Recombinant Mouse Cadherin-13 (Cdh13)

1. Findings show that Cdh13 is critical for inhibitory function of Golgi cells, and that GlyT2::Cre-mediated deletion of Cdh13 in non-executive centers of the brain, such as the cerebellum, may contribute to cognitive and social behavioral deficits linked to neurological disorders. PMID: 29446202
2. Studies findings identified a novel protective role for cadherin-13 in cortical neuron development. PMID: 28386779
3. using rat and murine aortic smooth muscle cells as experimental models, we surveyed the ability of T-cadherin to regulate autophagy in SMCs during serum-starvation stress. Overall our findings have identified T-cadherin as a novel positive regulator of autophagy and survival in smooth muscle cells PMID: 28392425
4. T-cadherin was essential for accumulation of adiponectin in the neointima and atherosclerotic plaque lesions, and the adiponectin-T-cadherin association protected against vascular injury. PMID: 28062540
5. T-cadherin deficiency causes endothelial dysfunction in Type II Diabetes Mellitus. PMID: 28103886
6. a unique key feature of the T-cad prodomain is its involvement in binding of the T-cad repeats 1 and 2 to adiponectin; adiponectin positively regulates T-cad abundance PMID: 28325833
7. CDH13 is a negative regulator of inhibitory synapses in the hippocampus, and provide insights into how CDH13 dysfunction may contribute to the excitatory/inhibitory imbalance observed in Attention Deficit Disorder with Hyperactivity. PMID: 26460479
8. These data show that both circulating and tissue-bound Adipo levels are dependent on Tcad and, in reverse, regulate tissue Tcad levels through a positive feedback loop. PMID: 25514086
9. These data highlight a previously unrecognized role for T-cadherin in limb revascularization and show that it is essential for mediating the vascular actions of adiponectin. PMID: 23824191
10. T-cad does not mediate the protective effects of adiponectin in allergic airways responses in mice PMID: 22815927
11. T-cadherin is a component of insulin granules, suggesting that it contributes to the regulation of insulin secretion independently of direct interactions with adiponectin. PMID: 21975561
12. T-cad can exert pleiotropic effects on squamous cell carcinoma progression; up- or down-regulation of T-cad can promote tumour expansion in vivo. PMID: 21766307
13. T-cadherin protects from stress-induced pathological cardiac remodeling by binding APN and activating its cardioprotective functions. PMID: 21041950
14. hyperexpression of T-cadherin in the B16F10 cells suppresses the proliferation of these cells in vitro and the growth of the tumor masses formed by melanoma cells on the chorioallantoic membrane and their neovascularization PMID: 20873143
15. Expression of T-cadherin in Basal keratinocytes of skin. PMID: 12060406
16. T-cadherin has a role in growth regulation involving p21(CIP1/WAF1) expression and G2 arrest PMID: 12509455
17. Because T-cadherin is a glycosylphosphatidylinositol-anchored extracellular protein, it may act as a coreceptor for an as-yet-unidentified signaling receptor through which adiponectin transmits metabolic signals. PMID: 15210937
18. T-cadherin is novel modulator of angiogenesis. Molecule can be exploited as target for modulation of therapeutic angiogenesis, as well as for prevention of pathological conditions associated with abnormal neovascularization. PMID: 16873731
19. T-cadherin suppresses angiogensis in vivo by inhibiting migration of endothelial cells. PMID: 17486418
20. the vascular T-cadherin-adiponectin association may contribute to the molecular cross-talk between tumor cells and the stromal compartment in breast cancer PMID: 18316604
21. both cellular and acellular presentation of T-cadherin can be used to modulate the hepatocyte phenotype in vitro for tissue engineering applications. PMID: 18635739

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KEGG: mmu:12554

STRING: 10090.ENSMUSP00000113527

UniGene: Mm.334841