Recombinant Mouse Basic leucine zipper transcriptional factor ATF-like 3 (Batf3)

1. These results underscore a specific role for Batf3-dependent dendritic cells in regulating priming and expansion of effector CD8(+) T cells necessary for host resistance against acute respiratory vaccinia virus infection. PMID: 29875235
2. Batf3 bound to the CNS1 region of the Foxp3 locus and reduced expression of the gene. Thus, Batf3 is a transcriptional suppressor of Treg differentiation. PMID: 29147008
3. The transcription factor Batf3 inhibits the differentiation of regulatory T cells in the periphery. We found that expression of Batf3 was selectively low in Treg cells but not in effector CD4 T (Teff) cells and that ectopic expression of Batf3 caused a marked reduction in the number of Foxp3+ Treg cells. Batf3 acts as a fate-decision factor with respect to Tconv versus Tregs by restraining Treg differentiation. PMID: 29147008
4. in contrast to adult mice, Batf3-dependent dendritic cells were absolutely required for generating rotavirus-specific CD8+ T-cell responses in neonates PMID: 27600308
5. Batf3(-/-) mice remained competent for skin graft rejection and delayed hypersensitivity, and retained a CD8(+) dendritic cell population. PMID: 27897162
6. Lack of Batf3/CD103(+) dendritic cells within the tumor microenvironment dominantly resists the effector phase of an anti-tumor T cell response, contributing to immune escape. PMID: 28486109
7. study reports that Batf3 is critical for accumulation of CD103(+) DCs in the kidney and tongue at steady state, for their expansion during systemic and oropharyngeal candidiasis, and for tissue-specific production of IL-12 in kidney but not tongue during systemic and oropharyngeal candidiasis, respectively PMID: 27191829
8. this study shows that Batf3 promotes priming of CD8+ T cells regardless of the location of Salmonella enterica antigen PMID: 26567886
9. Batf3 deficiency is not critical for the generation of CD8alpha dendritic cells. PMID: 25468565
10. Data indicte that interferon regulatory factor 8 (IRF8) expression becomes dependent on transcription factor Batf3. PMID: 26054719
11. IL-12 production by Batf3-dependent CD103+ dendritic cells is crucial for maintenance of local Th1 immunity against L. major infection. PMID: 25312824
12. The basic leucine zipper ATF-like 3 (BATF3)- dendritic cell lineage is enriched in the lungs of asthma-protected mice and strictly required for protection. PMID: 25074917
13. Irf8 expression in DC9 cells led to an increase in Batf3 transcript levels.When coexpressed with Irf8, Batf3 & Id2 had a synergistic effect on classical CD8alpha(+) DC development. PMID: 24227775
14. Batf3-dependent DCs in the renal lymph node presented antigen that had been concentrated in the kidney and used PD-L1 to induce apoptosis of cytotoxic T cells PMID: 23411785
15. A previously undescribed pathway by which CD8alpha+ Dendritic cells emerge independent of Id2, Nfil3, and Batf3, but dependent on Irf8. PMID: 23297132
16. Defective T effector priming and resistance to experimental autoimmune encephalitis (EAE) exhibited by Csf2rb(-/-) mice does not result from the absence of dermal CD11b(low/-)Langerin(+)CD103(+) dendritic cells. PMID: 22065991
17. study describes a transcription factor, Batf3, that controls development of CD8+ dendritic cells; dendritic cells from Batf3-/- mice were defective in cross-presentation, and Batf3-/- mice lacked virus-specific CD8+ T cell responses to West Nile virus PMID: 19008445

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KEGG: mmu:381319

STRING: 10090.ENSMUSP00000027943

UniGene: Mm.6922