Recombinant Mouse Basic leucine zipper transcriptional factor ATF-like 2 (Batf2)

Code CSB-YP844435MO
MSDS
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Source Yeast
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Code CSB-EP844435MO
MSDS
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Source E.coli
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Code CSB-EP844435MO-B
MSDS
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP844435MO
MSDS
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Source Baculovirus
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Code CSB-MP844435MO
MSDS
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Source Mammalian cell
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Product Details

Purity
>85% (SDS-PAGE)
Target Names
Batf2
Uniprot No.
Alternative Names
Batf2Basic leucine zipper transcriptional factor ATF-like 2; B-ATF-2
Species
Mus musculus (Mouse)
Expression Region
1-277
Target Protein Sequence
MQLCGSSELL TETDLGESQK QLKKKQKNRV AAQRSRQKHT SKADALHQQH ESLEKQNHAL RKEIQALQTE LAGWGRTLHL HERLCRVDCD PCPVLLPSGC PIQAKQPSGQ PAPLGYNGCQ EQLGLFQTPG SSPRAQHLSP GPCSHESPGL LPSLLPSLAF DPLMVRTPLA QLSPSPVLSA SSPSGSSLLG SFSKLDPLIP SPQDQLAPPQ PLRQEQPTSG RLASSDSPAA LGPECSQNRE HLPALPGSST HWQKSSVAPS PQALMAFPLL SSAKVHF
Protein Length
full length protein
Tag Info
Tag type will be determined during the manufacturing process.
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form
Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization
Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution
We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
Troubleshooting and FAQs
Storage Condition
Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time
Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes
Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet
Please contact us to get it.

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Target Background

Function
AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types. Possibly acts by interfering with AP-1 binding to CCN1 promoter. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes.
Gene References into Functions
  1. Gain- and loss-of-function studies uncovered a role for Batf2 in myeloid differentiation in both murine and human systems. We thus demonstrate that chronic infection can deplete HSPCs and identify BATF2 as a mediator of infection-induced HSPC terminal differentiation PMID: 27926863
  2. controls Th17-mediated immunopathology by suppressing IL-23 production during Trypanosoma cruzi infection PMID: 28356392
  3. Batf2 has a central role in macrophage activation by regulating inflammatory responses during lipopolysaccharides stimulation and mycobacterial infection PMID: 26376615
  4. these results underline the role of Batf2/Irf1 in inducing inflammatory responses in M. tuberculosis infection. PMID: 25957166
Subcellular Location
Nucleus.
Protein Families
BZIP family
Database Links
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