Recombinant Mouse Bone morphogenetic protein 6(Bmp6)

Code CSB-YP002742MO
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Source Yeast
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Code CSB-EP002742MO
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Source E.coli
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Code CSB-EP002742MO-B
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Source E.coli
Conjugate Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
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Code CSB-BP002742MO
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Source Baculovirus
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Code CSB-MP002742MO
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Source Mammalian cell
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Product Details

Purity >85% (SDS-PAGE)
Target Names Bmp6
Uniprot No. P20722
Alternative Names Bmp6; Bmp-6; Vgr1Bone morphogenetic protein 6; BMP-6; VG-1-related protein; VGR-1
Species Mus musculus (Mouse)
Expression Region 372-510
Protein Length Full Length of Mature Protein
Tag Info The following tags are available.
N-terminal His-tagged
The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
Form Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
Buffer before Lyophilization Tris/PBS-based buffer, 6% Trehalose, pH 8.0
Reconstitution We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
and FAQs
Protein FAQs
Storage Condition Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
Shelf Life The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Lead Time Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
Notes Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet Please contact us to get it.

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Target Background

Growth factor of the TGF-beta superfamily that plays essential roles in many developmental processes including cartilage and bone formation. Plays also an important role in the regulation of iron metabolism by acting as a ligand for hemojuvelin/HJV. Initiates the canonical BMP signaling cascade by associating with type I receptor ACVR1 and type II receptor ACVR2B. In turn, ACVR1 propagates signal by phosphorylating SMAD1/5/8 that travel to the nucleus and act as activators and repressors of transcription of target. Can also signal through non-canonical pathway such as TAZ-Hippo signaling cascade to modulate VEGF signaling by regulating VEGFR2 expression.
Gene References into Functions
  1. These data suggest that, in Hjv(-/-) females, Bmp6 can provide a signal adequate to maintain hepcidin to a level sufficient to avoid extrahepatic iron loading. PMID: 29021231
  2. The data demonstrate that endothelial cells are the predominant source of BMP6 in the liver and support a model in which endothelial cells BMP6 has paracrine actions on hepatocyte hemojuvelin to regulate hepcidin transcription and maintain systemic iron homeostasis. PMID: 27864295
  3. In summary, our data suggest that in obstructive nephropathy atrophy increases and fibrosis decreases with age and that this relates to increased BMP signaling, most likely due to higher BMP6 and lower CTGF expression. PMID: 27558559
  4. In Bmp6-/- mice, iron activated endogenous compensatory mechanisms of other BMPs that were not sufficient for preventing hemochromatosis and bone loss. PMID: 25300398
  5. BMP6 expression levels may have potential as predictive markers for the progression of non-alcoholic liver disease. PMID: 25011936
  6. The expression of BMP6 in periodontal ligaments may contribute to interaction between the tooth and bone during the eruption and anchoring process. PMID: 25084210
  7. BMP-6 secreted by prostate cancer cells induces IL-6 expression in macrophages; IL-6, in turn, stimulates the neuroendocrine differentiation of prostate cancer cells. PMID: 21374653
  8. these data highlight a therapeutically innovative role for BMP6 by providing a means to enhance the amount of myogenic lineage derived brown fat. PMID: 24658703
  9. These results are consistent with novel mechanisms for regulating Bmp6 and Hamp1 expression. PMID: 24454764
  10. Prostate cancer-derived BMP-6 stimulates tumor-associated macrophages to produce IL-1a through a crosstalk between Smad1 and NF-kB1; IL-1a, in turn, promotes angiogenesis and prostate cancer growth. PMID: 24185914
  11. In addition to identifying BMP-6 expression in association with xerostomia and xerophthalmia in primary SS, results suggest that BMP-6-induced exocrine dysfunction in SS is independent of autoantibodies and immune activation associated with the disease. PMID: 23982860
  12. BMP-6 maintains epithelial polarity via intracellular signaling from basolaterally localized BMP receptors. PMID: 23675417
  13. During ovulation induction BMP-6 plays an important role in improvement of oocyte quality and ovarian response of the aged female, possibly by regulation of ovarian inhibitor of DNA-binding proteins (Ids) and VEGF expression. PMID: 23273273
  14. Data indicate that BMP-6 in renal cell carcinoma (RCC) cell lines is protumorigenic and involves IL-10-mediated M2 polarization of tumor-associated macrophages (TAM). PMID: 23633487
  15. the difference between bone morphogenetic protein-6 (BMP-6) and BMP-7 in enhancing gonadotropin-releasing hormone (GnRH) induced follicle stimulating hormone-beta transcription may be due to differential effects on GnRH-induced signaling PMID: 21846488
  16. Loss of Bmp6 regulates retinal iron homeostasis and is associated with age-related macular degeneration. PMID: 21703414
  17. results demonstrate that BMP-6-induced IL-1beta expression in macrophages is mediated via a cross-talk between the Smad and the non-Smad pathways through Smad1 and PU.1 PMID: 21571370
  18. Loss of endogenous BMP-6 would aggravate renal injury and fibrosis. PMID: 21356359
  19. BMP6 promotes normal fertility in female mice, at least in part, by enabling appropriate responses to luteinizing hormone and normal oocyte quality. PMID: 20702851
  20. Bmp6 decreased hepcidin levels; increased hepatic iron; and, importantly, corrected hematologic abnormalities in Tmprss6(-/-) mice PMID: 20940420
  21. interleukin-6 expression by bone morphogenetic protein-6 in macrophages requires both SMAD and p38 signaling pathways PMID: 20889504
  22. in a diabetic mouse model, smooth muscle progenitor cell levels are increased and SPC TGF-beta/BMP-6 expression is modulated PMID: 20858224
  23. the regulation of hepatic BMP6 expression by iron is independent of HJV, and expression of HJV in hepatocytes plays an essential role in hepcidin expression by potentiating the BMP6-mediated signaling PMID: 20363739
  24. Epithelial cells of the small intestine are the predominant cellular source of BMP6 upon iron sensing PMID: 19786029
  25. BMP-6 restores the bone inductive capacity, microarchitecture, and quality of the skeleton in osteoporotic rats PMID: 16798745
  26. These results indicate that the BMP6 are differentially expressed in adult spinal cord and are up-regulated during EAE. PMID: 17722066
  27. BMP-6 also plays a physiological role in maintaining growth plate function PMID: 17980691
  28. Our data indicate that Myo10 is required to guide endothelial migration toward BMP6 gradients via the regulation of filopodial function and amplification of BMP signals. PMID: 18158328
  29. Bmp6, Smad7, Id1, and Atoh8 transcripts are significantly modulated by the dietary iron content PMID: 18539898
  30. S1P induces osteoblast precursor recruitment and promotes mature cell survival. Wnt10b and BMP6 also were significantly increased in mature osteoclasts, whereas sclerostin levels decreased during differentiation. PMID: 19075223
  31. Mice deficient in Bmp6 develop classical hemochromatosis. PMID: 19252488
  32. Bone morphogenetic protein signaling is impaired in an HFE knockout mouse model of hemochromatosis. PMID: 19591830

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Subcellular Location Secreted.
Protein Families TGF-beta family
Tissue Specificity Expressed in the lung. Low levels seen in the kidney.
Database Links

KEGG: mmu:12161

STRING: 10090.ENSMUSP00000126999

UniGene: Mm.385759

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