRKRWEISTE QDPDGYISVI RQILDQGPED YLEVSIPTDS RAKYPEDTSG QKGTDVLASL RPSVPRVLVL PGEIPCEKPG EIFILLKDEL IGEILEVEFI STNKRLRARP ARWNKSVWHM KAADFPAGSV TVNIHCDGII KATTEIKYCS AAKATESPFR VSDPGKSLCQ KSIEELDNVL ASIFKREIPY YEFKHLQAET YPQKERTHTT ELPTLLHCAA KFGLKNLALH LLQCSGATRA ARMKATDGSD LLHIAERHGH EELKEVFEDF LSQNTGRNSK QENDYEEDVI SFSTYSPSMP SPASLHELRK THRRNTDRSE EPERSVEMKE EEAGAEARRS LSEGERESSE NQYDDLYVFI PGFDTEGNSE EPLPHCRPPL LPPRPGTAAS QLERPHFTSQ GKVLEDQMER SQNWNDLNAR PETREESSRE EKKEEAQEEE EEEENPYAFA ETEDNEYDLI LASKSVKKRT GNRSFIINRP PAPTPRPTHI PPKEETTPYI AQVFQQKAAR RQSDGDKFYS LPKKPDKTRM EGPTFPSTRD YLTTGQEELI LLQERVKNGK MSVDEALEKF KHWQMGKSGL EMIQQEKLRQ LRDNIIGKRP EDENAYDKLT IVHHPSGNTA HNENMLYNSP FNSKFPARIQ VEKEFGFCCK KDH
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

Customer Reviews and Q&A

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Target Background

Function
Involved in B-cell receptor (BCR)-induced Ca(2+) mobilization from intracellular stores. Promotes Lyn-mediated phosphorylation of IP3 receptors 1 and 2.
Gene References into Functions
  1. Following CpG stimulation of B-cells, BANK1 loss reduced p38 phosphorylation (but not ERK or JNK), IL-6 secretion, & MNK1/2 and eIF4E phosphorylation. It had no effect on IL-6 mRNA stability. BANK1 does not affect release of eIF4E by phospho-4E-BP1. PMID: 24227780
  2. BANK attenuates CD40-mediated Akt activation, thereby preventing hyperactive B cell responses. PMID: 16546095
Tissue Specificity
Specifically expressed in spleen. Highly expressed in immature B-cells and recirculating B-cells, and at low levels in pro-B and pre-B cells.
Database Links
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Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
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Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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